GO.Biological.Process	GO:0032781	positive.regulation.of.ATPase.activity	1	8.203644e-201	1.059665e-196	1.059665e-196	1.705612e+1	AHSA2,DNAJC10,RYR2,TPM1	VertebrateAncestor	195.975
GO.Biological.Process	GO:0003065	positive.regulation.of.heart.rate.by.epinephrine	2	1.370302e-199	1.770019e-195	8.850095e-196	1.789923e+2	TPM1	VertebrateAncestor	194.752
GO.Biological.Process	GO:1900042	positive.regulation.of.interleukin-2.secretion	3	1.011842e-189	1.306996e-185	4.356654e-186	1.170318e+2	SPTBN1	VertebrateAncestor	184.884
GO.Biological.Process	GO:0030049	muscle.filament.sliding	4	2.524101e-181	3.260381e-177	8.150953e-178	2.514884e+1	ACTN2,MYH2,MYH4,MYH6,MYH7,MYH8,NEB,TPM1,TPM2,TTN	VertebrateAncestor	176.487
GO.Biological.Process	GO:0043462	regulation.of.ATPase.activity	5	9.383799e-181	1.212105e-176	2.424211e-177	1.283355e+1	AHSA2,DNAJC10,MYH6,RYR2,TPM1,TPM2	VertebrateAncestor	175.916
GO.Biological.Process	GO:0043001	Golgi.to.plasma.membrane.protein.transport	6	4.260592e-180	5.503407e-176	9.172344e-177	2.725489e+1	AMN,MACF1,SPTBN1	VertebrateAncestor	175.259
GO.Biological.Process	GO:0010256	endomembrane.system.organization	7	3.898599e-170	5.035820e-166	7.194029e-167	3.911508e+0	ACTN2,AMN,ARL6IP1,BAG5,BAIAP2,CHMP6,DCHS1,DNAJC13,FAT4,FLNA,LAMA5,MACF1,MYH2,MYOF,RILP,SCRIB,SEC16A,SMURF1,SPTBN1,SPTBN5,SYNE1,WASHC4	VertebrateAncestor	165.298
GO.Biological.Process	GO:0032970	regulation.of.actin.filament-based.process	8	1.261366e-169	1.629306e-165	2.036633e-166	4.415016e+0	ACTN2,ARFIP2,BAIAP2,CELSR1,FLNA,ILK,LRP1,MYH9,NCKAP1,NEB,RYR2,SPTBN1,SPTBN5,TPM1	VertebrateAncestor	164.788
GO.Biological.Process	GO:1904902	ESCRT.III.complex.assembly	9	5.163236e-158	6.669352e-154	7.410391e-155	1.652077e+2	CHMP6	VertebrateAncestor	153.176
GO.Biological.Process	GO:1904753	negative.regulation.of.vascular.associated.smooth.muscle.cell.migration	10	1.316751e-153	1.700847e-149	1.700847e-150	6.654922e+1	TPM1	VertebrateAncestor	148.769
GO.Biological.Process	GO:0090002	establishment.of.protein.localization.to.plasma.membrane	11	9.309331e-148	1.202486e-143	1.093169e-144	1.620519e+1	AMN,MACF1,SCRIB,SPTBN1	VertebrateAncestor	142.92
GO.Biological.Process	GO:1900040	regulation.of.interleukin-2.secretion	12	7.423807e-145	9.589332e-141	7.991110e-142	4.670933e+1	SPTBN1	VertebrateAncestor	140.018
GO.Biological.Process	GO:0051693	actin.filament.capping	13	1.091225e-144	1.409535e-140	1.084258e-141	2.377639e+1	SPTBN1,SPTBN5	VertebrateAncestor	139.851
GO.Biological.Process	GO:0030048	actin.filament-based.movement	14	2.624652e-144	3.390263e-140	2.421616e-141	7.306224e+0	ACTN2,MYH2,MYH4,MYH6,MYH7,MYH8,MYH9,MYO7A,NEB,RYR2,SCN1A,TPM1,TPM2,TTN	VertebrateAncestor	139.47
GO.Biological.Process	GO:0032956	regulation.of.actin.cytoskeleton.organization	15	5.183063e-143	6.694962e-139	4.463308e-140	4.439742e+0	ACTN2,ARFIP2,BAIAP2,CELSR1,ILK,LRP1,NCKAP1,NEB,SPTBN1,SPTBN5,TPM1	VertebrateAncestor	138.174
GO.Biological.Process	GO:0007018	microtubule-based.movement	16	5.569002e-140	7.193480e-136	4.495925e-137	5.142180e+0	DNAH10,DNAH12,DNAH17,DNAH5,DNAH6,DNAH7,DNAH9,DNHD1,DST,DYNC1H1,KIF1B,SPG7,TTC21B	VertebrateAncestor	135.143
GO.Biological.Process	GO:1904706	negative.regulation.of.vascular.smooth.muscle.cell.proliferation	17	6.079714e-139	7.853167e-135	4.619510e-136	4.841962e+1	TPM1	VertebrateAncestor	134.105
GO.Biological.Process	GO:0007184	SMAD.protein.import.into.nucleus	18	3.788739e-136	4.893914e-132	2.718841e-133	3.901805e+1	SPTBN1	VertebrateAncestor	131.31
GO.Biological.Process	GO:0030835	negative.regulation.of.actin.filament.depolymerization	19	1.226511e-134	1.584284e-130	8.338338e-132	2.016840e+1	SPTBN1,SPTBN5	VertebrateAncestor	129.8
GO.Biological.Process	GO:0007010	cytoskeleton.organization	20	3.796814e-132	4.904345e-128	2.452172e-129	2.623708e+0	ACTN2,ARFIP2,BAIAP2,CDC42BPB,CKAP5,DNAH5,DNAH7,DNHD1,DST,DYNC1H1,EPPK1,FAM83H,FAT1,FLNA,LAMA5,MARK3,MYH6,MYH9,MYOM2,NCKIPSD,PSRC1,SETD2,SPTBN1,SPTBN5,SYNE1,TLN2,TPM1,TPM2,TTN,WEE1	VertebrateAncestor	127.309
GO.Biological.Process	GO:0006893	Golgi.to.plasma.membrane.transport	21	9.372755e-132	1.210679e-127	5.765137e-129	1.385057e+1	AMN,MACF1,SPTBN1	VertebrateAncestor	126.917
GO.Biological.Process	GO:0018076	N-terminal.peptidyl-lysine.acetylation	22	8.580111e-129	1.108293e-124	5.037695e-126	9.321916e+1	CREBBP	VertebrateAncestor	123.955
GO.Biological.Process	GO:0007009	plasma.membrane.organization	23	2.485509e-128	3.210532e-124	1.395883e-125	4.808645e+0	ACTN2,AMN,BAIAP2,DCHS1,FAT4,FLNA,LAMA5,MACF1,MYH2,MYOF,SCRIB,SMURF1,SPTBN1	VertebrateAncestor	123.493
GO.Biological.Process	GO:0030834	regulation.of.actin.filament.depolymerization	24	2.116456e-126	2.733826e-122	1.139094e-123	1.368907e+1	ACTN2,SPTBN1,SPTBN5	VertebrateAncestor	121.563
GO.Biological.Process	GO:0045214	sarcomere.organization	25	1.079137e-124	1.393921e-120	5.575685e-122	1.620534e+1	ACTN2,MYH6,MYOM2,TPM1,TTN	VertebrateAncestor	119.856
GO.Biological.Process	GO:0006936	muscle.contraction	26	2.704667e-121	3.493618e-117	1.343699e-118	4.293647e+0	ACTN2,ATP1A3,HMCN2,MYH1,MYH2,MYH4,MYH6,MYH7,MYH8,MYOF,MYOM2,NEB,RYR1,RYR2,SCN1A,TPM1,TPM2,TTN	VertebrateAncestor	116.457
GO.Biological.Process	GO:0070925	organelle.assembly	27	7.276687e-121	9.399297e-117	3.481221e-118	3.241451e+0	ACTN2,BBS7,CELSR3,CENPS,CHMP6,CKAP5,DNAH5,DNAH6,DNAH7,DNHD1,DYNC1H1,FLNA,GALNT11,HSP90AA1,LAMA5,MDN1,MYH6,MYO7A,MYOM2,NOTCH1,RILP,SMURF1,TPM1,TTC21B,TTN	VertebrateAncestor	116.027
GO.Biological.Process	GO:0006766	vitamin.metabolic.process	28	3.353310e-119	4.331471e-115	1.546954e-116	7.368489e+0	ABCC1,ACACB,ALDH1L2,AMN,CYP26A1,CYP26C1,FASN,LRP2,MTR,SHMT2,TKTL1	VertebrateAncestor	114.363
GO.Biological.Process	GO:0032507	maintenance.of.protein.location.in.cell	29	1.198377e-118	1.547944e-114	5.337736e-116	1.034479e+1	FLNA,GRIK5,SYNE1,TLN2	VertebrateAncestor	113.81
GO.Biological.Process	GO:0070252	actin-mediated.cell.contraction	30	1.115928e-117	1.441444e-113	4.804814e-115	7.200117e+0	ACTN2,MYH2,MYH4,MYH6,MYH7,MYH8,NEB,RYR2,SCN1A,TPM1,TPM2,TTN	VertebrateAncestor	112.841
GO.Biological.Process	GO:0003062	regulation.of.heart.rate.by.chemical.signal	31	3.555467e-117	4.592597e-113	1.481483e-114	3.007701e+1	TPM1	VertebrateAncestor	112.338
GO.Biological.Process	GO:0007182	common-partner.SMAD.protein.phosphorylation	32	1.238693e-116	1.600020e-112	5.000062e-114	2.598636e+1	SPTBN1	VertebrateAncestor	111.796
GO.Biological.Process	GO:0001996	positive.regulation.of.heart.rate.by.epinephrine-norepinephrine	33	1.227629e-115	1.585728e-111	4.805238e-113	2.907472e+1	TPM1	VertebrateAncestor	110.8
GO.Biological.Process	GO:1990778	protein.localization.to.cell.periphery	34	4.312106e-113	5.569947e-109	1.638220e-110	5.135050e+0	ACTN2,AMN,DCHS1,FLNA,KIF1B,LAMA5,MACF1,SCRIB,SMURF1,SPTBN1	VertebrateAncestor	108.254
GO.Biological.Process	GO:0055010	ventricular.cardiac.muscle.tissue.morphogenesis	35	4.334862e-113	5.599341e-109	1.599812e-110	8.319186e+0	LRP2,MYH6,MYH7,NOTCH1,RYR2,TPM1,UBE4B	VertebrateAncestor	108.252
GO.Biological.Process	GO:0010460	positive.regulation.of.heart.rate	36	5.097678e-112	6.584671e-108	1.829075e-109	1.228558e+1	RYR2,TPM1	VertebrateAncestor	107.181
GO.Biological.Process	GO:0031529	ruffle.organization	37	3.947648e-111	5.099177e-107	1.378156e-108	2.362736e+1	ARFIP2,TPM1	VertebrateAncestor	106.292
GO.Biological.Process	GO:0070367	negative.regulation.of.hepatocyte.differentiation	38	1.789439e-110	2.311418e-106	6.082680e-108	1.719755e+2	FRZB	VertebrateAncestor	105.636
GO.Biological.Process	GO:0034653	retinoic.acid.catabolic.process	39	2.170506e-109	2.803643e-105	7.188827e-107	3.949138e+1	CYP26A1,CYP26C1	VertebrateAncestor	104.552
GO.Biological.Process	GO:1904752	regulation.of.vascular.associated.smooth.muscle.cell.migration	40	5.085651e-108	6.569135e-104	1.642284e-105	2.456739e+1	TPM1	VertebrateAncestor	103.182
GO.Biological.Process	GO:0006892	post-Golgi.vesicle-mediated.transport	41	5.132655e-107	6.629850e-103	1.617037e-104	7.910495e+0	AMN,MACF1,MON2,SPTBN1	VertebrateAncestor	102.178
GO.Biological.Process	GO:0045185	maintenance.of.protein.location	42	1.700447e-106	2.196467e-102	5.229684e-104	8.737787e+0	FLNA,GRIK5,SYNE1,TLN2	VertebrateAncestor	101.658
GO.Biological.Process	GO:0051493	regulation.of.cytoskeleton.organization	43	9.391814e-106	1.213141e-101	2.821257e-103	3.229428e+0	ACTN2,ARFIP2,BAIAP2,CELSR1,DYNC1H1,ILK,LRP1,NCKAP1,NEB,PSRC1,SPTBN1,SPTBN5,TPM1,TRIM54,XPO1	VertebrateAncestor	100.916
GO.Biological.Process	GO:0098876	vesicle-mediated.transport.to.the.plasma.membrane	44	3.194101e-105	4.125820e-101	9.376864e-103	8.943545e+0	AMN,MACF1,SCRIB,SPTBN1	VertebrateAncestor	100.384
GO.Biological.Process	GO:0070366	regulation.of.hepatocyte.differentiation	45	5.418218e-105	6.998712e-101	1.555269e-102	1.391681e+2	FRZB	VertebrateAncestor	100.155
GO.Biological.Process	GO:0016115	terpenoid.catabolic.process	46	6.589172e-105	8.511233e-101	1.850268e-102	3.515128e+1	CYP26A1,CYP26C1	VertebrateAncestor	100.07
GO.Biological.Process	GO:0030837	negative.regulation.of.actin.filament.polymerization	47	5.417745e-104	6.998101e-100	1.488958e-101	1.209319e+1	SPTBN1,SPTBN5	VertebrateAncestor	99.155
GO.Biological.Process	GO:0030832	regulation.of.actin.filament.length	48	3.841626e-103	4.962228e-99	1.033798e-100	5.529004e+0	ACTN2,ARFIP2,BAIAP2,NCKAP1,NEB,SPTBN1,SPTBN5	VertebrateAncestor	98.3043
GO.Biological.Process	GO:1900034	regulation.of.cellular.response.to.heat	49	5.316815e-103	6.867730e-99	1.401578e-100	9.117734e+0	BAG5,CREBBP,HSP90AA1,RPTOR	VertebrateAncestor	98.1632
GO.Biological.Process	GO:0042363	fat-soluble.vitamin.catabolic.process	50	6.397011e-103	8.263019e-99	1.652604e-100	3.337903e+1	CYP26A1,CYP26C1	VertebrateAncestor	98.0829
GO.Biological.Process	GO:0003229	ventricular.cardiac.muscle.tissue.development	51	2.526795e-102	3.263861e-98	6.399728e-100	7.235001e+0	LRP2,MYH6,MYH7,NOTCH1,RYR2,TPM1,UBE4B	VertebrateAncestor	97.4863
GO.Biological.Process	GO:1902903	regulation.of.supramolecular.fiber.organization	52	3.511762e-102	4.536143e-98	8.723352e-100	3.871332e+0	ACTN2,ARFIP2,BAIAP2,NCKAP1,PSRC1,SPTBN1,SPTBN5,TPM1,TRIM54	VertebrateAncestor	97.3433
GO.Biological.Process	GO:0007017	microtubule-based.process	53	1.904650e-101	2.460236e-97	4.641955e-99	3.050137e+0	CKAP5,DNAH10,DNAH12,DNAH17,DNAH5,DNAH6,DNAH7,DNAH9,DNHD1,DST,DYNC1H1,FLNA,KIF1B,MARK3,MYH9,PSRC1,SETD2,SPG7,TRIM54,TTC21B,WEE1	VertebrateAncestor	96.609
GO.Biological.Process	GO:0031032	actomyosin.structure.organization	54	2.689225e-101	3.473672e-97	6.432726e-99	7.045497e+0	ACTN2,CDC42BPB,MYH6,MYH9,MYOM2,TPM1,TTN	VertebrateAncestor	96.4592
GO.Biological.Process	GO:0045823	positive.regulation.of.heart.contraction	55	5.767992e-101	7.450515e-97	1.354639e-98	9.787818e+0	RYR2,TPM1,UCN	VertebrateAncestor	96.1278
GO.Biological.Process	GO:1904647	response.to.rotenone	56	5.998029e-101	7.747654e-97	1.383510e-98	1.456990e+2	KIF1B	VertebrateAncestor	96.1108
GO.Biological.Process	GO:0008300	isoprenoid.catabolic.process	57	3.600707e-100	4.651033e-96	8.159707e-98	3.106841e+1	CYP26A1,CYP26C1	VertebrateAncestor	95.3325
GO.Biological.Process	GO:0007016	cytoskeletal.anchoring.at.plasma.membrane	58	1.695809e-98	2.190476e-94	3.776684e-96	2.540256e+1	TLN2	VertebrateAncestor	93.6595
GO.Biological.Process	GO:0051651	maintenance.of.location.in.cell	59	2.818483e-98	3.640634e-94	6.170567e-96	7.779577e+0	FLNA,GRIK5,SYNE1,TLN2	VertebrateAncestor	93.4388
