GO.Biological.Process	GO:0090026	positive.regulation.of.monocyte.chemotaxis	1	2.000421e-240	2.583944e-236	2.583944e-236	1.091509e+1	CXCL12,CXCL17,FPR2,SERPINE1,TNFSF18	MammalianAncestor	235.588
GO.Biological.Process	GO:1990478	response.to.ultrasound	2	3.691956e-236	4.768900e-232	2.384450e-232	2.737425e+1	CXCL12	MammalianAncestor	231.322
GO.Biological.Process	GO:1903237	negative.regulation.of.leukocyte.tethering.or.rolling	3	4.693961e-227	6.063189e-223	2.021063e-223	2.254400e+1	CCL25,CXCL12	MammalianAncestor	222.217
GO.Biological.Process	GO:0071677	positive.regulation.of.mononuclear.cell.migration	4	1.512167e-209	1.953266e-205	4.883165e-206	8.805977e+0	CXCL12,CXCL17,FPR2,SERPINE1,TNFSF18	MammalianAncestor	204.709
GO.Biological.Process	GO:1903236	regulation.of.leukocyte.tethering.or.rolling	5	5.525085e-186	7.136752e-182	1.427350e-182	1.483673e+1	CCL25,CXCL12	MammalianAncestor	181.146
GO.Biological.Process	GO:0090025	regulation.of.monocyte.chemotaxis	6	3.106646e-178	4.012855e-174	6.688091e-175	7.039723e+0	CXCL12,CXCL17,FPR2,SERPINE1,TNFSF18	MammalianAncestor	173.397
GO.Biological.Process	GO:1903038	negative.regulation.of.leukocyte.cell-cell.adhesion	7	1.694617e-172	2.188937e-168	3.127053e-169	3.499107e+0	BTN2A2,CCL25,CEACAM1,CXCL12,DLG1,DTX1,DUSP22,FCGR2B,HLA-G,IL20RB,IL2RA,IL4R,LILRB2,NFKBID,PRNP,SCGB1A1,SFTPD,SPN,TARM1,TNFSF18,TNFSF4	MammalianAncestor	167.66
GO.Biological.Process	GO:1904995	negative.regulation.of.leukocyte.adhesion.to.vascular.endothelial.cell	8	7.456746e-172	9.631879e-168	1.203985e-168	1.281347e+1	CCL25,CXCL12	MammalianAncestor	167.016
GO.Biological.Process	GO:2001256	regulation.of.store-operated.calcium.entry	9	2.072245e-161	2.676719e-157	2.974132e-158	1.445845e+1	CD84,SARAF	MammalianAncestor	156.572
GO.Biological.Process	GO:0002820	negative.regulation.of.adaptive.immune.response	10	8.103475e-147	1.046726e-142	1.046726e-143	5.643737e+0	ALOX15,CEACAM1,DUSP22,FCGR2B,IL20RB,IL4R,SLAMF1,SPN,TNFSF18,TNFSF4,TRIM27	MammalianAncestor	141.98
GO.Biological.Process	GO:0050906	detection.of.stimulus.involved.in.sensory.perception	11	1.262044e-143	1.630182e-139	1.481984e-140	2.593305e+0	AZGP1,CST1,CST2,CST4,CXCL12,ENSG00000182974,OR10H1,OR10H2,OR10H3,OR10H4,OR10H5,OR10J1,OR10J3,OR10J5,OR10T2,OR13A1,OR13D1,OR13F1,OR13H1,OR14I1,OR1M1,OR2A1,OR2AE1,OR2B11,OR2C3,OR2F2,OR2G2,OR2H2,OR2K2,OR2V1,OR2V2,OR2W1,OR2Y1,OR4C12,OR4E2,OR4F15,OR4F16,OR4F17,OR4F29,OR4F4,OR4F5,OR4F6,OR4N4,OR6B2,OR6B3,OR6K2,OR6K3,OR6K6,OR6N1,OR6N2,OR6S1,OR9A4,RTP3,RTP5,TAS2R3,TAS2R38,TAS2R4,TAS2R5,TMC2	MammalianAncestor	138.788
GO.Biological.Process	GO:0033603	positive.regulation.of.dopamine.secretion	12	1.571334e-134	2.029692e-130	1.691410e-131	9.174019e+0	CXCL12	MammalianAncestor	129.693
GO.Biological.Process	GO:0022408	negative.regulation.of.cell-cell.adhesion	13	1.604578e-129	2.072633e-125	1.594333e-126	2.705157e+0	ALOX12,BTN2A2,CCL25,CEACAM1,CXCL12,DLG1,DTX1,DUSP22,EPB41L5,FCGR2B,HLA-G,IL20RB,IL2RA,IL4R,LILRB2,MAPK7,MUC21,MYADM,NFKBID,PRNP,SCGB1A1,SFTPD,SPINT2,SPN,TARM1,TNFSF18,TNFSF4	MammalianAncestor	124.683