GO.Biological.Process	GO:0003321	positive.regulation.of.blood.pressure.by.epinephrine-norepinephrine	60	8.355308e-97	1.079255e-92	1.798759e-94	1.912907e+1	TPM1	VertebrateAncestor	91.9669
GO.Biological.Process	GO:0009111	vitamin.catabolic.process	61	4.302943e-96	5.558111e-92	9.111658e-94	2.792543e+1	CYP26A1,CYP26C1	VertebrateAncestor	91.2551
GO.Biological.Process	GO:0071233	cellular.response.to.leucine	62	6.731997e-95	8.695721e-91	1.402536e-92	4.375904e+1	RPTOR	VertebrateAncestor	90.0607
GO.Biological.Process	GO:0055008	cardiac.muscle.tissue.morphogenesis	63	8.602615e-95	1.111200e-90	1.763809e-92	6.169116e+0	LRP2,MYH6,MYH7,NOTCH1,RYR2,TPM1,TTN,UBE4B	VertebrateAncestor	89.9542
GO.Biological.Process	GO:1901880	negative.regulation.of.protein.depolymerization	64	4.525389e-94	5.845445e-90	9.133508e-92	9.384042e+0	SPTBN1,SPTBN5,TRIM54	VertebrateAncestor	89.2332
GO.Biological.Process	GO:0061061	muscle.structure.development	65	9.466361e-94	1.222770e-89	1.881184e-91	2.733938e+0	ACTN2,FLNC,LAMA5,LRP2,MYH6,MYH7,MYH9,MYOF,MYOM2,NEB,NOTCH1,RYR1,RYR2,SGCG,SYNE1,TPM1,TRIM54,TTN,UBE4B,ZFHX3	VertebrateAncestor	88.9127
GO.Biological.Process	GO:0048387	negative.regulation.of.retinoic.acid.receptor.signaling.pathway	66	3.733703e-93	4.822824e-89	7.307309e-91	2.078412e+1	CNOT1,CYP26A1,CYP26C1	VertebrateAncestor	88.3167
GO.Biological.Process	GO:0001993	regulation.of.systemic.arterial.blood.pressure.by.norepinephrine-epinephrine	67	7.583617e-93	9.795758e-89	1.462053e-90	1.749926e+1	TPM1	VertebrateAncestor	88.009
GO.Biological.Process	GO:0043242	negative.regulation.of.protein.complex.disassembly	68	1.678072e-92	2.167566e-88	3.187596e-90	9.143445e+0	SPTBN1,SPTBN5,TRIM54	VertebrateAncestor	87.664
GO.Biological.Process	GO:0008064	regulation.of.actin.polymerization.or.depolymerization	69	7.496365e-92	9.683055e-88	1.403341e-89	5.231167e+0	ACTN2,ARFIP2,BAIAP2,NCKAP1,SPTBN1,SPTBN5	VertebrateAncestor	87.014
GO.Biological.Process	GO:0003012	muscle.system.process	70	1.045395e-91	1.350337e-87	1.929052e-89	3.386662e+0	ACTN2,ATP1A3,HMCN2,MYH1,MYH2,MYH4,MYH6,MYH7,MYH8,MYOF,MYOM2,NEB,RYR1,RYR2,SCN1A,TPM1,TPM2,TTN	VertebrateAncestor	86.8696
GO.Biological.Process	GO:1901879	regulation.of.protein.depolymerization	71	1.454660e-91	1.878984e-87	2.646457e-89	7.558907e+0	ACTN2,SPTBN1,SPTBN5,TRIM54	VertebrateAncestor	86.7261
GO.Biological.Process	GO:0014912	negative.regulation.of.smooth.muscle.cell.migration	72	1.504118e-91	1.942869e-87	2.698429e-89	1.230527e+1	ILK,LRP1,TPM1	VertebrateAncestor	86.7116
GO.Biological.Process	GO:0030239	myofibril.assembly	73	2.169434e-91	2.802258e-87	3.838709e-89	9.341234e+0	ACTN2,MYH6,MYOM2,TPM1,TTN	VertebrateAncestor	86.5525
GO.Biological.Process	GO:0032535	regulation.of.cellular.component.size	74	3.022391e-91	3.904022e-87	5.275706e-89	3.373634e+0	ACTN2,ARFIP2,BAIAP2,ILK,MACF1,NCKAP1,NEB,RILP,RPTOR,SPTBN1,SPTBN5,UCN	VertebrateAncestor	86.4085
GO.Biological.Process	GO:0071313	cellular.response.to.caffeine	75	4.411544e-91	5.698391e-87	7.597855e-89	1.747218e+1	RYR1,RYR2,RYR3	VertebrateAncestor	86.2442
GO.Biological.Process	GO:0090292	nuclear.matrix.anchoring.at.nuclear.membrane	76	4.613831e-91	5.959686e-87	7.841691e-89	5.147603e+1	SYNE1	VertebrateAncestor	86.2248
GO.Biological.Process	GO:0042573	retinoic.acid.metabolic.process	77	6.258586e-91	8.084216e-87	1.049898e-88	1.741129e+1	CYP26A1,CYP26C1,DHRS9	VertebrateAncestor	86.0924
GO.Biological.Process	GO:0071415	cellular.response.to.purine-containing.compound	78	2.913162e-90	3.762931e-86	4.824271e-88	1.714588e+1	RYR1,RYR2,RYR3	VertebrateAncestor	85.4245
GO.Biological.Process	GO:0032272	negative.regulation.of.protein.polymerization	79	6.208495e-90	8.019513e-86	1.015128e-87	9.496449e+0	SPTBN1,SPTBN5	VertebrateAncestor	85.0959
GO.Biological.Process	GO:0016255	attachment.of.GPI.anchor.to.protein	80	6.609472e-90	8.537455e-86	1.067182e-87	5.172849e+1	PGAP1	VertebrateAncestor	85.0687
GO.Biological.Process	GO:0000920	cell.separation.after.cytokinesis	81	1.599875e-89	2.066559e-85	2.551307e-87	2.614093e+1	CHMP6	VertebrateAncestor	84.6848
GO.Biological.Process	GO:0038202	TORC1.signaling	82	2.808933e-89	3.628299e-85	4.424755e-87	3.675291e+1	RPTOR	VertebrateAncestor	84.4403
GO.Biological.Process	GO:1904705	regulation.of.vascular.smooth.muscle.cell.proliferation	83	5.330611e-89	6.885550e-85	8.295844e-87	1.604122e+1	TPM1	VertebrateAncestor	84.1621
GO.Biological.Process	GO:0030833	regulation.of.actin.filament.polymerization	84	1.067246e-88	1.378562e-84	1.641145e-86	5.552228e+0	ARFIP2,BAIAP2,NCKAP1,SPTBN1,SPTBN5	VertebrateAncestor	83.8606
GO.Biological.Process	GO:0098930	axonal.transport	85	1.931522e-87	2.494947e-83	2.935232e-85	1.309948e+1	DST,KIF1B,SPG7	VertebrateAncestor	82.6029
GO.Biological.Process	GO:0006474	N-terminal.protein.amino.acid.acetylation	86	3.184231e-87	4.113071e-83	4.782641e-85	2.833257e+1	CREBBP	VertebrateAncestor	82.3858
GO.Biological.Process	GO:0060048	cardiac.muscle.contraction	87	1.899030e-86	2.452977e-82	2.819514e-84	6.182922e+0	ATP1A3,MYH6,MYH7,RYR2,SCN1A,TPM1,TTN	VertebrateAncestor	81.6103
GO.Biological.Process	GO:0001731	formation.of.translation.preinitiation.complex	88	4.904364e-86	6.334967e-82	7.198826e-84	6.673054e+1	EIF5	VertebrateAncestor	81.1983
GO.Biological.Process	GO:0039702	viral.budding.via.host.ESCRT.complex	89	3.933893e-85	5.081410e-81	5.709449e-83	2.316314e+1	CHMP6	VertebrateAncestor	80.294
GO.Biological.Process	GO:0060415	muscle.tissue.morphogenesis	90	6.227848e-84	8.044511e-80	8.938346e-82	5.357782e+0	LRP2,MYH6,MYH7,NOTCH1,RYR2,TPM1,TTN,UBE4B	VertebrateAncestor	79.0945
GO.Biological.Process	GO:0043244	regulation.of.protein.complex.disassembly	91	7.462316e-84	9.639074e-80	1.059239e-81	6.724406e+0	ACTN2,SPTBN1,SPTBN5,TRIM54	VertebrateAncestor	79.016
GO.Biological.Process	GO:0070903	mitochondrial.tRNA.thio-modification	92	2.055293e-83	2.654822e-79	2.885676e-81	1.734254e+2	TRMU	VertebrateAncestor	78.576
GO.Biological.Process	GO:0007175	negative.regulation.of.epidermal.growth.factor-activated.receptor.activity	93	2.364856e-83	3.054684e-79	3.284607e-81	2.205159e+1	CHMP6	VertebrateAncestor	78.515
GO.Biological.Process	GO:0006655	phosphatidylglycerol.biosynthetic.process	94	1.070247e-82	1.382438e-78	1.470679e-80	4.203999e+1	CDS1,PGS1	VertebrateAncestor	77.8594
GO.Biological.Process	GO:0016055	Wnt.signaling.pathway	95	1.084458e-82	1.400794e-78	1.474520e-80	3.089391e+0	CELSR1,CELSR2,CELSR3,FRZB,LRP4,MACF1,OTULIN,PSME4,RYR2,SMURF1,TRABD2A,USP34	VertebrateAncestor	77.8536
GO.Biological.Process	GO:0090251	protein.localization.involved.in.establishment.of.planar.polarity	96	1.503494e-82	1.942063e-78	2.022982e-80	1.515133e+2	CELSR1	VertebrateAncestor	77.7117
GO.Biological.Process	GO:0046755	viral.budding	97	5.053202e-82	6.527221e-78	6.729094e-80	2.125417e+1	CHMP6	VertebrateAncestor	77.1853
GO.Biological.Process	GO:0006941	striated.muscle.contraction	98	4.489126e-81	5.798604e-77	5.916943e-79	5.294773e+0	ATP1A3,MYH6,MYH7,MYH8,MYOM2,RYR2,SCN1A,TPM1,TTN	VertebrateAncestor	76.2367
GO.Biological.Process	GO:0015798	myo-inositol.transport	99	1.061973e-80	1.371751e-76	1.385607e-78	3.761040e+1	PGAP1	VertebrateAncestor	75.8627
GO.Biological.Process	GO:0048385	regulation.of.retinoic.acid.receptor.signaling.pathway	100	2.618636e-80	3.382492e-76	3.382492e-78	1.520213e+1	CNOT1,CYP26A1,CYP26C1	VertebrateAncestor	75.4708
GO.Biological.Process	GO:0031000	response.to.caffeine	101	3.082182e-80	3.981254e-76	3.941836e-78	1.359040e+1	RYR1,RYR2,RYR3	VertebrateAncestor	75.4
GO.Biological.Process	GO:0048644	muscle.organ.morphogenesis	102	3.355203e-80	4.333916e-76	4.248937e-78	5.099450e+0	LRP2,MYH6,MYH7,NOTCH1,RYR2,TPM1,TTN,UBE4B	VertebrateAncestor	75.3631
GO.Biological.Process	GO:0051601	exocyst.localization	103	4.314005e-79	5.572400e-75	5.410097e-77	2.854905e+1	EXOC3L4,TNFAIP2	VertebrateAncestor	74.254
GO.Biological.Process	GO:0008088	axo-dendritic.transport	104	6.475923e-79	8.364950e-75	8.043221e-77	1.093236e+1	DST,KIF1B,SPG7	VertebrateAncestor	74.0775
GO.Biological.Process	GO:0090150	establishment.of.protein.localization.to.membrane	105	5.319748e-77	6.871518e-73	6.544303e-75	4.815329e+0	AMN,ARL6IP1,ENSG00000260342,HSP90AA1,MACF1,RFTN2,RPL13,RPS15A,SCRIB,SPTBN1	VertebrateAncestor	72.1629
GO.Biological.Process	GO:0034754	cellular.hormone.metabolic.process	106	1.480913e-76	1.912895e-72	1.804618e-74	6.006841e+0	CYP26A1,CYP26C1,DHRS9,ESR1	VertebrateAncestor	71.7183
GO.Biological.Process	GO:0072659	protein.localization.to.plasma.membrane	107	2.518638e-76	3.253325e-72	3.040490e-74	4.301088e+0	ACTN2,AMN,DCHS1,FLNA,LAMA5,MACF1,SCRIB,SMURF1,SPTBN1	VertebrateAncestor	71.4877
GO.Biological.Process	GO:0060068	vagina.development	108	4.686220e-76	6.053190e-72	5.604806e-74	1.939161e+1	ESR1,LRP2	VertebrateAncestor	71.218
GO.Biological.Process	GO:0060047	heart.contraction	109	1.234789e-75	1.594977e-71	1.463282e-73	5.209500e+0	ATP1A3,MYH6,MYH7,RYR2,SCN1A,SGCG,TPM1,TTN	VertebrateAncestor	70.7972
GO.Biological.Process	GO:0014808	release.of.sequestered.calcium.ion.into.cytosol.by.sarcoplasmic.reticulum	110	2.347923e-75	3.032812e-71	2.757102e-73	3.121986e+1	RYR1,RYR2	VertebrateAncestor	70.5182
GO.Biological.Process	GO:0042692	muscle.cell.differentiation	111	4.021912e-75	5.195104e-71	4.680274e-73	3.141071e+0	ACTN2,FLNC,MYH6,MYH9,MYOF,MYOM2,NOTCH1,RYR1,SGCG,SYNE1,TPM1,TRIM54,TTN	VertebrateAncestor	70.2844
GO.Biological.Process	GO:0030029	actin.filament-based.process	112	4.728939e-75	6.108371e-71	5.453902e-73	2.631793e+0	ACTN2,ARFIP2,BAIAP2,CDC42BPB,FAT1,FLNA,MYH2,MYH4,MYH6,MYH7,MYH8,MYH9,MYO7A,MYOM2,NEB,RYR2,SCN1A,SPTBN5,TPM1,TPM2,TTN	VertebrateAncestor	70.2141
GO.Biological.Process	GO:0001778	plasma.membrane.repair	113	1.058029e-74	1.366656e-70	1.209430e-72	3.433230e+1	MYH2,MYOF	VertebrateAncestor	69.8643
GO.Biological.Process	GO:0032271	regulation.of.protein.polymerization	114	1.463877e-74	1.890890e-70	1.658675e-72	4.535335e+0	ARFIP2,BAIAP2,NCKAP1,PSRC1,SPTBN1,SPTBN5	VertebrateAncestor	69.7233
GO.Biological.Process	GO:0006775	fat-soluble.vitamin.metabolic.process	115	1.525501e-74	1.970490e-70	1.713469e-72	1.188830e+1	CYP26A1,CYP26C1,LRP2	VertebrateAncestor	69.7054
GO.Biological.Process	GO:0036258	multivesicular.body.assembly	116	4.259833e-74	5.502426e-70	4.743471e-72	1.704038e+1	CHMP6	VertebrateAncestor	69.2594
GO.Biological.Process	GO:0015791	polyol.transport	117	4.845629e-74	6.259099e-70	5.349657e-72	2.677938e+1	PGAP1,SLC26A6	VertebrateAncestor	69.2035
GO.Biological.Process	GO:0002143	tRNA.wobble.position.uridine.thiolation	118	6.789355e-74	8.769810e-70	7.432042e-72	1.061820e+2	TRMU	VertebrateAncestor	69.057
GO.Biological.Process	GO:0060488	orthogonal.dichotomous.subdivision.of.terminal.units.involved.in.lung.branching.morphogenesis	119	7.882614e-74	1.018197e-69	8.556279e-72	9.758132e+1	CELSR1	VertebrateAncestor	68.9922
GO.Biological.Process	GO:0060489	planar.dichotomous.subdivision.of.terminal.units.involved.in.lung.branching.morphogenesis	119	7.882614e-74	1.018197e-69	8.556279e-72	9.758132e+1	CELSR1	VertebrateAncestor	68.9922
GO.Biological.Process	GO:0060490	lateral.sprouting.involved.in.lung.morphogenesis	119	7.882614e-74	1.018197e-69	8.556279e-72	9.758132e+1	CELSR1	VertebrateAncestor	68.9922
GO.Biological.Process	GO:1990108	protein.linear.deubiquitination	122	1.340511e-73	1.731538e-69	1.419293e-71	4.523400e+1	OTULIN	VertebrateAncestor	68.7616
GO.Biological.Process	GO:0036257	multivesicular.body.organization	123	2.944869e-73	3.803887e-69	3.092591e-71	1.664342e+1	CHMP6	VertebrateAncestor	68.4198
GO.Biological.Process	GO:1903524	positive.regulation.of.blood.circulation	124	3.637585e-73	4.698669e-69	3.789249e-71	6.239287e+0	RYR2,TPM1,UCN	VertebrateAncestor	68.328
GO.Biological.Process	GO:0006359	regulation.of.transcription.from.RNA.polymerase.III.promoter	125	1.429118e-72	1.845992e-68	1.476793e-70	1.278010e+1	RPTOR,ZNF143	VertebrateAncestor	67.7338
GO.Biological.Process	GO:0051235	maintenance.of.location	126	2.440657e-72	3.152597e-68	2.502061e-70	5.315373e+0	FLNA,GRIK5,SYNE1,TLN2	VertebrateAncestor	67.5013
GO.Biological.Process	GO:0090286	cytoskeletal.anchoring.at.nuclear.membrane	127	3.749147e-72	4.842773e-68	3.813207e-70	2.692322e+1	SYNE1	VertebrateAncestor	67.3149
GO.Biological.Process	GO:0003208	cardiac.ventricle.morphogenesis	128	1.896837e-70	2.450144e-66	1.914175e-68	4.687196e+0	LRP2,MYH6,MYH7,NOTCH1,RYR2,TPM1,UBE4B	VertebrateAncestor	65.6108
GO.Biological.Process	GO:0044803	multi-organism.membrane.organization	129	6.200410e-70	8.009070e-66	6.208581e-68	1.515575e+1	CHMP6	VertebrateAncestor	65.0964
GO.Biological.Process	GO:0034227	tRNA.thio-modification	130	2.670027e-69	3.448874e-65	2.652980e-67	8.373157e+1	TRMU	VertebrateAncestor	64.4623
GO.Biological.Process	GO:1902580	single-organism.cellular.localization	131	5.132774e-69	6.630004e-65	5.061072e-67	2.212453e+0	ACACB,ACTN2,AMN,ARL6IP1,BBS7,CPT1B,DCHS1,DST,DYNC1H1,ENSG00000260342,FLNA,GRIK5,HSP90AA1,HSPD1,IPO7,KIF1B,LAMA5,LRP4,MACF1,MYH9,MYO7A,NCKIPSD,PEX2,RFTN2,RPL13,RPS15A,SCRIB,SMURF1,SPG7,SPTBN1,TTC21B	VertebrateAncestor	64.1785
GO.Biological.Process	GO:0000281	mitotic.cytokinesis	132	5.601717e-69	7.235738e-65	5.481620e-67	9.288366e+0	SPTBN1	VertebrateAncestor	64.1405
GO.Biological.Process	GO:0009386	translational.attenuation	133	5.876757e-69	7.591007e-65	5.707524e-67	1.404687e+2	TRAP1	VertebrateAncestor	64.1197
GO.Biological.Process	GO:1903514	calcium.ion.transport.from.endoplasmic.reticulum.to.cytosol	134	8.247127e-69	1.065281e-64	7.949861e-67	2.481462e+1	RYR1,RYR2	VertebrateAncestor	63.9725
GO.Biological.Process	GO:0051146	striated.muscle.cell.differentiation	135	4.407856e-68	5.693628e-64	4.217502e-66	3.624804e+0	ACTN2,FLNC,MYH6,MYH9,MYOF,MYOM2,RYR1,TPM1,TTN	VertebrateAncestor	63.2446
GO.Biological.Process	GO:0019068	virion.assembly	136	5.962786e-68	7.702131e-64	5.663331e-66	1.432816e+1	CHMP6	VertebrateAncestor	63.1134
GO.Biological.Process	GO:0003015	heart.process	137	4.267935e-67	5.512892e-63	4.024008e-65	4.600534e+0	ATP1A3,MYH6,MYH7,RYR2,SCN1A,SGCG,TPM1,TTN	VertebrateAncestor	62.2586
GO.Biological.Process	GO:0034775	glutathione.transmembrane.transport	138	9.587225e-67	1.238382e-62	8.973782e-65	1.117695e+2	ABCC1	VertebrateAncestor	61.9071
GO.Biological.Process	GO:0006997	nucleus.organization	139	1.939795e-66	2.505633e-62	1.802614e-64	5.146893e+0	CHMP6,PSME4,SYNE1	VertebrateAncestor	61.6011
GO.Biological.Process	GO:0061099	negative.regulation.of.protein.tyrosine.kinase.activity	140	2.172617e-66	2.806369e-62	2.004550e-64	1.370622e+1	CHMP6	VertebrateAncestor	61.5519
GO.Biological.Process	GO:0031648	protein.destabilization	141	3.881129e-66	5.013254e-62	3.555500e-64	8.491584e+0	CREBBP,FBXL3,PEX2	VertebrateAncestor	61.2999
GO.Biological.Process	GO:0060448	dichotomous.subdivision.of.terminal.units.involved.in.lung.branching	142	7.573243e-66	9.782358e-62	6.888984e-64	6.511655e+1	CELSR1	VertebrateAncestor	61.0096
GO.Biological.Process	GO:0009611	response.to.wounding	143	8.747409e-66	1.129903e-61	7.901418e-64	2.477855e+0	CELSR1,DST,EPPK1,F11,F2,FLNA,ILK,ITPR3,MACF1,MTR,MYH2,MYH9,MYOF,NOTCH1,SCRIB,TPM1,TRPC3	VertebrateAncestor	60.947
GO.Biological.Process	GO:0072595	maintenance.of.protein.localization.in.organelle	144	9.720588e-66	1.255608e-61	8.719502e-64	1.659772e+1	GRIK5,SYNE1	VertebrateAncestor	60.9011
GO.Biological.Process	GO:0051457	maintenance.of.protein.location.in.nucleus	145	1.352348e-65	1.746828e-61	1.204709e-63	2.143437e+1	SYNE1	VertebrateAncestor	60.7577
GO.Biological.Process	GO:0034635	glutathione.transport	146	4.516390e-65	5.833821e-61	3.995768e-63	1.014177e+2	ABCC1	VertebrateAncestor	60.234
GO.Biological.Process	GO:0010970	transport.along.microtubule	147	5.116423e-64	6.608884e-60	4.495839e-62	5.268740e+0	DST,DYNC1H1,KIF1B,SPG7,TTC21B	VertebrateAncestor	59.1799
GO.Biological.Process	GO:0016579	protein.deubiquitination	148	5.356893e-64	6.919499e-60	4.675337e-62	3.595471e+0	ADRM1,ESR1,OTULIN,PSME4,SHMT2,TAF10,TRRAP,USP15,USP34	VertebrateAncestor	59.1599
GO.Biological.Process	GO:0097050	type.B.pancreatic.cell.apoptotic.process	149	5.908268e-64	7.631710e-60	5.121953e-62	4.868344e+1	RYR2	VertebrateAncestor	59.1174
GO.Biological.Process	GO:0010927	cellular.component.assembly.involved.in.morphogenesis	150	6.236488e-64	8.055672e-60	5.370448e-62	5.641462e+0	ACTN2,ILK,MYH6,MYOM2,TPM1,TTN	VertebrateAncestor	59.0939
GO.Biological.Process	GO:1903078	positive.regulation.of.protein.localization.to.plasma.membrane	151	7.813918e-64	1.009324e-59	6.684263e-62	6.845758e+0	LRP1,SPTBN1	VertebrateAncestor	58.996
GO.Biological.Process	GO:0043254	regulation.of.protein.complex.assembly	152	8.348064e-64	1.078319e-59	7.094207e-62	2.857614e+0	ARFIP2,BAIAP2,ESR1,HSP90AA1,NCKAP1,PSRC1,SPTBN1,SPTBN5,TRABD2A	VertebrateAncestor	58.9673
GO.Biological.Process	GO:0060750	epithelial.cell.proliferation.involved.in.mammary.gland.duct.elongation	153	9.128198e-64	1.179089e-59	7.706466e-62	2.010512e+1	ESR1	VertebrateAncestor	58.9285
GO.Biological.Process	GO:0071168	protein.localization.to.chromatin	154	1.035803e-63	1.337947e-59	8.687966e-62	2.006647e+1	ESR1	VertebrateAncestor	58.8736
GO.Biological.Process	GO:1902582	single-organism.intracellular.transport	155	1.904225e-63	2.459687e-59	1.586895e-61	2.535980e+0	ACACB,ARL6IP1,BBS7,CPT1B,DST,DYNC1H1,ENSG00000260342,HSP90AA1,HSPD1,IPO7,KIF1B,MYO7A,NCKIPSD,PEX2,RFTN2,RPL13,RPS15A,SCRIB,SPG7,SPTBN1,TTC21B	VertebrateAncestor	58.6091
GO.Biological.Process	GO:0045899	positive.regulation.of.RNA.polymerase.II.transcriptional.preinitiation.complex.assembly	156	2.135794e-63	2.758805e-59	1.768465e-61	1.984654e+1	ESR1	VertebrateAncestor	58.5593
GO.Biological.Process	GO:0060751	branch.elongation.involved.in.mammary.gland.duct.branching	157	2.670740e-63	3.449795e-59	2.197322e-61	1.977908e+1	ESR1	VertebrateAncestor	58.4622
GO.Biological.Process	GO:0031365	N-terminal.protein.amino.acid.modification	158	3.858796e-63	4.984407e-59	3.154688e-61	1.390822e+1	CREBBP	VertebrateAncestor	58.3024
GO.Biological.Process	GO:0070900	mitochondrial.tRNA.modification	159	6.106600e-63	7.887895e-59	4.960940e-61	3.710998e+1	HSD17B10,TRMU	VertebrateAncestor	58.103
GO.Biological.Process	GO:0002223	stimulatory.C-type.lectin.receptor.signaling.pathway	160	1.037979e-62	1.340757e-58	8.379734e-61	6.111370e+0	CREBBP,MUC5AC,MUC5B,MUC6,PSME4	VertebrateAncestor	57.8726
GO.Biological.Process	GO:0045945	positive.regulation.of.transcription.from.RNA.polymerase.III.promoter	161	1.087934e-62	1.405284e-58	8.728474e-61	1.586542e+1	RPTOR	VertebrateAncestor	57.8522
GO.Biological.Process	GO:0009051	pentose-phosphate.shunt,.oxidative.branch	162	1.318507e-62	1.703115e-58	1.051306e-60	1.059079e+2	PGD	VertebrateAncestor	57.7688
GO.Biological.Process	GO:0060527	prostate.epithelial.cord.arborization.involved.in.prostate.glandular.acinus.morphogenesis	163	5.002163e-62	6.461294e-58	3.963984e-60	1.891452e+1	ESR1	VertebrateAncestor	57.1897
GO.Biological.Process	GO:0060029	convergent.extension.involved.in.organogenesis	164	5.139737e-62	6.638998e-58	4.048170e-60	2.594852e+1	FRZB	VertebrateAncestor	57.1779
GO.Biological.Process	GO:0060523	prostate.epithelial.cord.elongation	165	6.143781e-62	7.935922e-58	4.809650e-60	1.885523e+1	ESR1	VertebrateAncestor	57.1004
GO.Biological.Process	GO:0002220	innate.immune.response.activating.cell.surface.receptor.signaling.pathway	166	8.240230e-62	1.064391e-57	6.411991e-60	6.005698e+0	CREBBP,MUC5AC,MUC5B,MUC6,PSME4	VertebrateAncestor	56.9729
GO.Biological.Process	GO:0015889	cobalamin.transport	167	1.244054e-61	1.606945e-57	9.622422e-60	2.365060e+1	ABCC1,AMN	VertebrateAncestor	56.794
GO.Biological.Process	GO:0007517	muscle.organ.development	168	3.338905e-61	4.312864e-57	2.567181e-59	2.804316e+0	LAMA5,LRP2,MYH6,MYH7,MYOM2,NEB,NOTCH1,RYR1,RYR2,SGCG,TPM1,TTN,UBE4B,ZFHX3	VertebrateAncestor	56.3652
GO.Biological.Process	GO:2000360	negative.regulation.of.binding.of.sperm.to.zona.pellucida	169	4.669654e-61	6.031792e-57	3.569108e-59	4.236011e+1	ZP4	VertebrateAncestor	56.2196
GO.Biological.Process	GO:0070646	protein.modification.by.small.protein.removal	170	4.912938e-61	6.346042e-57	3.732966e-59	3.462183e+0	ADRM1,ESR1,OTULIN,PSME4,SHMT2,TAF10,TRRAP,USP15,USP34	VertebrateAncestor	56.1975
GO.Biological.Process	GO:0048729	tissue.morphogenesis	171	5.202454e-61	6.720010e-57	3.929830e-59	2.187387e+0	BBS7,CA9,CELSR1,DCHS1,ESR1,FAT4,FLNA,FOXN4,FREM2,FRZB,ILK,LAMA5,LRP2,MYH6,MYH7,NOTCH1,RYR2,SCRIB,SETD2,TPM1,TTN,UBE4B	VertebrateAncestor	56.1726
GO.Biological.Process	GO:0051209	release.of.sequestered.calcium.ion.into.cytosol	172	1.888706e-60	2.439642e-56	1.418396e-58	7.836221e+0	ITPR3,RYR1,RYR2,RYR3	VertebrateAncestor	55.6127
GO.Biological.Process	GO:0019521	D-gluconate.metabolic.process	173	2.130890e-60	2.752471e-56	1.591023e-58	9.252082e+1	PGD	VertebrateAncestor	55.5603
GO.Biological.Process	GO:0009235	cobalamin.metabolic.process	174	2.534722e-60	3.274100e-56	1.881667e-58	1.129747e+1	ABCC1,AMN,MTR	VertebrateAncestor	55.4849
GO.Biological.Process	GO:0003220	left.ventricular.cardiac.muscle.tissue.morphogenesis	175	3.380869e-60	4.367068e-56	2.495468e-58	4.064373e+1	RYR2	VertebrateAncestor	55.3598
GO.Biological.Process	GO:1905114	cell.surface.receptor.signaling.pathway.involved.in.cell-cell.signaling	176	3.949560e-60	5.101647e-56	2.898663e-58	2.471741e+0	CELSR1,CELSR2,CELSR3,FRZB,GRIK5,LRP4,MACF1,MAPK8IP2,OTULIN,PSME4,RYR2,SMURF1,TRABD2A,USP34	VertebrateAncestor	55.2923
GO.Biological.Process	GO:1902905	positive.regulation.of.supramolecular.fiber.organization	177	5.227906e-60	6.752886e-56	3.815190e-58	4.117381e+0	ACTN2,BAIAP2,NCKAP1,PSRC1,TPM1	VertebrateAncestor	55.1705
GO.Biological.Process	GO:0006888	ER.to.Golgi.vesicle-mediated.transport	178	6.709968e-60	8.667266e-56	4.869250e-58	4.472069e+0	DYNC1H1,F2,NRBP2,SEC16A,SPTBN1,SPTBN5	VertebrateAncestor	55.0621
GO.Biological.Process	GO:0007080	mitotic.metaphase.plate.congression	179	9.904736e-60	1.279395e-55	7.147457e-58	1.051058e+1	CHMP6,PSRC1	VertebrateAncestor	54.893
GO.Biological.Process	GO:0000053	argininosuccinate.metabolic.process	180	1.259110e-59	1.626392e-55	9.035513e-58	1.074985e+2	ASS1	VertebrateAncestor	54.7888
GO.Biological.Process	GO:0001547	antral.ovarian.follicle.growth	181	1.558315e-59	2.012875e-55	1.112086e-57	1.732297e+1	ESR1	VertebrateAncestor	54.6962
GO.Biological.Process	GO:2000359	regulation.of.binding.of.sperm.to.zona.pellucida	182	2.416002e-59	3.120750e-55	1.714698e-57	3.900594e+1	ZP4	VertebrateAncestor	54.5057
GO.Biological.Process	GO:0034504	protein.localization.to.nucleus	183	2.715228e-59	3.507260e-55	1.916536e-57	3.730474e+0	IPO7,NCKIPSD,SPTBN1,SYNE1,XPO1	VertebrateAncestor	54.455
GO.Biological.Process	GO:0070525	tRNA.threonylcarbamoyladenosine.metabolic.process	184	2.829964e-59	3.655464e-55	1.986665e-57	3.149993e+1	HSD17B10,TRMU	VertebrateAncestor	54.4371