GO.Biological.Process	GO:0050907	detection.of.chemical.stimulus.involved.in.sensory.perception	14	1.693318e-129	2.187259e-125	1.562328e-126	2.930794e+0	AZGP1,CST1,CST2,CST4,ENSG00000182974,OR10H1,OR10H2,OR10H3,OR10H4,OR10H5,OR10J1,OR10J3,OR10J5,OR10T2,OR13A1,OR13D1,OR13F1,OR13H1,OR14I1,OR1M1,OR2A1,OR2AE1,OR2B11,OR2C3,OR2F2,OR2G2,OR2H2,OR2K2,OR2V1,OR2V2,OR2W1,OR2Y1,OR4C12,OR4E2,OR4F15,OR4F16,OR4F17,OR4F29,OR4F4,OR4F5,OR4F6,OR4N4,OR6B2,OR6B3,OR6K2,OR6K3,OR6K6,OR6N1,OR6N2,OR6S1,OR9A4,RTP3,RTP5,TAS2R3,TAS2R38,TAS2R4,TAS2R5	MammalianAncestor	124.66
GO.Biological.Process	GO:0002692	negative.regulation.of.cellular.extravasation	15	8.043386e-128	1.038964e-123	6.926428e-125	8.005510e+0	CCL25,CXCL12	MammalianAncestor	122.983
GO.Biological.Process	GO:1904994	regulation.of.leukocyte.adhesion.to.vascular.endothelial.cell	16	3.731840e-122	4.820418e-118	3.012761e-119	7.520265e+0	CCL25,CXCL12	MammalianAncestor	117.317
GO.Biological.Process	GO:0044342	type.B.pancreatic.cell.proliferation	17	2.774793e-121	3.584200e-117	2.108353e-118	9.681286e+0	IGFBP3	MammalianAncestor	116.446
GO.Biological.Process	GO:0071675	regulation.of.mononuclear.cell.migration	18	1.412761e-120	1.824863e-116	1.013813e-117	4.316826e+0	CXCL12,CXCL17,FPR2,SERPINE1,SLAMF1,TNFSF18	MammalianAncestor	115.739
GO.Biological.Process	GO:0035970	peptidyl-threonine.dephosphorylation	19	1.556653e-120	2.010729e-116	1.058278e-117	7.511275e+0	DUSP1,DUSP4	MammalianAncestor	115.697
GO.Biological.Process	GO:0050966	detection.of.mechanical.stimulus.involved.in.sensory.perception.of.pain	20	7.666987e-117	9.903447e-113	4.951724e-114	7.497029e+0	CXCL12	MammalianAncestor	112.004
GO.Biological.Process	GO:0051205	protein.insertion.into.membrane	21	1.076427e-116	1.390421e-112	6.621051e-114	6.856167e+0	EGFR,OXA1L,PMAIP1,RTP3,RTP5	MammalianAncestor	111.857
GO.Biological.Process	GO:0050965	detection.of.temperature.stimulus.involved.in.sensory.perception.of.pain	22	1.811836e-113	2.340349e-109	1.063795e-110	7.209060e+0	CXCL12	MammalianAncestor	108.631
GO.Biological.Process	GO:0014910	regulation.of.smooth.muscle.cell.migration	23	2.342788e-113	3.026179e-109	1.315730e-110	3.218379e+0	HDAC4,IGFBP3,IQGAP1,LPAR1,MYOCD,PLXNA1,SERPINE1,TACR1	MammalianAncestor	108.519
GO.Biological.Process	GO:0000188	inactivation.of.MAPK.activity	24	7.193514e-111	9.291862e-107	3.871609e-108	4.967243e+0	DUSP1,DUSP22,DUSP4,PPP2R1A,RGS4	MammalianAncestor	106.032
GO.Biological.Process	GO:0010675	regulation.of.cellular.carbohydrate.metabolic.process	25	3.220567e-110	4.160006e-106	1.664003e-107	2.803413e+0	ACTN3,CD244,DUSP12,HDAC4,IGFBP3,INSR,PFKFB1,PMAIP1,POU1F1,PPP1R3F,RGN,SLC35B4,SORBS1	MammalianAncestor	105.381
GO.Biological.Process	GO:0033605	positive.regulation.of.catecholamine.secretion	26	5.658305e-109	7.308833e-105	2.811089e-106	6.839889e+0	CXCL12	MammalianAncestor	104.136