GO.Biological.Process	GO:1904377	positive.regulation.of.protein.localization.to.cell.periphery	185	5.717895e-59	7.385805e-55	3.992327e-57	6.192865e+0	LRP1,SPTBN1	VertebrateAncestor	54.1316
GO.Biological.Process	GO:0046471	phosphatidylglycerol.metabolic.process	186	9.948450e-59	1.285041e-54	6.908824e-57	1.395459e+1	CDS1,PGS1,PLA2G4B	VertebrateAncestor	53.8911
GO.Biological.Process	GO:0061640	cytoskeleton-dependent.cytokinesis	187	1.740193e-58	2.247807e-54	1.202036e-56	7.307075e+0	SPTBN1	VertebrateAncestor	53.6482
GO.Biological.Process	GO:0009790	embryo.development	188	1.861280e-58	2.404215e-54	1.278838e-56	1.867172e+0	AATF,ANKRD11,BBS7,BIRC6,CELSR1,CREBBP,DCHS1,FOXN4,FRZB,LAMA5,LRP2,LRP4,MYH6,MYH9,MYO7A,NOTCH1,PGAP1,RYR2,SCRIB,SETD2,TPM1	VertebrateAncestor	53.619
GO.Biological.Process	GO:0032743	positive.regulation.of.interleukin-2.production	189	2.966883e-58	3.832323e-54	2.027684e-56	7.267800e+0	SPTBN1	VertebrateAncestor	53.4165
GO.Biological.Process	GO:0002922	positive.regulation.of.humoral.immune.response	190	4.868736e-58	6.288946e-54	3.309972e-56	2.492997e+1	HPX,ZP4	VertebrateAncestor	53.2014
GO.Biological.Process	GO:0060467	negative.regulation.of.fertilization	191	5.153770e-58	6.657125e-54	3.485406e-56	3.658446e+1	ZP4	VertebrateAncestor	53.1767
GO.Biological.Process	GO:0045898	regulation.of.RNA.polymerase.II.transcriptional.preinitiation.complex.assembly	192	5.680272e-57	7.337207e-53	3.821462e-55	1.581967e+1	ESR1	VertebrateAncestor	52.1345
GO.Biological.Process	GO:0042249	establishment.of.planar.polarity.of.embryonic.epithelium	193	8.029775e-57	1.037206e-52	5.374125e-55	4.108893e+1	CELSR1	VertebrateAncestor	51.9841
GO.Biological.Process	GO:0048662	negative.regulation.of.smooth.muscle.cell.proliferation	194	9.074267e-57	1.172123e-52	6.041871e-55	7.270506e+0	ILK,TPM1	VertebrateAncestor	51.931
GO.Biological.Process	GO:0060122	inner.ear.receptor.stereocilium.organization	195	1.102351e-56	1.423907e-52	7.302086e-55	1.142918e+1	CDH23,FAT4,MYO7A,SCRIB	VertebrateAncestor	51.8465
GO.Biological.Process	GO:0045088	regulation.of.innate.immune.response	196	2.303713e-56	2.975706e-52	1.518217e-54	2.949287e+0	CREBBP,ESR1,HPX,HSPD1,MUC5AC,MUC5B,MUC6,OTULIN,PSME4,SCRIB	VertebrateAncestor	51.5264
GO.Biological.Process	GO:1903799	negative.regulation.of.production.of.miRNAs.involved.in.gene.silencing.by.miRNA	197	2.940516e-56	3.798265e-52	1.928053e-54	1.542295e+1	ESR1	VertebrateAncestor	51.4204
GO.Biological.Process	GO:0070296	sarcoplasmic.reticulum.calcium.ion.transport	198	3.152310e-56	4.071839e-52	2.056484e-54	1.585362e+1	RYR1,RYR2	VertebrateAncestor	51.3902
GO.Biological.Process	GO:0060745	mammary.gland.branching.involved.in.pregnancy	199	3.417300e-56	4.414126e-52	2.218154e-54	1.538716e+1	ESR1	VertebrateAncestor	51.3552
GO.Biological.Process	GO:0055002	striated.muscle.cell.development	200	5.853741e-56	7.561277e-52	3.780639e-54	4.280342e+0	ACTN2,FLNC,MYH6,MYOM2,RYR1,TPM1,TTN	VertebrateAncestor	51.1214
GO.Biological.Process	GO:0071391	cellular.response.to.estrogen.stimulus	201	6.757827e-56	8.729085e-52	4.342828e-54	1.522573e+1	ESR1	VertebrateAncestor	51.059
GO.Biological.Process	GO:1901896	positive.regulation.of.calcium-transporting.ATPase.activity	202	8.137341e-56	1.051100e-51	5.203467e-54	3.289638e+1	RYR2	VertebrateAncestor	50.9784
GO.Biological.Process	GO:0043201	response.to.leucine	203	8.953107e-56	1.156473e-51	5.696910e-54	1.267083e+1	RPTOR	VertebrateAncestor	50.9369
GO.Biological.Process	GO:0019322	pentose.biosynthetic.process	204	1.142503e-55	1.475771e-51	7.234172e-54	6.922512e+1	PGD	VertebrateAncestor	50.831
GO.Biological.Process	GO:1903779	regulation.of.cardiac.conduction	205	1.540260e-55	1.989554e-51	9.705141e-54	5.435659e+0	ATP1A3,FLNA,ITPR3,RYR1,RYR2,RYR3	VertebrateAncestor	50.7012
GO.Biological.Process	GO:0006506	GPI.anchor.biosynthetic.process	206	2.034317e-55	2.627727e-51	1.275596e-53	1.539699e+1	PGAP1	VertebrateAncestor	50.5804
GO.Biological.Process	GO:0007520	myoblast.fusion	207	2.252545e-55	2.909612e-51	1.405610e-53	1.076056e+1	MYH9,MYOF	VertebrateAncestor	50.5362
GO.Biological.Process	GO:0070431	nucleotide-binding.oligomerization.domain.containing.2.signaling.pathway	208	2.529254e-55	3.267037e-51	1.570691e-53	2.138097e+1	OTULIN	VertebrateAncestor	50.4858
GO.Biological.Process	GO:1904059	regulation.of.locomotor.rhythm	209	3.480931e-55	4.496319e-51	2.151349e-53	2.506057e+1	ZFHX3	VertebrateAncestor	50.3471
GO.Biological.Process	GO:0007032	endosome.organization	210	3.706143e-55	4.787225e-51	2.279631e-53	7.341042e+0	CHMP6,DNAJC13,RILP,WASHC4	VertebrateAncestor	50.3199
GO.Biological.Process	GO:0098910	regulation.of.atrial.cardiac.muscle.cell.action.potential	211	3.790818e-55	4.896600e-51	2.320663e-53	2.122529e+1	FLNA,RYR2	VertebrateAncestor	50.3101
GO.Biological.Process	GO:0048193	Golgi.vesicle.transport	212	5.403364e-55	6.979525e-51	3.292229e-53	3.042385e+0	AMN,DYNC1H1,F2,MACF1,MON2,NRBP2,SEC16A,SPTBN1,SPTBN5	VertebrateAncestor	50.1562
GO.Biological.Process	GO:0002757	immune.response-activating.signal.transduction	213	6.423297e-55	8.296973e-51	3.895292e-53	2.878483e+0	BAIAP2,CREBBP,HSP90AA1,HSPD1,MUC5AC,MUC5B,MUC6,MYH2,NCKAP1,NCKIPSD,OTULIN,PSME4,RFTN2	VertebrateAncestor	50.0811
GO.Biological.Process	GO:0006505	GPI.anchor.metabolic.process	214	8.316102e-55	1.074191e-50	5.019584e-53	1.506034e+1	PGAP1	VertebrateAncestor	49.9689
GO.Biological.Process	GO:0007015	actin.filament.organization	215	8.740116e-55	1.128961e-50	5.250980e-53	3.536304e+0	BAIAP2,FAT1,FLNA,MYOM2,TPM1,TPM2,TTN	VertebrateAncestor	49.9473
GO.Biological.Process	GO:0030705	cytoskeleton-dependent.intracellular.transport	216	1.069835e-54	1.381906e-50	6.397712e-53	4.477222e+0	DST,DYNC1H1,KIF1B,SPG7,TTC21B	VertebrateAncestor	49.8595
GO.Biological.Process	GO:0071709	membrane.assembly	217	1.671261e-54	2.158768e-50	9.948239e-53	6.186133e+0	LRP4,SPTBN1	VertebrateAncestor	49.6658
GO.Biological.Process	GO:0050778	positive.regulation.of.immune.response	218	1.747994e-54	2.257884e-50	1.035727e-52	2.490177e+0	BAIAP2,CREBBP,HPX,HSP90AA1,HSPD1,MUC5AC,MUC5B,MUC6,MYH2,NCKAP1,NCKIPSD,OTULIN,PSME4,RFTN2,RIF1,ZP4	VertebrateAncestor	49.6463
GO.Biological.Process	GO:0033365	protein.localization.to.organelle	219	2.544369e-54	3.286561e-50	1.500713e-52	2.425609e+0	ESR1,FAM83H,GRIK5,HSP90AA1,HSPD1,IPO7,NCKIPSD,PEX2,RPL13,RPS15A,RYR2,SCRIB,SMURF1,SPTBN1,SYNE1,TIMM10B,TOLLIP,TTC21B,XPO1	VertebrateAncestor	49.4833
GO.Biological.Process	GO:0060965	negative.regulation.of.gene.silencing.by.miRNA	220	3.357447e-54	4.336814e-50	1.971279e-52	1.433102e+1	ESR1	VertebrateAncestor	49.3628
GO.Biological.Process	GO:0055001	muscle.cell.development	221	3.869562e-54	4.998313e-50	2.261680e-52	3.861719e+0	ACTN2,FLNC,MYH6,MYOM2,NOTCH1,RYR1,SGCG,TPM1,TRIM54,TTN	VertebrateAncestor	49.3012
GO.Biological.Process	GO:0007163	establishment.or.maintenance.of.cell.polarity	222	4.108108e-54	5.306443e-50	2.390290e-52	3.391466e+0	CDC42BPB,CKAP5,DST,FAT1,ILK,MARK3,MYH9,SCRIB,WEE1	VertebrateAncestor	49.2752
GO.Biological.Process	GO:0044091	membrane.biogenesis	223	4.993059e-54	6.449534e-50	2.892168e-52	6.120205e+0	LRP4,SPTBN1	VertebrateAncestor	49.1905
GO.Biological.Process	GO:0001539	cilium.or.flagellum-dependent.cell.motility	224	6.906179e-54	8.920711e-50	3.982460e-52	1.008808e+1	DNAH17,DNAH6,DNAH7	VertebrateAncestor	49.0496
GO.Biological.Process	GO:1902904	negative.regulation.of.supramolecular.fiber.organization	225	1.336201e-53	1.725971e-49	7.670981e-52	4.636524e+0	SPTBN1,SPTBN5,TRIM54	VertebrateAncestor	48.763
GO.Biological.Process	GO:0051496	positive.regulation.of.stress.fiber.assembly	226	2.353819e-53	3.040428e-49	1.345322e-51	6.935503e+0	TPM1	VertebrateAncestor	48.5171
GO.Biological.Process	GO:0099039	sphingolipid.translocation	227	2.519695e-53	3.254690e-49	1.433784e-51	5.109608e+1	ABCC1	VertebrateAncestor	48.4875
GO.Biological.Process	GO:0002758	innate.immune.response-activating.signal.transduction	228	5.461302e-53	7.054364e-49	3.094019e-51	3.648907e+0	CREBBP,HSPD1,MUC5AC,MUC5B,MUC6,OTULIN,PSME4	VertebrateAncestor	48.1515
GO.Biological.Process	GO:0042060	wound.healing	229	7.486919e-53	9.670853e-49	4.223080e-51	2.460425e+0	CELSR1,EPPK1,F11,F2,FLNA,ILK,ITPR3,MACF1,MYH2,MYH9,MYOF,NOTCH1,SCRIB,TPM1,TRPC3	VertebrateAncestor	48.0145
GO.Biological.Process	GO:0086029	Purkinje.myocyte.to.ventricular.cardiac.muscle.cell.signaling	230	7.834988e-53	1.012045e-48	4.400197e-51	2.846263e+1	RYR2	VertebrateAncestor	47.9948
GO.Biological.Process	GO:1903751	negative.regulation.of.intrinsic.apoptotic.signaling.pathway.in.response.to.hydrogen.peroxide	231	9.241177e-53	1.193683e-48	5.167458e-51	5.338583e+1	TRAP1	VertebrateAncestor	47.9231
GO.Biological.Process	GO:0006767	water-soluble.vitamin.metabolic.process	232	2.855925e-52	3.688998e-48	1.590085e-50	5.615061e+0	ABCC1,ACACB,ALDH1L2,AMN,FASN,MTR,SHMT2,TKTL1	VertebrateAncestor	47.4331
GO.Biological.Process	GO:0030520	intracellular.estrogen.receptor.signaling.pathway	233	8.093114e-52	1.045388e-47	4.486642e-50	1.315660e+1	ESR1	VertebrateAncestor	46.9807
GO.Biological.Process	GO:0060149	negative.regulation.of.posttranscriptional.gene.silencing	234	1.101880e-51	1.423298e-47	6.082472e-50	1.309325e+1	ESR1	VertebrateAncestor	46.8467
GO.Biological.Process	GO:0060967	negative.regulation.of.gene.silencing.by.RNA	234	1.101880e-51	1.423298e-47	6.082472e-50	1.309325e+1	ESR1	VertebrateAncestor	46.8467
GO.Biological.Process	GO:0061418	regulation.of.transcription.from.RNA.polymerase.II.promoter.in.response.to.hypoxia	236	1.244162e-51	1.607084e-47	6.809678e-50	6.886833e+0	CA9,CREBBP,NOTCH1,PSME4	VertebrateAncestor	46.794
GO.Biological.Process	GO:0050776	regulation.of.immune.response	237	2.767802e-51	3.575170e-47	1.508510e-49	2.119823e+0	BAIAP2,CREBBP,ESR1,F2,HPX,HSP90AA1,HSPD1,MUC5AC,MUC5B,MUC6,MYH2,NCKAP1,NCKIPSD,OTULIN,PSME4,RFTN2,RIF1,SCRIB,SLC39A10,ZP4	VertebrateAncestor	46.4467
GO.Biological.Process	GO:0090066	regulation.of.anatomical.structure.size	238	4.411830e-51	5.698761e-47	2.394437e-49	2.341487e+0	ACTN2,ARFIP2,BAIAP2,ILK,MACF1,NCKAP1,NEB,RILP,RPTOR,SPTBN1,SPTBN5,UCN	VertebrateAncestor	46.2442
GO.Biological.Process	GO:0021871	forebrain.regionalization	239	4.695796e-51	6.065560e-47	2.537891e-49	7.326091e+0	PGAP1,TTC21B	VertebrateAncestor	46.2171
GO.Biological.Process	GO:0033013	tetrapyrrole.metabolic.process	240	5.301456e-51	6.847891e-47	2.853288e-49	7.625210e+0	ABCC1,AMN,HPX,MTR	VertebrateAncestor	46.1644
GO.Biological.Process	GO:0002429	immune.response-activating.cell.surface.receptor.signaling.pathway	241	5.624342e-51	7.264963e-47	3.014507e-49	3.210499e+0	BAIAP2,CREBBP,HSP90AA1,MUC5AC,MUC5B,MUC6,MYH2,NCKAP1,NCKIPSD,PSME4,RFTN2	VertebrateAncestor	46.1388
GO.Biological.Process	GO:0006098	pentose-phosphate.shunt	242	7.945170e-51	1.026278e-46	4.240817e-49	1.710790e+1	PGD,RPE	VertebrateAncestor	45.9887
GO.Biological.Process	GO:0007178	transmembrane.receptor.protein.serine/threonine.kinase.signaling.pathway	243	8.178162e-51	1.056373e-46	4.347215e-49	3.182649e+0	BMP8A,LRP4,RYR2,SMURF1,SPTBN1,USP15	VertebrateAncestor	45.9762
GO.Biological.Process	GO:0002218	activation.of.innate.immune.response	244	1.206602e-50	1.558568e-46	6.387573e-49	3.517435e+0	CREBBP,HSPD1,MUC5AC,MUC5B,MUC6,OTULIN,PSME4	VertebrateAncestor	45.8073
GO.Biological.Process	GO:0045777	positive.regulation.of.blood.pressure	245	1.260199e-50	1.627799e-46	6.644078e-49	6.480155e+0	TPM1	VertebrateAncestor	45.7884
GO.Biological.Process	GO:0003341	cilium.movement	246	1.515128e-50	1.957091e-46	7.955654e-49	6.394316e+0	DNAH17,DNAH5,DNAH7,DNAH9,DNHD1	VertebrateAncestor	45.7084
GO.Biological.Process	GO:0051495	positive.regulation.of.cytoskeleton.organization	247	2.391536e-50	3.089147e-46	1.250667e-48	3.543151e+0	ACTN2,BAIAP2,NCKAP1,PSRC1,TPM1	VertebrateAncestor	45.5102
GO.Biological.Process	GO:0086068	Purkinje.myocyte.to.ventricular.cardiac.muscle.cell.communication	248	4.458991e-50	5.759679e-46	2.322451e-48	2.488454e+1	RYR2	VertebrateAncestor	45.2396
GO.Biological.Process	GO:0060525	prostate.glandular.acinus.development	249	5.048598e-50	6.521274e-46	2.618986e-48	1.119486e+1	ESR1,NOTCH1	VertebrateAncestor	45.1857
GO.Biological.Process	GO:0090646	mitochondrial.tRNA.processing	250	5.986621e-50	7.732918e-46	3.093167e-48	2.067231e+1	HSD17B10,TRMU	VertebrateAncestor	45.1117
GO.Biological.Process	GO:0097435	supramolecular.fiber.organization	251	9.288632e-50	1.199813e-45	4.780130e-48	2.680992e+0	ACTN2,BAIAP2,CKAP5,DYNC1H1,EPPK1,FAT1,FLNA,ILK,MYH6,MYOM2,TPM1,TPM2,TTN	VertebrateAncestor	44.9209
GO.Biological.Process	GO:0060304	regulation.of.phosphatidylinositol.dephosphorylation	252	9.378287e-50	1.211393e-45	4.807116e-48	4.808055e+1	CHRM5	VertebrateAncestor	44.9167
GO.Biological.Process	GO:0060478	acrosomal.vesicle.exocytosis	253	9.816996e-50	1.268061e-45	5.012100e-48	2.447092e+1	ZP4	VertebrateAncestor	44.8969
GO.Biological.Process	GO:0000910	cytokinesis	254	1.122942e-49	1.450504e-45	5.710646e-48	4.966775e+0	MYH9,SPTBN1	VertebrateAncestor	44.8385
GO.Biological.Process	GO:0007339	binding.of.sperm.to.zona.pellucida	255	1.771287e-49	2.287971e-45	8.972437e-48	1.273253e+1	ACR,ZP4	VertebrateAncestor	44.6405
GO.Biological.Process	GO:0060737	prostate.gland.morphogenetic.growth	256	5.147730e-49	6.649323e-45	2.597392e-47	1.188816e+1	ESR1	VertebrateAncestor	44.1772
GO.Biological.Process	GO:0032233	positive.regulation.of.actin.filament.bundle.assembly	257	5.388686e-49	6.960566e-45	2.708391e-47	6.219988e+0	TPM1	VertebrateAncestor	44.1574
GO.Biological.Process	GO:0051494	negative.regulation.of.cytoskeleton.organization	258	5.465011e-49	7.059155e-45	2.736106e-47	4.249023e+0	SPTBN1,SPTBN5,TRIM54	VertebrateAncestor	44.1512
GO.Biological.Process	GO:0071312	cellular.response.to.alkaloid	259	6.337409e-49	8.186031e-45	3.160630e-47	6.351044e+0	RYR1,RYR2,RYR3	VertebrateAncestor	44.0869
GO.Biological.Process	GO:0034629	cellular.protein.complex.localization	260	1.110254e-48	1.434115e-44	5.515827e-47	1.045299e+1	EXOC3L4,TNFAIP2	VertebrateAncestor	43.8434
GO.Biological.Process	GO:0007176	regulation.of.epidermal.growth.factor-activated.receptor.activity	261	2.289285e-48	2.957069e-44	1.132977e-46	8.103230e+0	CHMP6	VertebrateAncestor	43.5291
GO.Biological.Process	GO:0060687	regulation.of.branching.involved.in.prostate.gland.morphogenesis	262	2.536681e-48	3.276631e-44	1.250622e-46	1.159250e+1	ESR1	VertebrateAncestor	43.4846
GO.Biological.Process	GO:0030540	female.genitalia.development	263	3.896414e-48	5.032998e-44	1.913687e-46	8.459665e+0	ESR1,LRP2	VertebrateAncestor	43.2982
GO.Biological.Process	GO:0098907	regulation.of.SA.node.cell.action.potential	264	4.806458e-48	6.208502e-44	2.351705e-46	2.252607e+1	RYR2	VertebrateAncestor	43.207
GO.Biological.Process	GO:0048738	cardiac.muscle.tissue.development	265	1.018785e-47	1.315965e-43	4.965904e-46	2.989948e+0	ACTN2,LRP2,MYH6,MYH7,NOTCH1,RYR2,SGCG,TPM1,TTN,UBE4B	VertebrateAncestor	42.8808
GO.Biological.Process	GO:0007340	acrosome.reaction	266	1.362368e-47	1.759771e-43	6.615679e-46	1.186770e+1	ACR,ZP4	VertebrateAncestor	42.7545
GO.Biological.Process	GO:0002253	activation.of.immune.response	267	1.477790e-47	1.908861e-43	7.149293e-46	2.631165e+0	BAIAP2,CREBBP,HSP90AA1,HSPD1,MUC5AC,MUC5B,MUC6,MYH2,NCKAP1,NCKIPSD,OTULIN,PSME4,RFTN2	VertebrateAncestor	42.7192
GO.Biological.Process	GO:0008090	retrograde.axonal.transport	268	1.549680e-47	2.001722e-43	7.469111e-46	1.927833e+1	DST	VertebrateAncestor	42.6986
GO.Biological.Process	GO:0072657	protein.localization.to.membrane	269	1.735847e-47	2.242194e-43	8.335292e-46	2.601826e+0	ACTN2,AMN,ARL6IP1,DCHS1,ENSG00000260342,FLNA,GRIK5,HSP90AA1,LAMA5,LRP4,MACF1,RFTN2,RPL13,RPS15A,SCRIB,SMURF1,SPTBN1	VertebrateAncestor	42.6493
GO.Biological.Process	GO:0048105	establishment.of.body.hair.planar.orientation	270	1.908760e-47	2.465545e-43	9.131649e-46	2.532518e+1	CELSR1	VertebrateAncestor	42.6081
GO.Biological.Process	GO:0001523	retinoid.metabolic.process	271	5.069318e-47	6.548038e-43	2.416250e-45	5.121956e+0	CYP26A1,CYP26C1,DHRS9,LRP1,LRP2	VertebrateAncestor	42.1839
GO.Biological.Process	GO:0017038	protein.import	272	6.048181e-47	7.812435e-43	2.872219e-45	3.566932e+0	HSP90AA1,HSPD1,IPO7,NCKIPSD,PEX2,SPTBN1	VertebrateAncestor	42.1072
GO.Biological.Process	GO:0031929	TOR.signaling	273	6.238198e-47	8.057880e-43	2.951605e-45	9.443957e+0	RPTOR	VertebrateAncestor	42.0938
GO.Biological.Process	GO:0072594	establishment.of.protein.localization.to.organelle	274	1.001794e-46	1.294017e-42	4.722691e-45	2.794214e+0	HSP90AA1,HSPD1,IPO7,NCKIPSD,PEX2,RPL13,RPS15A,RYR2,SCRIB,SMURF1,SPTBN1,TIMM10B	VertebrateAncestor	41.8881
GO.Biological.Process	GO:0008016	regulation.of.heart.contraction	275	1.097191e-46	1.417242e-42	5.153606e-45	2.713232e+0	ATP1A3,FLNA,FOXN4,ITPR3,MYH6,MYH7,RYR1,RYR2,RYR3,TPM1,UCN	VertebrateAncestor	41.8486
GO.Biological.Process	GO:0051301	cell.division	276	1.822871e-46	2.354602e-42	8.531168e-45	2.326689e+0	AATF,BIRC6,CENPS,CHMP6,CKAP5,DYNC1H1,MYH9,NOTCH1,PSRC1,SPTBN1,WEE1	VertebrateAncestor	41.6281
GO.Biological.Process	GO:0008089	anterograde.axonal.transport	277	2.726678e-46	3.522050e-42	1.271498e-44	1.159398e+1	KIF1B,SPG7	VertebrateAncestor	41.4532
GO.Biological.Process	GO:0014910	regulation.of.smooth.muscle.cell.migration	278	4.897838e-46	6.326537e-42	2.275733e-44	4.806621e+0	ILK,LRP1,TPM1	VertebrateAncestor	41.1988
GO.Biological.Process	GO:0098904	regulation.of.AV.node.cell.action.potential	279	5.003773e-46	6.463374e-42	2.316621e-44	2.039723e+1	RYR2	VertebrateAncestor	41.1895
GO.Biological.Process	GO:0000963	mitochondrial.RNA.processing	280	5.285156e-46	6.826836e-42	2.438156e-44	1.725534e+1	HSD17B10,TRMU	VertebrateAncestor	41.1658
GO.Biological.Process	GO:0050957	equilibrioception	281	6.308385e-46	8.148541e-42	2.899837e-44	1.540730e+1	CDH23,MYO7A	VertebrateAncestor	41.0889
GO.Biological.Process	GO:0030036	actin.cytoskeleton.organization	282	7.581868e-46	9.793499e-42	3.472872e-44	2.372744e+0	ACTN2,ARFIP2,BAIAP2,CDC42BPB,FAT1,FLNA,MYH6,MYH9,MYOM2,SPTBN5,TPM1,TPM2,TTN	VertebrateAncestor	41.0091
GO.Biological.Process	GO:0016236	macroautophagy	283	1.147097e-45	1.481705e-41	5.235707e-44	4.523639e+0	CHMP6,PRKAG1,SMURF1,WDFY3	VertebrateAncestor	40.8292
GO.Biological.Process	GO:0031503	protein.complex.localization	284	1.766595e-45	2.281911e-41	8.034897e-44	5.874635e+0	EXOC3L4,TNFAIP2,TTC21B	VertebrateAncestor	40.6417
GO.Biological.Process	GO:0003044	regulation.of.systemic.arterial.blood.pressure.mediated.by.a.chemical.signal	285	2.524214e-45	3.260527e-41	1.144045e-43	5.665440e+0	TPM1	VertebrateAncestor	40.4867
GO.Biological.Process	GO:0060442	branching.involved.in.prostate.gland.morphogenesis	286	2.553469e-45	3.298316e-41	1.153257e-43	1.038625e+1	ESR1	VertebrateAncestor	40.4817
GO.Biological.Process	GO:0051180	vitamin.transport	287	3.199346e-45	4.132595e-41	1.439929e-43	8.742162e+0	ABCC1,AMN,LRP2	VertebrateAncestor	40.3838
GO.Biological.Process	GO:0031333	negative.regulation.of.protein.complex.assembly	288	4.148124e-45	5.358132e-41	1.860462e-43	4.129978e+0	SPTBN1,SPTBN5	VertebrateAncestor	40.271
GO.Biological.Process	GO:0008209	androgen.metabolic.process	289	4.205751e-45	5.432569e-41	1.879782e-43	7.697395e+0	DHRS9,ESR1	VertebrateAncestor	40.265
GO.Biological.Process	GO:0019682	glyceraldehyde-3-phosphate.metabolic.process	290	4.321980e-45	5.582702e-41	1.925070e-43	1.346993e+1	PGD,RPE	VertebrateAncestor	40.2532
GO.Biological.Process	GO:0007034	vacuolar.transport	291	4.656667e-45	6.015017e-41	2.067016e-43	4.595874e+0	CHMP6,RILP,SMURF1,SPTBN5	VertebrateAncestor	40.2208
GO.Biological.Process	GO:0002764	immune.response-regulating.signaling.pathway	292	6.825987e-45	8.817127e-41	3.019564e-43	2.544097e+0	BAIAP2,CREBBP,HSP90AA1,HSPD1,MUC5AC,MUC5B,MUC6,MYH2,NCKAP1,NCKIPSD,OTULIN,PSME4,RFTN2	VertebrateAncestor	40.0547
GO.Biological.Process	GO:0060261	positive.regulation.of.transcription.initiation.from.RNA.polymerase.II.promoter	293	1.091687e-44	1.410132e-40	4.812738e-43	1.014765e+1	ESR1	VertebrateAncestor	39.8507
GO.Biological.Process	GO:0000768	syncytium.formation.by.plasma.membrane.fusion	294	2.523090e-44	3.259075e-40	1.108529e-42	7.634547e+0	MYH9,MYOF	VertebrateAncestor	39.4869
GO.Biological.Process	GO:0051310	metaphase.plate.congression	295	3.138563e-44	4.054082e-40	1.374265e-42	6.746688e+0	CHMP6,PSRC1	VertebrateAncestor	39.3921
GO.Biological.Process	GO:0006949	syncytium.formation	296	3.666682e-44	4.736253e-40	1.600086e-42	7.595281e+0	MYH9,MYOF	VertebrateAncestor	39.3246
GO.Biological.Process	GO:2000272	negative.regulation.of.receptor.activity	297	3.975652e-44	5.135350e-40	1.729074e-42	7.125960e+0	CHMP6	VertebrateAncestor	39.2894
GO.Biological.Process	GO:0035672	oligopeptide.transmembrane.transport	298	5.923169e-44	7.650957e-40	2.567435e-42	2.938035e+1	ABCC1	VertebrateAncestor	39.1163
GO.Biological.Process	GO:0002027	regulation.of.heart.rate	299	6.055580e-44	7.821993e-40	2.616051e-42	3.712200e+0	MYH6,MYH7,RYR2,TPM1	VertebrateAncestor	39.1067
GO.Biological.Process	GO:0050732	negative.regulation.of.peptidyl-tyrosine.phosphorylation	300	1.020536e-43	1.318226e-39	4.394088e-42	7.037138e+0	CHMP6	VertebrateAncestor	38.88
GO.Biological.Process	GO:0097553	calcium.ion.transmembrane.import.into.cytosol	301	1.067345e-43	1.378690e-39	4.580364e-42	5.222822e+0	ITPR3,RYR1,RYR2,RYR3	VertebrateAncestor	38.8605
GO.Biological.Process	GO:0032929	negative.regulation.of.superoxide.anion.generation	302	3.183856e-43	4.112587e-39	1.361784e-41	5.202077e+1	AATF	VertebrateAncestor	38.3859
GO.Biological.Process	GO:0032008	positive.regulation.of.TOR.signaling	303	3.456276e-43	4.464472e-39	1.473423e-41	8.315256e+0	RPTOR	VertebrateAncestor	38.3502
GO.Biological.Process	GO:0019321	pentose.metabolic.process	304	3.874902e-43	5.005211e-39	1.646451e-41	1.240507e+1	PGD,RPE	VertebrateAncestor	38.3006
GO.Biological.Process	GO:0034329	cell.junction.assembly	305	6.193402e-43	8.000017e-39	2.622957e-41	3.605072e+0	ACTN2,FLNA,FLNC,ILK,LAMA5,PLEC,TLN2	VertebrateAncestor	38.0969
GO.Biological.Process	GO:0002098	tRNA.wobble.uridine.modification	306	8.709359e-43	1.124988e-38	3.676431e-41	2.082540e+1	TRMU	VertebrateAncestor	37.9489
GO.Biological.Process	GO:0051775	response.to.redox.state	307	9.088936e-43	1.174018e-38	3.824162e-41	1.735632e+1	RYR2	VertebrateAncestor	37.9303
GO.Biological.Process	GO:0030111	regulation.of.Wnt.signaling.pathway	308	1.194027e-42	1.542325e-38	5.007548e-41	2.386298e+0	BIRC8,ESR1,FRZB,ILK,LRP1,LRP4,MACF1,NOTCH1,PSME4,TRABD2A,USP34	VertebrateAncestor	37.8118
GO.Biological.Process	GO:0033598	mammary.gland.epithelial.cell.proliferation	309	1.376915e-42	1.778561e-38	5.755861e-41	9.388092e+0	ESR1	VertebrateAncestor	37.7499