GO.Biological.Process	GO:0070098	chemokine-mediated.signaling.pathway	27	1.824494e-108	2.356699e-104	8.728514e-106	4.581612e+0	ACKR1,CCL24,CCL25,CCL26,CCR5,CCRL2,CX3CR1,CXCL12,GPR35	MammalianAncestor	103.628
GO.Biological.Process	GO:0045773	positive.regulation.of.axon.extension	28	3.213547e-108	4.150939e-104	1.482478e-105	3.488114e+0	CXCL12,FN1,LIMK1,MAPT,NRG1,TRPV2	MammalianAncestor	103.382
GO.Biological.Process	GO:2000401	regulation.of.lymphocyte.migration	29	4.802435e-107	6.203305e-103	2.139071e-104	4.362274e+0	AIRE,APOD,CXCL12,GCSAM,GCSAML,STK10	MammalianAncestor	102.207
GO.Biological.Process	GO:0050911	detection.of.chemical.stimulus.involved.in.sensory.perception.of.smell	30	4.477485e-106	5.783567e-102	1.927856e-103	2.888452e+0	ENSG00000182974,OR10H1,OR10H2,OR10H3,OR10H4,OR10H5,OR10J1,OR10J3,OR10J5,OR10T2,OR13A1,OR13D1,OR13F1,OR13H1,OR14I1,OR1M1,OR2A1,OR2AE1,OR2B11,OR2C3,OR2F2,OR2G2,OR2H2,OR2K2,OR2V1,OR2V2,OR2W1,OR2Y1,OR4C12,OR4E2,OR4F15,OR4F16,OR4F17,OR4F29,OR4F4,OR4F5,OR4F6,OR4N4,OR6B2,OR6B3,OR6K2,OR6K3,OR6K6,OR6N1,OR6N2,OR6S1,OR9A4	MammalianAncestor	101.238
GO.Biological.Process	GO:0048286	lung.alveolus.development	31	1.058261e-104	1.366956e-100	4.409535e-102	3.373622e+0	FLT4,HS6ST1,MYOCD,PKDCC,SFTPD,TNS3	MammalianAncestor	99.8642
GO.Biological.Process	GO:0043567	regulation.of.insulin-like.growth.factor.receptor.signaling.pathway	32	2.387428e-103	3.083841e-99	9.637002e-101	4.812088e+0	IGFBP1,IGFBP3,POU1F1	MammalianAncestor	98.5109
GO.Biological.Process	GO:0048669	collateral.sprouting.in.absence.of.injury	33	1.807951e-102	2.335330e-98	7.076759e-100	1.011915e+1	COBL	MammalianAncestor	97.6317
GO.Biological.Process	GO:0006919	activation.of.cysteine-type.endopeptidase.activity.involved.in.apoptotic.process	34	2.602326e-102	3.361424e-98	9.886543e-100	3.359761e+0	ANP32B,BAK1,BEX3,CARD8,CTSH,FASLG,HIP1,MAPT,NGF,NLRP1,NLRP12,NLRP3,PDCD6,PMAIP1,RACK1,RIPK1,XDH	MammalianAncestor	97.4735
GO.Biological.Process	GO:0007606	sensory.perception.of.chemical.stimulus	35	3.685812e-102	4.760963e-98	1.360275e-99	2.407862e+0	AZGP1,CNGA2,CST1,CST2,CST4,ENSG00000182974,OR10H1,OR10H2,OR10H3,OR10H4,OR10H5,OR10J1,OR10J3,OR10J5,OR10T2,OR13A1,OR13D1,OR13F1,OR13H1,OR14I1,OR1M1,OR2A1,OR2AE1,OR2B11,OR2C3,OR2F2,OR2G2,OR2H2,OR2K2,OR2V1,OR2V2,OR2W1,OR2Y1,OR4C12,OR4E2,OR4F15,OR4F16,OR4F17,OR4F29,OR4F4,OR4F5,OR4F6,OR4N4,OR6B2,OR6B3,OR6K2,OR6K3,OR6K6,OR6N1,OR6N2,OR6S1,OR9A4,RTP3,RTP5,SYT10,TAS2R3,TAS2R38,TAS2R4,TAS2R5,UGT2A1,UGT2A2	MammalianAncestor	97.3223
GO.Biological.Process	GO:0019730	antimicrobial.humoral.response	36	9.467366e-101	1.222900e-96	3.396944e-98	5.086796e+0	CAMP,CLU,CST9,CTSG,DEFA1,DEFA3,DEFA4,DEFA5,DEFA6,DEFB1,DEFB103A,DEFB103B,DEFB4A,DEFB4B,GNLY,HIST1H2BJ,HIST1H2BK,HTN1,HTN3,ITLN1,JCHAIN,KLK3,LTF,REG3A,REG3G,RNASE3,RNASE6,RNASE7,SFTPD	MammalianAncestor	95.9126
GO.Biological.Process	GO:0010193	response.to.ozone	37	4.878814e-99	6.301964e-95	1.703234e-96	1.199447e+1	CYP2E1,SCGB1A1,TACR1	MammalianAncestor	94.2005