GO.Biological.Process	GO:0044802	single-organism.membrane.organization	310	1.508192e-42	1.948132e-38	6.284296e-41	1.974524e+0	ABCC1,ACTN2,AMN,ARL6IP1,BAIAP2,DCHS1,ENSG00000260342,FAT4,FLNA,GRIK5,HSP90AA1,LAMA5,LRP4,MACF1,MYH2,MYOF,RFTN2,RPL13,RPS15A,SCRIB,SMURF1,SPG7,SPTBN1	VertebrateAncestor	37.7104
GO.Biological.Process	GO:0051156	glucose.6-phosphate.metabolic.process	311	1.989776e-42	2.570194e-38	8.264288e-41	1.203714e+1	PGD,RPE	VertebrateAncestor	37.59
GO.Biological.Process	GO:1904837	beta-catenin-TCF.complex.assembly	312	2.045583e-42	2.642280e-38	8.468845e-41	6.227149e+0	CREBBP,KMT2D,TRRAP	VertebrateAncestor	37.578
GO.Biological.Process	GO:0016101	diterpenoid.metabolic.process	313	2.334767e-42	3.015819e-38	9.635203e-41	4.593768e+0	CYP26A1,CYP26C1,DHRS9,LRP1,LRP2	VertebrateAncestor	37.5206
GO.Biological.Process	GO:0036159	inner.dynein.arm.assembly	314	9.623667e-42	1.243089e-37	3.958882e-40	1.969012e+1	DNAH7,DNHD1	VertebrateAncestor	36.9055
GO.Biological.Process	GO:0060026	convergent.extension	315	1.140452e-41	1.473122e-37	4.676577e-40	1.132817e+1	FRZB	VertebrateAncestor	36.8318
GO.Biological.Process	GO:1903076	regulation.of.protein.localization.to.plasma.membrane	316	1.241063e-41	1.603081e-37	5.073041e-40	4.255775e+0	LRP1,SPTBN1	VertebrateAncestor	36.795
GO.Biological.Process	GO:1900087	positive.regulation.of.G1/S.transition.of.mitotic.cell.cycle	317	1.663660e-41	2.148950e-37	6.779021e-40	7.847573e+0	RPTOR	VertebrateAncestor	36.6678
GO.Biological.Process	GO:0032049	cardiolipin.biosynthetic.process	318	1.735688e-41	2.241988e-37	7.050277e-40	3.852668e+1	PGS1	VertebrateAncestor	36.6494
GO.Biological.Process	GO:0045089	positive.regulation.of.innate.immune.response	319	2.121372e-41	2.740176e-37	8.589894e-40	2.947810e+0	CREBBP,HPX,HSPD1,MUC5AC,MUC5B,MUC6,OTULIN,PSME4	VertebrateAncestor	36.5622
GO.Biological.Process	GO:0003231	cardiac.ventricle.development	320	6.615719e-41	8.545524e-37	2.670476e-39	2.981852e+0	LRP2,MYH6,MYH7,NOTCH1,RYR2,TPM1,UBE4B	VertebrateAncestor	36.0683
GO.Biological.Process	GO:0006721	terpenoid.metabolic.process	321	6.939786e-41	8.964122e-37	2.792561e-39	4.435659e+0	CYP26A1,CYP26C1,DHRS9,LRP1,LRP2	VertebrateAncestor	36.0475
GO.Biological.Process	GO:0042445	hormone.metabolic.process	322	7.496288e-41	9.682955e-37	3.007129e-39	3.297218e+0	CYP26A1,CYP26C1,DHRS9,ESR1	VertebrateAncestor	36.014
GO.Biological.Process	GO:0047497	mitochondrion.transport.along.microtubule	323	1.263677e-40	1.632292e-36	5.053534e-39	1.181827e+1	KIF1B	VertebrateAncestor	35.7872
GO.Biological.Process	GO:1903798	regulation.of.production.of.miRNAs.involved.in.gene.silencing.by.miRNA	324	1.439346e-40	1.859203e-36	5.738282e-39	8.705915e+0	ESR1	VertebrateAncestor	35.7307
GO.Biological.Process	GO:0016197	endosomal.transport	325	1.479275e-40	1.910780e-36	5.879322e-39	3.068883e+0	CHMP6,CLTCL1,DENND5A,EHD4,MON2,RILP,SCRIB,WASHC4	VertebrateAncestor	35.7188
GO.Biological.Process	GO:0060271	cilium.assembly	326	1.711759e-40	2.211079e-36	6.782451e-39	2.754069e+0	BBS7,CELSR3,CKAP5,DNAH5,DNAH6,DNAH7,DNHD1,DYNC1H1,FLNA,GALNT11,HSP90AA1,LAMA5,NOTCH1,RILP,TTC21B	VertebrateAncestor	35.6554
GO.Biological.Process	GO:0060969	negative.regulation.of.gene.silencing	327	1.971107e-40	2.546079e-36	7.786174e-39	8.661399e+0	ESR1	VertebrateAncestor	35.5941
GO.Biological.Process	GO:0072329	monocarboxylic.acid.catabolic.process	328	3.193670e-40	4.125264e-36	1.257702e-38	4.656748e+0	CPT1B,CYP26A1,CYP26C1,PEX2	VertebrateAncestor	35.3845
GO.Biological.Process	GO:0070920	regulation.of.production.of.small.RNA.involved.in.gene.silencing.by.RNA	329	3.846505e-40	4.968531e-36	1.510192e-38	8.567400e+0	ESR1	VertebrateAncestor	35.3038
GO.Biological.Process	GO:0033198	response.to.ATP	330	4.160211e-40	5.373745e-36	1.628407e-38	9.351114e+0	RYR3,TRPC3	VertebrateAncestor	35.2697
GO.Biological.Process	GO:0003007	heart.morphogenesis	331	6.224025e-40	8.039573e-36	2.428874e-38	2.431261e+0	BBS7,DCHS1,FAT4,FOXN4,ILK,LRP2,MYH6,MYH7,NOTCH1,RYR1,RYR2,TPM1,TTN,UBE4B	VertebrateAncestor	35.0948
GO.Biological.Process	GO:0002768	immune.response-regulating.cell.surface.receptor.signaling.pathway	332	9.927689e-40	1.282360e-35	3.862529e-38	2.714137e+0	BAIAP2,CREBBP,HSP90AA1,MUC5AC,MUC5B,MUC6,MYH2,NCKAP1,NCKIPSD,PSME4,RFTN2	VertebrateAncestor	34.892
GO.Biological.Process	GO:0032663	regulation.of.interleukin-2.production	333	1.164316e-39	1.503947e-35	4.516357e-38	4.630368e+0	SPTBN1	VertebrateAncestor	34.8228
GO.Biological.Process	GO:0086064	cell.communication.by.electrical.coupling.involved.in.cardiac.conduction	334	1.456473e-39	1.881326e-35	5.632713e-38	8.945255e+0	ATP1A3,RYR2	VertebrateAncestor	34.7255
GO.Biological.Process	GO:0034614	cellular.response.to.reactive.oxygen.species	335	1.717902e-39	2.219014e-35	6.623922e-38	3.972959e+0	MTR,TPM1	VertebrateAncestor	34.6538
GO.Biological.Process	GO:0008360	regulation.of.cell.shape	336	1.899932e-39	2.454142e-35	7.303995e-38	3.309724e+0	BAIAP2,F2,MYH9,TPM1	VertebrateAncestor	34.6101
GO.Biological.Process	GO:0035461	vitamin.transmembrane.transport	337	2.486822e-39	3.212228e-35	9.531834e-38	2.228151e+1	ABCC1	VertebrateAncestor	34.4932
GO.Biological.Process	GO:0060736	prostate.gland.growth	338	3.370670e-39	4.353894e-35	1.288134e-37	7.371421e+0	ESR1,PSAP	VertebrateAncestor	34.3611
GO.Biological.Process	GO:0060260	regulation.of.transcription.initiation.from.RNA.polymerase.II.promoter	339	8.495117e-39	1.097314e-34	3.236915e-37	8.143745e+0	ESR1	VertebrateAncestor	33.9597
GO.Biological.Process	GO:0003206	cardiac.chamber.morphogenesis	340	8.965942e-39	1.158131e-34	3.406267e-37	2.876476e+0	LRP2,MYH6,MYH7,NOTCH1,RYR2,TPM1,UBE4B	VertebrateAncestor	33.9362
GO.Biological.Process	GO:1904375	regulation.of.protein.localization.to.cell.periphery	341	1.007615e-38	1.301536e-34	3.816822e-37	3.981258e+0	LRP1,SPTBN1	VertebrateAncestor	33.8855
GO.Biological.Process	GO:0007274	neuromuscular.synaptic.transmission	342	1.260319e-38	1.627954e-34	4.760100e-37	1.081963e+1	KIF1B	VertebrateAncestor	33.7884
GO.Biological.Process	GO:0044782	cilium.organization	343	1.430072e-38	1.847224e-34	5.385493e-37	2.672427e+0	BBS7,CELSR3,CKAP5,DNAH5,DNAH6,DNAH7,DNHD1,DYNC1H1,FLNA,GALNT11,HSP90AA1,LAMA5,NOTCH1,RILP,TTC21B	VertebrateAncestor	33.7335
GO.Biological.Process	GO:0006526	arginine.biosynthetic.process	344	1.579194e-38	2.039845e-34	5.929782e-37	2.122976e+1	ASS1,CAD	VertebrateAncestor	33.6904
GO.Biological.Process	GO:0007185	transmembrane.receptor.protein.tyrosine.phosphatase.signaling.pathway	345	1.687185e-38	2.179337e-34	6.316918e-37	1.045876e+1	TRIO	VertebrateAncestor	33.6617
GO.Biological.Process	GO:1902808	positive.regulation.of.cell.cycle.G1/S.phase.transition	346	1.743211e-38	2.251706e-34	6.507820e-37	7.064409e+0	RPTOR	VertebrateAncestor	33.6475
GO.Biological.Process	GO:0010644	cell.communication.by.electrical.coupling	347	1.808020e-38	2.335419e-34	6.730315e-37	8.569682e+0	ATP1A3,RYR2	VertebrateAncestor	33.6316
GO.Biological.Process	GO:0051654	establishment.of.mitochondrion.localization	348	2.533575e-38	3.272619e-34	9.404077e-37	1.067499e+1	KIF1B	VertebrateAncestor	33.4851
GO.Biological.Process	GO:0051592	response.to.calcium.ion	349	2.743363e-38	3.543602e-34	1.015359e-36	3.544209e+0	ITPR3,RYR1,RYR2,RYR3,TRPC3,TTN	VertebrateAncestor	33.4506
GO.Biological.Process	GO:0043618	regulation.of.transcription.from.RNA.polymerase.II.promoter.in.response.to.stress	350	1.321706e-37	1.707248e-33	4.877850e-36	4.756297e+0	CA9,CREBBP,NOTCH1,PSME4	VertebrateAncestor	32.7677
GO.Biological.Process	GO:1905477	positive.regulation.of.protein.localization.to.membrane	351	2.174397e-37	2.808669e-33	8.001905e-36	3.695962e+0	LRP1,LRP4,SPTBN1	VertebrateAncestor	32.5515
GO.Biological.Process	GO:1901894	regulation.of.calcium-transporting.ATPase.activity	352	5.079515e-37	6.561210e-33	1.863980e-35	1.300433e+1	RYR2	VertebrateAncestor	32.183
GO.Biological.Process	GO:0014902	myotube.differentiation	353	5.521526e-37	7.132155e-33	2.020441e-35	4.812407e+0	MYH9,MYOF,RYR1	VertebrateAncestor	32.1468
GO.Biological.Process	GO:0010800	positive.regulation.of.peptidyl-threonine.phosphorylation	354	5.994740e-37	7.743406e-33	2.187403e-35	6.692054e+0	RPTOR	VertebrateAncestor	32.1111
GO.Biological.Process	GO:0070286	axonemal.dynein.complex.assembly	355	1.011034e-36	1.305953e-32	3.678740e-35	9.673368e+0	DNAH5,DNAH7,DNHD1	VertebrateAncestor	31.8841
GO.Biological.Process	GO:0002097	tRNA.wobble.base.modification	356	2.091368e-36	2.701420e-32	7.588259e-35	1.474030e+1	TRMU	VertebrateAncestor	31.5684
GO.Biological.Process	GO:0006325	chromatin.organization	357	4.541089e-36	5.865725e-32	1.643060e-34	1.982321e+0	APBB1,CENPS,CREBBP,ESR1,HUWE1,KMT2C,KMT2D,PSME4,RIF1,RRP8,SETD2,SETD6,SMARCA5,TAF10,TRRAP,TSPYL6,USP15	VertebrateAncestor	31.2317
GO.Biological.Process	GO:0048511	rhythmic.process	358	4.563508e-36	5.894683e-32	1.646560e-34	2.372042e+0	CREBBP,ESR1,FBXL3,MTNR1A,ZFHX3	VertebrateAncestor	31.2295
GO.Biological.Process	GO:0006857	oligopeptide.transport	359	9.019104e-36	1.164998e-31	3.245119e-34	1.796589e+1	ABCC1	VertebrateAncestor	30.9337
GO.Biological.Process	GO:0051284	positive.regulation.of.sequestering.of.calcium.ion	360	1.178037e-35	1.521670e-31	4.226862e-34	1.213125e+1	RYR2	VertebrateAncestor	30.8177
GO.Biological.Process	GO:0060402	calcium.ion.transport.into.cytosol	361	1.215611e-35	1.570205e-31	4.349598e-34	4.240959e+0	ITPR3,RYR1,RYR2,RYR3	VertebrateAncestor	30.804
GO.Biological.Process	GO:0042059	negative.regulation.of.epidermal.growth.factor.receptor.signaling.pathway	362	1.288208e-35	1.663978e-31	4.596625e-34	5.458519e+0	CHMP6	VertebrateAncestor	30.7789
GO.Biological.Process	GO:1903729	regulation.of.plasma.membrane.organization	363	1.555360e-35	2.009059e-31	5.534596e-34	3.694504e+0	LRP1,SPTBN1	VertebrateAncestor	30.697
GO.Biological.Process	GO:0006606	protein.import.into.nucleus	364	1.597078e-35	2.062946e-31	5.667433e-34	3.427686e+0	IPO7,NCKIPSD,SPTBN1	VertebrateAncestor	30.6855
GO.Biological.Process	GO:0016266	O-glycan.processing	365	2.231765e-35	2.882771e-31	7.898002e-34	4.782786e+0	GALNT11,GALNT3,MUC5AC,MUC5B,MUC6	VertebrateAncestor	30.5402
GO.Biological.Process	GO:0030644	cellular.chloride.ion.homeostasis	366	2.268169e-35	2.929794e-31	8.004901e-34	2.913999e+1	CKB	VertebrateAncestor	30.5332
GO.Biological.Process	GO:0098735	positive.regulation.of.the.force.of.heart.contraction	367	2.473470e-35	3.194981e-31	8.705671e-34	1.193323e+1	RYR2	VertebrateAncestor	30.4955
GO.Biological.Process	GO:0051345	positive.regulation.of.hydrolase.activity	368	2.716916e-35	3.509440e-31	9.536523e-34	1.850389e+0	ADRM1,AHSA2,CCL25,DNAJC10,EIF5,ESR1,HSPD1,HSPE1,PSME4,RYR2,SCRIB,SLC39A10,TPM1	VertebrateAncestor	30.4548
GO.Biological.Process	GO:0032481	positive.regulation.of.type.I.interferon.production	369	3.612618e-35	4.666419e-31	1.264612e-33	5.380383e+0	CREBBP,HSPD1,SETD2	VertebrateAncestor	30.331
GO.Biological.Process	GO:0006720	isoprenoid.metabolic.process	370	5.439665e-35	7.026415e-31	1.899031e-33	3.841425e+0	CYP26A1,CYP26C1,DHRS9,LRP1,LRP2	VertebrateAncestor	30.1533
GO.Biological.Process	GO:0035036	sperm-egg.recognition	371	6.404978e-35	8.273310e-31	2.230003e-33	7.296238e+0	ACR,ZP4	VertebrateAncestor	30.0823
GO.Biological.Process	GO:0006657	CDP-choline.pathway	372	6.519256e-35	8.420923e-31	2.263689e-33	2.432575e+1	CDS1,CHKB	VertebrateAncestor	30.0746
GO.Biological.Process	GO:0071230	cellular.response.to.amino.acid.stimulus	373	7.083390e-35	9.149615e-31	2.452980e-33	4.295042e+0	BAIAP2,RPTOR	VertebrateAncestor	30.0386