GO.Biological.Process	GO:0002823	negative.regulation.of.adaptive.immune.response.based.on.somatic.recombination.of.immune.receptors.built.from.immunoglobulin.superfamily.domains	38	3.322410e-97	4.291557e-93	1.129357e-94	4.883581e+0	CEACAM1,DUSP22,FCGR2B,IL20RB,IL4R,SLAMF1,SPN,TNFSF18,TNFSF4	MammalianAncestor	92.3674
GO.Biological.Process	GO:2000329	negative.regulation.of.T-helper.17.cell.lineage.commitment	39	8.098746e-97	1.046115e-92	2.682346e-94	2.197980e+1	TNFSF18	MammalianAncestor	91.9804
GO.Biological.Process	GO:0002309	T.cell.proliferation.involved.in.immune.response	40	8.158507e-97	1.053834e-92	2.634586e-94	1.830395e+1	CD86,TNFSF18	MammalianAncestor	91.9772
GO.Biological.Process	GO:0007608	sensory.perception.of.smell	41	9.969731e-97	1.287790e-92	3.140952e-94	2.545498e+0	CNGA2,ENSG00000182974,OR10H1,OR10H2,OR10H3,OR10H4,OR10H5,OR10J1,OR10J3,OR10J5,OR10T2,OR13A1,OR13D1,OR13F1,OR13H1,OR14I1,OR1M1,OR2A1,OR2AE1,OR2B11,OR2C3,OR2F2,OR2G2,OR2H2,OR2K2,OR2V1,OR2V2,OR2W1,OR2Y1,OR4C12,OR4E2,OR4F15,OR4F16,OR4F17,OR4F29,OR4F4,OR4F5,OR4F6,OR4N4,OR6B2,OR6B3,OR6K2,OR6K3,OR6K6,OR6N1,OR6N2,OR6S1,OR9A4,SYT10,UGT2A1,UGT2A2	MammalianAncestor	91.8902
GO.Biological.Process	GO:0009593	detection.of.chemical.stimulus	42	1.674359e-96	2.162770e-92	5.149451e-94	2.362603e+0	AZGP1,CASR,CST1,CST2,CST4,ENSG00000182974,LBP,OR10H1,OR10H2,OR10H3,OR10H4,OR10H5,OR10J1,OR10J3,OR10J5,OR10T2,OR13A1,OR13D1,OR13F1,OR13H1,OR14I1,OR1M1,OR2A1,OR2AE1,OR2B11,OR2C3,OR2F2,OR2G2,OR2H2,OR2K2,OR2V1,OR2V2,OR2W1,OR2Y1,OR4C12,OR4E2,OR4F15,OR4F16,OR4F17,OR4F29,OR4F4,OR4F5,OR4F6,OR4N4,OR6B2,OR6B3,OR6K2,OR6K3,OR6K6,OR6N1,OR6N2,OR6S1,OR9A4,RTP3,RTP5,TAS2R3,TAS2R38,TAS2R4,TAS2R5,UGT2A1,UGT2A2	MammalianAncestor	91.665
GO.Biological.Process	GO:0060378	regulation.of.brood.size	43	4.536249e-96	5.859473e-92	1.362668e-93	3.579222e+1	SH3PXD2B	MammalianAncestor	91.2321
GO.Biological.Process	GO:0048842	positive.regulation.of.axon.extension.involved.in.axon.guidance	44	1.051500e-95	1.358223e-91	3.086869e-93	5.839737e+0	CXCL12	MammalianAncestor	90.867
GO.Biological.Process	GO:1902229	regulation.of.intrinsic.apoptotic.signaling.pathway.in.response.to.DNA.damage	45	3.900863e-95	5.038745e-91	1.119721e-92	4.795682e+0	CLU,CXCL12,FBXO18,KDM1A,RPL26,TAF9B	MammalianAncestor	90.2977
GO.Biological.Process	GO:1902669	positive.regulation.of.axon.guidance	46	1.982873e-94	2.561277e-90	5.567994e-92	5.750196e+0	CXCL12	MammalianAncestor	89.5915
GO.Biological.Process	GO:1902230	negative.regulation.of.intrinsic.apoptotic.signaling.pathway.in.response.to.DNA.damage	47	2.293004e-93	2.961873e-89	6.301858e-91	4.958790e+0	CLU,CXCL12,KDM1A,TAF9B	MammalianAncestor	88.5284
GO.Biological.Process	GO:0051639	actin.filament.network.formation	48	5.401449e-93	6.977052e-89	1.453552e-90	6.207793e+0	COBL,FHOD3	MammalianAncestor	88.1563
GO.Biological.Process	GO:0051601	exocyst.localization	49	2.903151e-92	3.750000e-88	7.653062e-90	9.554875e+0	EXOC3,EXOC8,STXBP6	MammalianAncestor	87.426
GO.Biological.Process	GO:1900169	regulation.of.glucocorticoid.mediated.signaling.pathway	50	1.839161e-91	2.375644e-87	4.751289e-89	1.687170e+1	AKAP13	MammalianAncestor	86.6242
GO.Biological.Process	GO:1904237	positive.regulation.of.substrate-dependent.cell.migration,.cell.attachment.to.substrate	51	3.553894e-91	4.590565e-87	9.001108e-89	2.096702e+1	FN1	MammalianAncestor	86.3381
GO.Biological.Process	GO:2001202	negative.regulation.of.transforming.growth.factor-beta.secretion	51	3.553894e-91	4.590565e-87	9.001108e-89	2.096702e+1	FN1	MammalianAncestor	86.3381
GO.Biological.Process	GO:0010917	negative.regulation.of.mitochondrial.membrane.potential	53	3.834006e-91	4.952386e-87	9.344124e-89	1.257057e+1	MAPT,PMAIP1	MammalianAncestor	86.3052
GO.Biological.Process	GO:2000404	regulation.of.T.cell.migration	54	6.965105e-91	8.996826e-87	1.666079e-88	4.665637e+0	AIRE,APOD,CXCL12	MammalianAncestor	86.0459
GO.Biological.Process	GO:0071395	cellular.response.to.jasmonic.acid.stimulus	55	1.718833e-89	2.220217e-85	4.036757e-87	2.501181e+1	AKR1C1,AKR1C2,AKR1C3,AKR1C4	MammalianAncestor	84.6536
GO.Biological.Process	GO:0019731	antibacterial.humoral.response	56	6.478793e-88	8.368657e-84	1.494403e-85	8.244128e+0	CAMP,CTSG,DEFA1,DEFA3,DEFA4,DEFB1,HIST1H2BJ,HIST1H2BK,JCHAIN,KLK3,LTF,RNASE3,RNASE6,RNASE7,SFTPD	MammalianAncestor	83.0773
GO.Biological.Process	GO:0019585	glucuronate.metabolic.process	57	1.940784e-87	2.506911e-83	4.398089e-85	9.346507e+0	SORD,UGT2A1,UGT2A2,UGT2A3,UGT2B15,UGT2B17,UGT2B4,UGT2B7,XYLB	MammalianAncestor	82.6009
GO.Biological.Process	GO:0002526	acute.inflammatory.response	58	4.297937e-87	5.551645e-83	9.571802e-85	3.482436e+0	APCS,APOA2,CRP,DEFB1,FN1,LBP,MRGPRX1,ORM1,ORM2,REG3A,REG3G,TACR1,TFR2,TNFSF4	MammalianAncestor	82.2556
GO.Biological.Process	GO:0050930	induction.of.positive.chemotaxis	59	4.757879e-87	6.145752e-83	1.041653e-84	5.253074e+0	CXCL12	MammalianAncestor	82.2114
GO.Biological.Process	GO:0001824	blastocyst.development	60	1.192050e-86	1.539771e-82	2.566285e-84	3.649857e+0	DAD1,ETV2,GINS1,HNF1B,HOPX,POU5F1,RPL7L1,SBDS,SPIC,TAF8,TGFBR1	MammalianAncestor	81.8125
GO.Biological.Process	GO:2001242	regulation.of.intrinsic.apoptotic.signaling.pathway	61	2.079359e-85	2.685908e-81	4.403128e-83	2.643455e+0	CLU,CXCL12,FBXO18,FIS1,HSPA1A,KDM1A,LRRK2,MAGEA3,MAPK7,NCK1,PLAUR,PMAIP1,PTTG1IP,RACK1,RPL26,SGMS1,TAF9B	MammalianAncestor	80.5709
GO.Biological.Process	GO:0051606	detection.of.stimulus	62	1.043151e-84	1.347438e-80	2.173287e-82	1.847141e+0	AZGP1,CABP4,CASR,CD1D,CST1,CST2,CST4,CXCL12,ENSG00000182974,ENSG00000214732,GUCA1B,LBP,MRPS35,NLRP3,OR10H1,OR10H2,OR10H3,OR10H4,OR10H5,OR10J1,OR10J3,OR10J5,OR10T2,OR13A1,OR13D1,OR13F1,OR13H1,OR14I1,OR1M1,OR2A1,OR2AE1,OR2B11,OR2C3,OR2F2,OR2G2,OR2H2,OR2K2,OR2V1,OR2V2,OR2W1,OR2Y1,OR4C12,OR4E2,OR4F15,OR4F16,OR4F17,OR4F29,OR4F4,OR4F5,OR4F6,OR4N4,OR6B2,OR6B3,OR6K2,OR6K3,OR6K6,OR6N1,OR6N2,OR6S1,OR9A4,PKD1L1,RGR,RTP3,RTP5,TACR1,TAS2R3,TAS2R38,TAS2R4,TAS2R5,TMC2,UGT2A1,UGT2A2,ZBTB32	MammalianAncestor	79.8705