GO.Biological.Process	GO:0018243	protein.O-linked.glycosylation.via.threonine	374	7.274828e-35	9.396895e-31	2.512539e-33	9.143728e+0	GALNT11,GALNT3	VertebrateAncestor	30.027
GO.Biological.Process	GO:0060119	inner.ear.receptor.cell.development	375	7.326537e-35	9.463688e-31	2.523650e-33	5.687167e+0	CDH23,FAT4,MYO7A,SCRIB	VertebrateAncestor	30.0239
GO.Biological.Process	GO:0060065	uterus.development	376	1.532771e-34	1.979880e-30	5.265639e-33	6.918706e+0	ESR1	VertebrateAncestor	29.7034
GO.Biological.Process	GO:2000344	positive.regulation.of.acrosome.reaction	377	2.551732e-34	3.296072e-30	8.742897e-33	1.132929e+1	ZP4	VertebrateAncestor	29.482
GO.Biological.Process	GO:2000378	negative.regulation.of.reactive.oxygen.species.metabolic.process	378	2.606014e-34	3.366188e-30	8.905260e-33	6.614745e+0	AATF,TRAP1	VertebrateAncestor	29.4729
GO.Biological.Process	GO:1903522	regulation.of.blood.circulation	379	3.751313e-34	4.845571e-30	1.278515e-32	2.279467e+0	ATP1A3,FLNA,FOXN4,ITPR3,MYH6,MYH7,RYR1,RYR2,RYR3,TPM1,UCN	VertebrateAncestor	29.3147
GO.Biological.Process	GO:0048839	inner.ear.development	380	3.819662e-34	4.933857e-30	1.298384e-32	2.441371e+0	CDH23,CELSR1,DCHS1,FAT4,FREM2,FRZB,MYO7A,NOTCH1,SCRIB	VertebrateAncestor	29.3068
GO.Biological.Process	GO:0035567	non-canonical.Wnt.signaling.pathway	381	5.511290e-34	7.118933e-30	1.868486e-32	3.295007e+0	CELSR1,CELSR2,CELSR3,FRZB,PSME4,SMURF1	VertebrateAncestor	29.1476
GO.Biological.Process	GO:0051170	nuclear.import	382	9.662530e-34	1.248109e-29	3.267301e-32	3.182434e+0	IPO7,NCKIPSD,PRKAG1,SPTBN1	VertebrateAncestor	28.9037
GO.Biological.Process	GO:0051480	regulation.of.cytosolic.calcium.ion.concentration	383	1.477394e-33	1.908350e-29	4.982637e-32	2.527045e+0	CDH23,ESR1,F2,ITPR3,RYR1,RYR2,RYR3	VertebrateAncestor	28.7193
GO.Biological.Process	GO:2000601	positive.regulation.of.Arp2/3.complex-mediated.actin.nucleation	384	1.625137e-33	2.099189e-29	5.466639e-32	2.360036e+1	NCKAP1	VertebrateAncestor	28.6779
GO.Biological.Process	GO:0072337	modified.amino.acid.transport	385	1.844360e-33	2.382360e-29	6.187948e-32	9.043392e+0	ABCC1,LRP2	VertebrateAncestor	28.623
GO.Biological.Process	GO:0070838	divalent.metal.ion.transport	386	2.005437e-33	2.590423e-29	6.710940e-32	2.391481e+0	CDH23,DENND5A,ITPR3,RYR1,RYR2,RYR3,SLC30A3,SLC39A10,SPG7,TRPC3,TRPC4AP	VertebrateAncestor	28.5866
GO.Biological.Process	GO:0045104	intermediate.filament.cytoskeleton.organization	387	2.441461e-33	3.153635e-29	8.148928e-32	6.485922e+0	DST,EPPK1,FAM83H	VertebrateAncestor	28.5012
GO.Biological.Process	GO:1901856	negative.regulation.of.cellular.respiration	388	2.739077e-33	3.538066e-29	9.118726e-32	1.622607e+1	TRAP1	VertebrateAncestor	28.4512
GO.Biological.Process	GO:0051303	establishment.of.chromosome.localization	389	2.975530e-33	3.843492e-29	9.880442e-32	4.828648e+0	CHMP6,PSRC1	VertebrateAncestor	28.4153
GO.Biological.Process	GO:0043620	regulation.of.DNA-templated.transcription.in.response.to.stress	390	3.396163e-33	4.386824e-29	1.124827e-31	4.204763e+0	CA9,CREBBP,NOTCH1,PSME4	VertebrateAncestor	28.3578
GO.Biological.Process	GO:0045103	intermediate.filament-based.process	391	3.969785e-33	5.127771e-29	1.311450e-31	6.433183e+0	DST,EPPK1,FAM83H	VertebrateAncestor	28.2901
GO.Biological.Process	GO:0072511	divalent.inorganic.cation.transport	392	4.555074e-33	5.883789e-29	1.500967e-31	2.377832e+0	CDH23,DENND5A,ITPR3,RYR1,RYR2,RYR3,SLC30A3,SLC39A10,SPG7,TRPC3,TRPC4AP	VertebrateAncestor	28.2303
GO.Biological.Process	GO:0050000	chromosome.localization	393	5.065412e-33	6.542993e-29	1.664884e-31	4.793473e+0	CHMP6,PSRC1	VertebrateAncestor	28.1842
GO.Biological.Process	GO:0002009	morphogenesis.of.an.epithelium	394	5.868213e-33	7.579971e-29	1.923850e-31	1.947579e+0	BBS7,CA9,CELSR1,DCHS1,ESR1,FAT4,FLNA,FOXN4,FREM2,FRZB,ILK,LAMA5,LRP2,NOTCH1,RYR2,SCRIB,SETD2	VertebrateAncestor	28.1203
GO.Biological.Process	GO:0006739	NADP.metabolic.process	395	9.160935e-33	1.183318e-28	2.995742e-31	7.918179e+0	PGD,RPE	VertebrateAncestor	27.9269
GO.Biological.Process	GO:0051289	protein.homotetramerization	396	9.581616e-33	1.237657e-28	3.125397e-31	4.804278e+0	ACACB,ACTN2,RYR1,RYR3,SHMT2	VertebrateAncestor	27.9074
GO.Biological.Process	GO:0055064	chloride.ion.homeostasis	397	1.019450e-32	1.316824e-28	3.316936e-31	2.390347e+1	CKB	VertebrateAncestor	27.8805
GO.Biological.Process	GO:0071108	protein.K48-linked.deubiquitination	398	1.085780e-32	1.402502e-28	3.523874e-31	8.082566e+0	USP34	VertebrateAncestor	27.8531
GO.Biological.Process	GO:0060088	auditory.receptor.cell.stereocilium.organization	399	1.728697e-32	2.232958e-28	5.596386e-31	1.924369e+1	MYO7A,SCRIB	VertebrateAncestor	27.6511
GO.Biological.Process	GO:0071286	cellular.response.to.magnesium.ion	400	2.176010e-32	2.810752e-28	7.026880e-31	1.613517e+1	RYR3	VertebrateAncestor	27.5512
GO.Biological.Process	GO:0099133	ATP.hydrolysis.coupled.anion.transmembrane.transport	401	3.938207e-32	5.086982e-28	1.268574e-30	1.313803e+1	ABCC1,ABCC6	VertebrateAncestor	27.2935
GO.Biological.Process	GO:1904808	positive.regulation.of.protein.oxidation	402	4.739268e-32	6.121712e-28	1.522814e-30	2.447539e+1	TRABD2A	VertebrateAncestor	27.2131
GO.Biological.Process	GO:0034315	regulation.of.Arp2/3.complex-mediated.actin.nucleation	403	9.249060e-32	1.194701e-27	2.964519e-30	1.549403e+1	ARFIP2,NCKAP1	VertebrateAncestor	26.9227
GO.Biological.Process	GO:0002920	regulation.of.humoral.immune.response	404	1.077238e-31	1.391468e-27	3.444229e-30	6.657143e+0	F2,HPX,ZP4	VertebrateAncestor	26.8565
GO.Biological.Process	GO:0006816	calcium.ion.transport	405	1.204004e-31	1.555212e-27	3.840030e-30	2.457379e+0	CDH23,DENND5A,ITPR3,RYR1,RYR2,RYR3,SPG7,TRPC3,TRPC4AP	VertebrateAncestor	26.8082
GO.Biological.Process	GO:0001894	tissue.homeostasis	406	1.254908e-31	1.620965e-27	3.992524e-30	3.023993e+0	ADGRV1,ANKRD11,CDH23,MUC6,TPP1	VertebrateAncestor	26.7902
GO.Biological.Process	GO:0060325	face.morphogenesis	407	1.275836e-31	1.647997e-27	4.049134e-30	5.690388e+0	ANKRD11	VertebrateAncestor	26.783
GO.Biological.Process	GO:0060401	cytosolic.calcium.ion.transport	408	1.414323e-31	1.826881e-27	4.477650e-30	3.799368e+0	ITPR3,RYR1,RYR2,RYR3	VertebrateAncestor	26.7383
GO.Biological.Process	GO:1905516	positive.regulation.of.fertilization	409	1.669574e-31	2.156589e-27	5.272833e-30	9.793555e+0	ZP4	VertebrateAncestor	26.6662
GO.Biological.Process	GO:0000959	mitochondrial.RNA.metabolic.process	410	1.835203e-31	2.370532e-27	5.781785e-30	8.681309e+0	HSD17B10,TRMU	VertebrateAncestor	26.6252
GO.Biological.Process	GO:1903919	negative.regulation.of.actin.filament.severing	411	2.187821e-31	2.826008e-27	6.875933e-30	8.097581e+1	MYH9	VertebrateAncestor	26.5488
GO.Biological.Process	GO:0001701	in.utero.embryonic.development	412	2.895666e-31	3.740332e-27	9.078475e-30	2.227342e+0	ANKRD11,BIRC6,MYH6,MYH9,NOTCH1,SETD2,TPM1	VertebrateAncestor	26.4271
GO.Biological.Process	GO:0060444	branching.involved.in.mammary.gland.duct.morphogenesis	413	3.268165e-31	4.221489e-27	1.022152e-29	6.072007e+0	ESR1	VertebrateAncestor	26.3745
GO.Biological.Process	GO:1901299	negative.regulation.of.hydrogen.peroxide-mediated.programmed.cell.death	414	3.459609e-31	4.468777e-27	1.079415e-29	1.421289e+1	TRAP1	VertebrateAncestor	26.3498
GO.Biological.Process	GO:0002077	acrosome.matrix.dispersal	415	8.120277e-31	1.048896e-26	2.527461e-29	1.106572e+2	ACR	VertebrateAncestor	25.9793
GO.Biological.Process	GO:0000050	urea.cycle	416	8.551813e-31	1.104638e-26	2.655379e-29	1.323449e+1	ASS1,CAD	VertebrateAncestor	25.9568
GO.Biological.Process	GO:0050715	positive.regulation.of.cytokine.secretion	417	8.656280e-31	1.118132e-26	2.681371e-29	3.664585e+0	SPTBN1	VertebrateAncestor	25.9515
GO.Biological.Process	GO:0034728	nucleosome.organization	418	8.694732e-31	1.123099e-26	2.686839e-29	3.541410e+0	CENPS,PSME4,SETD2,SMARCA5,TSPYL6	VertebrateAncestor	25.9496
GO.Biological.Process	GO:0060749	mammary.gland.alveolus.development	419	1.263328e-30	1.631841e-26	3.894608e-29	5.931858e+0	ESR1	VertebrateAncestor	25.7873
GO.Biological.Process	GO:0006914	autophagy	420	1.335602e-30	1.725197e-26	4.107612e-29	2.917808e+0	CHMP6,HSP90AA1,PRKAG1,SMURF1,TOLLIP,WDFY3	VertebrateAncestor	25.7632
GO.Biological.Process	GO:0035331	negative.regulation.of.hippo.signaling	421	1.673580e-30	2.161763e-26	5.134830e-29	1.428178e+1	MARK3	VertebrateAncestor	25.6652
GO.Biological.Process	GO:0070588	calcium.ion.transmembrane.transport	422	1.678100e-30	2.167602e-26	5.136497e-29	2.670960e+0	DENND5A,ITPR3,RYR1,RYR2,RYR3,TRPC3,TRPC4AP	VertebrateAncestor	25.664
GO.Biological.Process	GO:0014074	response.to.purine-containing.compound	423	1.809907e-30	2.337857e-26	5.526848e-29	3.179826e+0	RYR1,RYR2,RYR3,SLC26A6,TRPC3	VertebrateAncestor	25.6312
GO.Biological.Process	GO:0014706	striated.muscle.tissue.development	424	1.962559e-30	2.535037e-26	5.978862e-29	2.174504e+0	ACTN2,LRP2,MYH6,MYH7,MYOM2,NOTCH1,RYR1,RYR2,SGCG,TPM1,TTN,UBE4B	VertebrateAncestor	25.596
GO.Biological.Process	GO:2000144	positive.regulation.of.DNA-templated.transcription,.initiation	425	2.284848e-30	2.951338e-26	6.944325e-29	5.871267e+0	ESR1	VertebrateAncestor	25.53
GO.Biological.Process	GO:0070509	calcium.ion.import	426	2.910792e-30	3.759870e-26	8.825986e-29	3.663587e+0	ITPR3,RYR1,RYR2,RYR3	VertebrateAncestor	25.4248
GO.Biological.Process	GO:0007605	sensory.perception.of.sound	427	2.978170e-30	3.846902e-26	9.009139e-29	2.751915e+0	ADGRV1,CDH23,LRP2,MYO7A,PGAP1,UCN	VertebrateAncestor	25.4149
GO.Biological.Process	GO:0043433	negative.regulation.of.sequence-specific.DNA.binding.transcription.factor.activity	428	4.397646e-30	5.680439e-26	1.327205e-28	3.014186e+0	ESR1,FLNA,OTULIN,SETD6	VertebrateAncestor	25.2456
GO.Biological.Process	GO:0060046	regulation.of.acrosome.reaction	429	4.496103e-30	5.807616e-26	1.353757e-28	9.087147e+0	ZP4	VertebrateAncestor	25.236
GO.Biological.Process	GO:0045176	apical.protein.localization	430	4.505170e-30	5.819328e-26	1.353332e-28	1.001380e+1	CELSR1	VertebrateAncestor	25.2351
GO.Biological.Process	GO:0006909	phagocytosis	431	4.869094e-30	6.289409e-26	1.459260e-28	2.931051e+0	BAIAP2,HSP90AA1,LRP1,MYH2,MYH9,MYO7A,NCKAP1,NCKIPSD	VertebrateAncestor	25.2014
GO.Biological.Process	GO:0010863	positive.regulation.of.phospholipase.C.activity	432	5.922547e-30	7.650154e-26	1.770869e-28	5.774915e+0	ESR1	VertebrateAncestor	25.1163
GO.Biological.Process	GO:0006937	regulation.of.muscle.contraction	433	6.578428e-30	8.497355e-26	1.962438e-28	2.684077e+0	FLNA,MYH7,RYR2,TPM1,UCN	VertebrateAncestor	25.0707
GO.Biological.Process	GO:1903426	regulation.of.reactive.oxygen.species.biosynthetic.process	434	7.855417e-30	1.014684e-25	2.337982e-28	4.417359e+0	ASS1,HSP90AA1,TRAP1	VertebrateAncestor	24.9937
GO.Biological.Process	GO:0030011	maintenance.of.cell.polarity	435	8.462863e-30	1.093148e-25	2.512984e-28	8.216880e+0	DST	VertebrateAncestor	24.9613
GO.Biological.Process	GO:0008589	regulation.of.smoothened.signaling.pathway	436	9.587374e-30	1.238401e-25	2.840369e-28	3.585550e+0	CREBBP,TTC21B	VertebrateAncestor	24.9071
GO.Biological.Process	GO:0098911	regulation.of.ventricular.cardiac.muscle.cell.action.potential	437	1.442889e-29	1.863780e-25	4.264942e-28	8.848049e+0	RYR2	VertebrateAncestor	24.7296
GO.Biological.Process	GO:0000070	mitotic.sister.chromatid.segregation	438	1.463583e-29	1.890510e-25	4.316233e-28	3.910990e+0	CHMP6,PSRC1,TTN	VertebrateAncestor	24.7234