GO.Biological.Process	GO:0001757	somite.specification	63	2.950614e-83	3.811308e-79	6.049695e-81	7.449208e+0	COBL	MammalianAncestor	78.4189
GO.Biological.Process	GO:0001906	cell.killing	64	1.333334e-82	1.722268e-78	2.691043e-80	3.853590e+0	CAMP,CST11,CTSG,CTSH,DEFA1,DEFA3,DEFA4,DEFA5,DEFA6,DEFB103A,DEFB103B,DEFB128,DEFB132,DEFB4A,DEFB4B,GNLY,GZMB,HIST1H2BJ,HIST1H2BK,HTN1,HTN3,LTF,MICB,MUC7,REG3G,RPS19,SLAMF7,VAMP7	MammalianAncestor	77.7639
GO.Biological.Process	GO:0052695	cellular.glucuronidation	65	2.194880e-82	2.835126e-78	4.361733e-80	1.113381e+1	UGT2A1,UGT2A2,UGT2A3,UGT2B15,UGT2B17,UGT2B4,UGT2B7	MammalianAncestor	77.5474
GO.Biological.Process	GO:0046902	regulation.of.mitochondrial.membrane.permeability	66	7.843933e-82	1.013201e-77	1.535153e-79	3.335754e+0	BAK1,GZMB,HK2,HSPA1A,MTRNR2L5,PMAIP1,YWHAE	MammalianAncestor	76.9943
GO.Biological.Process	GO:0043568	positive.regulation.of.insulin-like.growth.factor.receptor.signaling.pathway	67	2.526502e-81	3.263483e-77	4.870870e-79	5.674321e+0	IGFBP3	MammalianAncestor	76.4863
GO.Biological.Process	GO:0090559	regulation.of.membrane.permeability	68	8.643655e-81	1.116501e-76	1.641913e-78	3.145428e+0	BAK1,DEFA5,F11R,GZMB,HK2,HSPA1A,MTRNR2L5,PMAIP1,YWHAE	MammalianAncestor	75.9521
GO.Biological.Process	GO:0045626	negative.regulation.of.T-helper.1.cell.differentiation	69	2.636668e-80	3.405784e-76	4.935919e-78	2.214301e+1	IL4R,TNFSF4	MammalianAncestor	75.4678
GO.Biological.Process	GO:2000406	positive.regulation.of.T.cell.migration	70	1.234708e-79	1.594872e-75	2.278389e-77	4.787597e+0	CXCL12	MammalianAncestor	74.7973
GO.Biological.Process	GO:0030516	regulation.of.axon.extension	71	1.375820e-79	1.777147e-75	2.503024e-77	2.468673e+0	CXCL12,FN1,LIMK1,MAPT,NRCAM,NRG1,PLXNA1,SEMA4F,TRPV2	MammalianAncestor	74.7503
GO.Biological.Process	GO:1900029	positive.regulation.of.ruffle.assembly	72	2.749887e-79	3.552029e-75	4.933374e-77	5.737575e+0	COBL,FAM98A,PLEKHM1	MammalianAncestor	74.4495
GO.Biological.Process	GO:0002480	antigen.processing.and.presentation.of.exogenous.peptide.antigen.via.MHC.class.I,.TAP-independent	73	2.994795e-79	3.868377e-75	5.299146e-77	1.499380e+1	B2M,HLA-B,HLA-F,HLA-G	MammalianAncestor	74.4125
GO.Biological.Process	GO:0048662	negative.regulation.of.smooth.muscle.cell.proliferation	74	1.794090e-78	2.317426e-74	3.131657e-76	3.479211e+0	ANG,APOD,IGFBP3,MYOCD,NDRG2,VIPR2	MammalianAncestor	73.635
GO.Biological.Process	GO:0044597	daunorubicin.metabolic.process	75	4.252708e-78	5.493223e-74	7.324297e-76	1.120683e+1	AKR1B1,AKR1C1,AKR1C2,AKR1C3,AKR1C4	MammalianAncestor	73.2602
GO.Biological.Process	GO:0044598	doxorubicin.metabolic.process	75	4.252708e-78	5.493223e-74	7.324297e-76	1.120683e+1	AKR1B1,AKR1C1,AKR1C2,AKR1C3,AKR1C4	MammalianAncestor	73.2602
GO.Biological.Process	GO:0002687	positive.regulation.of.leukocyte.migration	77	5.443351e-78	7.031176e-74	9.131398e-76	2.633560e+0	CCL24,CXCL12,CXCL17,FPR2,LBP,SERPINE1,SLAMF1,TACR1,TNFSF18	MammalianAncestor	73.153
GO.Biological.Process	GO:1901750	leukotriene.D4.biosynthetic.process	78	6.387037e-78	8.250136e-74	1.057710e-75	9.900522e+0	GGT1,GGT2,GGT6,GGTLC1,GGTLC2	MammalianAncestor	73.0835
GO.Biological.Process	GO:0050650	chondroitin.sulfate.proteoglycan.biosynthetic.process	79	1.121365e-77	1.448467e-73	1.833503e-75	3.752498e+0	B3GAT1,CHST13,CHST7,CHSY3,CSGALNACT1,CSGALNACT2,CSPG4,PXYLP1,XYLT2	MammalianAncestor	72.8391
GO.Biological.Process	GO:0002690	positive.regulation.of.leukocyte.chemotaxis	80	2.844797e-77	3.674624e-73	4.593280e-75	2.950543e+0	CXCL12,CXCL17,FPR2,LBP,SERPINE1,SLAMF1,TNFSF18	MammalianAncestor	72.4348
GO.Biological.Process	GO:0030647	aminoglycoside.antibiotic.metabolic.process	81	6.625322e-77	8.557928e-73	1.056534e-74	1.091935e+1	AKR1B1,AKR1C1,AKR1C2,AKR1C3,AKR1C4	MammalianAncestor	72.0676
GO.Biological.Process	GO:0052047	interaction.with.other.organism.via.secreted.substance.involved.in.symbiotic.interaction	82	3.693479e-76	4.770867e-72	5.818130e-74	1.442284e+1	FN1	MammalianAncestor	71.3214
GO.Biological.Process	GO:0098542	defense.response.to.other.organism	83	7.173835e-76	9.266443e-72	1.116439e-73	1.973206e+0	ACP5,CAMP,CD160,CD207,CD86,CRP,CST11,CTSG,DEFA1,DEFA3,DEFA4,DEFA5,DEFA6,DEFB1,DEFB103A,DEFB103B,DEFB107A,DEFB107B,DEFB108B,DEFB115,DEFB116,DEFB121,DEFB123,DEFB124,DEFB125,DEFB126,DEFB127,DEFB128,DEFB129,DEFB130A,DEFB130B,DEFB131B,DEFB132,DEFB134,DEFB135,DEFB136,DEFB4A,DEFB4B,ENSG00000259680,GALP,GNLY,HIST1H2BJ,HIST1H2BK,HTN1,HTN3,IFI16,IGLL5,IL17RA,IL4R,JCHAIN,KLK3,LBP,LTA,LTF,LYPD8,MAVS,NLRP1,NLRP3,NLRP9,OAS1,OAS2,OAS3,PMAIP1,POLR3K,REG3G,RNASE2,RNASE3,RNASE6,RNASE7,RNASE8,RPS19,SERINC5,SERPINE1,SFTPD,SPACA4,SPACA5,SPACA5B,SPN,STATH,TNFSF4,TRIM11,TRIM56,VGF,ZMYND11,ZNF175	MammalianAncestor	71.0331
GO.Biological.Process	GO:0045630	positive.regulation.of.T-helper.2.cell.differentiation	84	1.085525e-75	1.402173e-71	1.669253e-73	1.143386e+1	CD86,IL4R,NLRP3,TNFSF4	MammalianAncestor	70.8532
GO.Biological.Process	GO:0006691	leukotriene.metabolic.process	85	2.034258e-75	2.627651e-71	3.091354e-73	5.061165e+0	ALOX12,ALOX15,ALOX5,CYP4F12,CYP4F2,CYP4F3,FCER1A,GGT1,GGT2,GGT6,GGTLC1,GGTLC2	MammalianAncestor	70.5804
GO.Biological.Process	GO:0048841	regulation.of.axon.extension.involved.in.axon.guidance	86	2.356788e-75	3.044263e-71	3.539841e-73	3.520523e+0	CXCL12,PLXNA1	MammalianAncestor	70.5165
GO.Biological.Process	GO:0002686	negative.regulation.of.leukocyte.migration	87	5.383946e-75	6.954443e-71	7.993613e-73	3.646280e+0	APOD,CCL25,CXCL12,GCSAM	MammalianAncestor	70.1577
GO.Biological.Process	GO:0050868	negative.regulation.of.T.cell.activation	88	2.116384e-74	2.733733e-70	3.106515e-72	2.617639e+0	BTN2A2,CEACAM1,DLG1,DTX1,DUSP22,FCGR2B,HLA-G,IL20RB,IL2RA,IL4R,LILRB2,NFKBID,PRNP,SCGB1A1,SFTPD,SPN,TARM1,TNFSF18,TNFSF4	MammalianAncestor	69.5632