GO.Biological.Process	GO:0032845	negative.regulation.of.homeostatic.process	439	1.649367e-29	2.130487e-25	4.853046e-28	3.106290e+0	ARRDC3,ITPR3,RYR1,RYR2,RYR3	VertebrateAncestor	24.6715
GO.Biological.Process	GO:0051492	regulation.of.stress.fiber.assembly	440	1.924311e-29	2.485633e-25	5.649165e-28	3.686149e+0	TPM1	VertebrateAncestor	24.6046
GO.Biological.Process	GO:0032796	uropod.organization	441	2.339986e-29	3.022560e-25	6.853877e-28	6.390577e+1	MYH9	VertebrateAncestor	24.5196
GO.Biological.Process	GO:0001696	gastric.acid.secretion	442	3.175773e-29	4.102146e-25	9.280873e-28	1.314029e+1	CHRM5	VertebrateAncestor	24.387
GO.Biological.Process	GO:0016125	sterol.metabolic.process	443	3.255159e-29	4.204689e-25	9.491397e-28	3.582697e+0	APOL1,CYP26A1,CYP26C1	VertebrateAncestor	24.3763
GO.Biological.Process	GO:0033146	regulation.of.intracellular.estrogen.receptor.signaling.pathway	444	3.994133e-29	5.159222e-25	1.161987e-27	4.720864e+0	CNOT1,ESR1,KMT2D	VertebrateAncestor	24.2874
GO.Biological.Process	GO:0019627	urea.metabolic.process	445	4.006689e-29	5.175440e-25	1.163020e-27	1.192537e+1	ASS1,CAD	VertebrateAncestor	24.2861
GO.Biological.Process	GO:0044242	cellular.lipid.catabolic.process	446	4.217185e-29	5.447338e-25	1.221376e-27	3.208817e+0	CPT1B,CYP26A1,CYP26C1,PEX2,PLA2G4B,SMPD1	VertebrateAncestor	24.2638
GO.Biological.Process	GO:0071941	nitrogen.cycle.metabolic.process	447	5.563497e-29	7.186369e-25	1.607689e-27	1.181935e+1	ASS1,CAD	VertebrateAncestor	24.1435
GO.Biological.Process	GO:0000052	citrulline.metabolic.process	448	8.392285e-29	1.084031e-24	2.419713e-27	1.410828e+1	ASS1	VertebrateAncestor	23.965
GO.Biological.Process	GO:0072359	circulatory.system.development	449	1.089418e-28	1.407201e-24	3.134078e-27	1.605938e+0	ACTN2,BBS7,DCHS1,DNAH5,FAT4,FOXN4,FREM2,GALNT11,ILK,LAMA5,LRP1,LRP2,MYH6,MYH7,MYH9,NOTCH1,OTULIN,RYR1,RYR2,SETD2,SGCG,TNFAIP2,TPM1,TTN,UBE4B	VertebrateAncestor	23.8516
GO.Biological.Process	GO:0000819	sister.chromatid.segregation	450	1.283906e-28	1.658421e-24	3.685381e-27	2.980225e+0	CENPS,CHMP6,CKAP5,DYNC1H1,PSRC1,TTN,XPO1	VertebrateAncestor	23.7803
GO.Biological.Process	GO:0035584	calcium-mediated.signaling.using.intracellular.calcium.source	451	1.422169e-28	1.837016e-24	4.073206e-27	8.394838e+0	RYR2	VertebrateAncestor	23.7359
GO.Biological.Process	GO:0071499	cellular.response.to.laminar.fluid.shear.stress	452	1.431472e-28	1.849032e-24	4.090780e-27	1.388537e+1	ASS1	VertebrateAncestor	23.7331
GO.Biological.Process	GO:0048863	stem.cell.differentiation	453	1.666902e-28	2.153137e-24	4.753063e-27	2.465900e+0	CYP26C1,ESR1,FRZB,LAMA5,NOTCH1,SETD2,SETD6	VertebrateAncestor	23.6669
GO.Biological.Process	GO:0030947	regulation.of.vascular.endothelial.growth.factor.receptor.signaling.pathway	454	2.609532e-28	3.370732e-24	7.424521e-27	5.987639e+0	MYOF	VertebrateAncestor	23.4723
GO.Biological.Process	GO:0042908	xenobiotic.transport	455	2.813948e-28	3.634777e-24	7.988520e-27	1.130827e+1	ABCC1	VertebrateAncestor	23.4395
GO.Biological.Process	GO:0051276	chromosome.organization	456	3.124391e-28	4.035776e-24	8.850386e-27	2.075820e+0	CENPS,CHMP6,CKAP5,DYNC1H1,HSP90AA1,PSME4,PSRC1,RIF1,SMARCA5,TSPYL6,TTN,XPO1	VertebrateAncestor	23.3941
GO.Biological.Process	GO:1902176	negative.regulation.of.oxidative.stress-induced.intrinsic.apoptotic.signaling.pathway	457	3.194429e-28	4.126244e-24	9.028980e-27	1.126914e+1	BAG5,TRAP1	VertebrateAncestor	23.3844
GO.Biological.Process	GO:0007204	positive.regulation.of.cytosolic.calcium.ion.concentration	458	3.451769e-28	4.458650e-24	9.735044e-27	2.523938e+0	ESR1,ITPR3,RYR1,RYR2,RYR3	VertebrateAncestor	23.3508
GO.Biological.Process	GO:0060323	head.morphogenesis	459	3.897911e-28	5.034932e-24	1.096935e-26	4.984405e+0	ANKRD11	VertebrateAncestor	23.298
GO.Biological.Process	GO:0034502	protein.localization.to.chromosome	460	3.944810e-28	5.095511e-24	1.107720e-26	5.365023e+0	ESR1	VertebrateAncestor	23.2928
GO.Biological.Process	GO:0007602	phototransduction	461	5.786322e-28	7.474192e-24	1.621300e-26	6.246444e+0	CDS1,TRPC3	VertebrateAncestor	23.1264
GO.Biological.Process	GO:1900274	regulation.of.phospholipase.C.activity	462	6.184505e-28	7.988525e-24	1.729118e-26	5.322523e+0	ESR1	VertebrateAncestor	23.0975
GO.Biological.Process	GO:0034121	regulation.of.toll-like.receptor.signaling.pathway	463	7.818815e-28	1.009956e-23	2.181331e-26	5.300463e+0	ESR1	VertebrateAncestor	22.9957
GO.Biological.Process	GO:0007067	mitotic.nuclear.division	464	8.684924e-28	1.121832e-23	2.417741e-26	3.084971e+0	CHMP6,DYNC1H1,FLNA,PSRC1,SETD2,TTN	VertebrateAncestor	22.9501
GO.Biological.Process	GO:0008105	asymmetric.protein.localization	465	8.899543e-28	1.149554e-23	2.472159e-26	8.810136e+0	CELSR1	VertebrateAncestor	22.9395
GO.Biological.Process	GO:0051646	mitochondrion.localization	466	9.780402e-28	1.263335e-23	2.711018e-26	6.579566e+0	KIF1B	VertebrateAncestor	22.8985
GO.Biological.Process	GO:0070423	nucleotide-binding.oligomerization.domain.containing.signaling.pathway	467	1.184798e-27	1.530404e-23	3.277095e-26	6.415204e+0	OTULIN	VertebrateAncestor	22.8152
GO.Biological.Process	GO:0006352	DNA-templated.transcription,.initiation	468	2.058114e-27	2.658466e-23	5.680483e-26	2.563867e+0	CREBBP,ESR1,NOTCH1,SMARCA5,TAF10	VertebrateAncestor	22.5754
GO.Biological.Process	GO:0031334	positive.regulation.of.protein.complex.assembly	469	2.164680e-27	2.796117e-23	5.961870e-26	2.579868e+0	BAIAP2,ESR1,NCKAP1,PSRC1,TRABD2A	VertebrateAncestor	22.5534
GO.Biological.Process	GO:0003205	cardiac.chamber.development	470	3.150568e-27	4.069589e-23	8.658699e-26	2.335547e+0	LRP2,MYH6,MYH7,NOTCH1,RYR2,TPM1,UBE4B	VertebrateAncestor	22.3904
GO.Biological.Process	GO:0035994	response.to.muscle.stretch	471	3.304672e-27	4.268645e-23	9.062940e-26	6.155724e+0	RYR2,TTN	VertebrateAncestor	22.3697
GO.Biological.Process	GO:0006664	glycolipid.metabolic.process	472	3.427345e-27	4.427102e-23	9.379452e-26	3.608777e+0	ARSA,PGAP1,PSAP,SMPD1	VertebrateAncestor	22.3539
GO.Biological.Process	GO:0035872	nucleotide-binding.domain,.leucine.rich.repeat.containing.receptor.signaling.pathway	473	4.344739e-27	5.612099e-23	1.186490e-25	6.247854e+0	OTULIN	VertebrateAncestor	22.2509
GO.Biological.Process	GO:0006323	DNA.packaging	474	4.547677e-27	5.874234e-23	1.239290e-25	3.093495e+0	CENPS,PSME4,SMARCA5,TSPYL6,TTN	VertebrateAncestor	22.231
GO.Biological.Process	GO:0090179	planar.cell.polarity.pathway.involved.in.neural.tube.closure	475	4.592857e-27	5.932593e-23	1.248967e-25	8.463349e+0	CELSR1	VertebrateAncestor	22.2268
GO.Biological.Process	GO:0016573	histone.acetylation	476	5.441922e-27	7.029331e-23	1.476750e-25	3.673010e+0	APBB1,CREBBP,TAF10,TRRAP	VertebrateAncestor	22.1531
GO.Biological.Process	GO:0071872	cellular.response.to.epinephrine.stimulus	477	5.556653e-27	7.177529e-23	1.504723e-25	7.710815e+0	RYR2	VertebrateAncestor	22.144
GO.Biological.Process	GO:0051282	regulation.of.sequestering.of.calcium.ion	478	6.757158e-27	8.728221e-23	1.825988e-25	3.167980e+0	F2,ITPR3,RYR1,RYR2,RYR3	VertebrateAncestor	22.0591
GO.Biological.Process	GO:1903923	positive.regulation.of.protein.processing.in.phagocytic.vesicle	479	8.998440e-27	1.162328e-22	2.426573e-25	4.720838e+1	MYH9	VertebrateAncestor	21.9347
GO.Biological.Process	GO:0009887	animal.organ.morphogenesis	480	1.050670e-26	1.357150e-22	2.827397e-25	1.546862e+0	ANKRD11,BBS7,CELSR1,DCHS1,ESR1,FAT4,FOXN4,FRZB,ILK,LAMA5,LRP2,LRP4,MYH6,MYH7,MYO7A,NOTCH1,RYR1,RYR2,SCRIB,SETD2,TPM1,TTN,UBE4B	VertebrateAncestor	21.8674
GO.Biological.Process	GO:0035973	aggrephagy	481	1.273441e-26	1.644904e-22	3.419758e-25	1.420103e+1	WDFY3	VertebrateAncestor	21.7839
GO.Biological.Process	GO:0009416	response.to.light.stimulus	482	1.295062e-26	1.672832e-22	3.470605e-25	2.374752e+0	ATP1A3,CDS1,CREBBP,FBXL3,TRPC3,UBE4B	VertebrateAncestor	21.7765
GO.Biological.Process	GO:0006600	creatine.metabolic.process	483	1.354503e-26	1.749612e-22	3.622384e-25	1.502479e+1	CKB	VertebrateAncestor	21.7571
GO.Biological.Process	GO:0003214	cardiac.left.ventricle.morphogenesis	484	1.567942e-26	2.025311e-22	4.184526e-25	6.794053e+0	NOTCH1,RYR2	VertebrateAncestor	21.6935
GO.Biological.Process	GO:0043583	ear.development	485	1.779683e-26	2.298817e-22	4.739828e-25	2.145689e+0	CDH23,CELSR1,DCHS1,FAT4,FREM2,FRZB,MYO7A,NOTCH1,SCRIB	VertebrateAncestor	21.6385
GO.Biological.Process	GO:0050954	sensory.perception.of.mechanical.stimulus	486	2.240835e-26	2.894487e-22	5.955734e-25	2.498931e+0	ADGRV1,CDH23,LRP2,MYO7A,PGAP1,SCN1A,UCN	VertebrateAncestor	21.5384
GO.Biological.Process	GO:0044087	regulation.of.cellular.component.biogenesis	487	2.284781e-26	2.951252e-22	6.060065e-25	1.613208e+0	ARFIP2,BAG5,BAIAP2,CNOT1,ESR1,HEATR1,HSP90AA1,MACF1,NCKAP1,NOTCH1,PSRC1,SACS,SPTBN1,SPTBN5,TPM1,TRABD2A	VertebrateAncestor	21.53
GO.Biological.Process	GO:0060285	cilium-dependent.cell.motility	488	2.397604e-26	3.096985e-22	6.346281e-25	6.730847e+0	DNAH17,DNAH7	VertebrateAncestor	21.5091
GO.Biological.Process	GO:0071318	cellular.response.to.ATP	489	2.556819e-26	3.302643e-22	6.753871e-25	1.084991e+1	RYR3	VertebrateAncestor	21.4811
GO.Biological.Process	GO:1901701	cellular.response.to.oxygen-containing.compound	490	2.579605e-26	3.332076e-22	6.800155e-25	1.623990e+0	ACTN2,ADCY9,ATP1A3,ATP6V1F,BAIAP2,CHRM5,ESR1,GRIK5,LRP1,MTR,PRPF8,RPTOR,RYR2,RYR3,SLC26A6,TPM1	VertebrateAncestor	21.4773
GO.Biological.Process	GO:0018393	internal.peptidyl-lysine.acetylation	491	2.683750e-26	3.466600e-22	7.060285e-25	3.593301e+0	APBB1,CREBBP,TAF10,TRRAP	VertebrateAncestor	21.4601
GO.Biological.Process	GO:0019752	carboxylic.acid.metabolic.process	492	3.135453e-26	4.050065e-22	8.231839e-25	1.791681e+0	ABCC1,ACACB,ALDH1L2,ASS1,CAD,CCDC12,CKB,CPT1B,CYP26A1,CYP26C1,DHRS9,FASN,HSD17B10,MTR,PEX2,PGD,PLA2G4B,PRKAG1,SHMT2	VertebrateAncestor	21.3925
GO.Biological.Process	GO:0007200	phospholipase.C-activating.G-protein.coupled.receptor.signaling.pathway	493	3.710780e-26	4.793215e-22	9.722545e-25	2.986719e+0	ACTN2,CHRM5,ESR1	VertebrateAncestor	21.3194
GO.Biological.Process	GO:0032231	regulation.of.actin.filament.bundle.assembly	494	3.810230e-26	4.921674e-22	9.962903e-25	3.345838e+0	TPM1	VertebrateAncestor	21.3079
GO.Biological.Process	GO:1901185	negative.regulation.of.ERBB.signaling.pathway	495	3.870404e-26	4.999401e-22	1.009980e-24	3.976908e+0	CHMP6	VertebrateAncestor	21.3011
GO.Biological.Process	GO:0060537	muscle.tissue.development	496	4.002542e-26	5.170084e-22	1.042356e-24	2.029393e+0	ACTN2,LRP2,MYH6,MYH7,MYOM2,NOTCH1,RYR1,RYR2,SGCG,TPM1,TTN,UBE4B	VertebrateAncestor	21.2865
GO.Biological.Process	GO:1903427	negative.regulation.of.reactive.oxygen.species.biosynthetic.process	497	4.461868e-26	5.763395e-22	1.159637e-24	1.023843e+1	TRAP1	VertebrateAncestor	21.2393
GO.Biological.Process	GO:0038096	Fc-gamma.receptor.signaling.pathway.involved.in.phagocytosis	498	4.508623e-26	5.823788e-22	1.169435e-24	4.048595e+0	BAIAP2,HSP90AA1,MYH2,NCKAP1,NCKIPSD	VertebrateAncestor	21.2348
GO.Biological.Process	GO:0001738	morphogenesis.of.a.polarized.epithelium	499	5.026475e-26	6.492698e-22	1.301142e-24	5.235727e+0	CELSR1,LAMA5	VertebrateAncestor	21.1876
GO.Biological.Process	GO:0046339	diacylglycerol.metabolic.process	500	5.615637e-26	7.253718e-22	1.450744e-24	1.281984e+1	PGS1	VertebrateAncestor	21.1394
#.GO.Biological.Process	12917	1	1000	VertebrateAncestor	inf