GO.Biological.Process	GO:0051168	nuclear.export	89	1.424785e-73	1.840395e-69	2.067859e-71	2.514530e+0	AKAP13,ATP6V1G2-DDX39B,CCHCR1,NCBP2,NPAP1,NUP205,NUP88,NXF2,NXF2B,NXF3,NXF5,POM121L12,POM121L2,RBMX2,XPO6	MammalianAncestor	68.7351
GO.Biological.Process	GO:2000403	positive.regulation.of.lymphocyte.migration	90	2.145003e-73	2.770700e-69	3.078556e-71	4.420173e+0	CXCL12	MammalianAncestor	68.5574
GO.Biological.Process	GO:0002685	regulation.of.leukocyte.migration	91	7.629803e-73	9.855417e-69	1.083013e-70	2.263968e+0	AIRE,APOD,CCL24,CCL25,CXCL12,CXCL17,FPR2,GCSAM,GCSAML,LBP,SERPINE1,SLAMF1,STK10,TACR1,TNFSF18	MammalianAncestor	68.0063
GO.Biological.Process	GO:0046666	retinal.cell.programmed.cell.death	92	1.830526e-72	2.364490e-68	2.570098e-70	2.126115e+1	FASLG	MammalianAncestor	67.6263
GO.Biological.Process	GO:0051924	regulation.of.calcium.ion.transport	93	1.852515e-72	2.392894e-68	2.573004e-70	1.951237e+0	AHNAK,BAK1,CACNA1B,CASR,CD84,CLIC2,CRHR1,CXCL12,DHRS7C,EHD3,FCRL3,GPR35,LILRB2,NOS1AP,OR13F1,PRNP,RAMP3,REM1,RGN,SARAF,SLC8A1,TMC2,TRIM27,TRPV2,YWHAE	MammalianAncestor	67.6211
GO.Biological.Process	GO:0016048	detection.of.temperature.stimulus	94	2.794840e-72	3.610095e-68	3.840526e-70	4.356730e+0	CXCL12	MammalianAncestor	67.4425
GO.Biological.Process	GO:1904179	positive.regulation.of.adipose.tissue.development	95	4.577762e-71	5.913095e-67	6.224311e-69	1.366196e+1	GHRL,SH3PXD2B	MammalianAncestor	66.2282
GO.Biological.Process	GO:0010906	regulation.of.glucose.metabolic.process	96	2.113914e-70	2.730543e-66	2.844315e-68	2.591844e+0	ACTN3,DUSP12,IGFBP3,INSR,PFKFB1,PMAIP1,PPP1R3F,RGN,SLC35B4,SORBS1	MammalianAncestor	65.5638
GO.Biological.Process	GO:0042267	natural.killer.cell.mediated.cytotoxicity	97	2.197518e-70	2.838534e-66	2.926324e-68	8.018761e+0	GZMB,MICB,SLAMF7,VAMP7	MammalianAncestor	65.5469
GO.Biological.Process	GO:2000508	regulation.of.dendritic.cell.chemotaxis	98	3.182676e-70	4.111063e-66	4.194962e-68	8.643641e+0	SLAMF1,TNFSF18	MammalianAncestor	65.386
GO.Biological.Process	GO:0009410	response.to.xenobiotic.stimulus	99	3.560522e-70	4.599126e-66	4.645582e-68	2.826432e+0	AHRR,AIP,AKR1C1,CYP1B1,CYP2E1,CYP3A4,CYP3A5,CYP3A7,CYP3A7-CYP3A51P,EPHX2,GGT1,MCM7,NAT1,NAT2,NQO2,RHBDD3,SCGB1A1,SULT1A3,SULT1B1,UGT2B15,UGT2B28,UGT2B4	MammalianAncestor	65.3373
GO.Biological.Process	GO:0070086	ubiquitin-dependent.endocytosis	100	7.381001e-70	9.534039e-66	9.534039e-68	2.424643e+1	NEURL1B	MammalianAncestor	65.0207
GO.Biological.Process	GO:0002691	regulation.of.cellular.extravasation	101	1.295616e-69	1.673547e-65	1.656977e-67	4.052476e+0	CCL25,CXCL12	MammalianAncestor	64.7764
GO.Biological.Process	GO:1900027	regulation.of.ruffle.assembly	102	2.046498e-69	2.643461e-65	2.591629e-67	4.086792e+0	COBL,FAM98A,PLEKHM1,SH3YL1,USP17L2	MammalianAncestor	64.5778
GO.Biological.Process	GO:0035795	negative.regulation.of.mitochondrial.membrane.permeability	103	4.109512e-69	5.308257e-65	5.153647e-67	7.285898e+0	HK2,MTRNR2L5	MammalianAncestor	64.275
GO.Biological.Process	GO:0051954	positive.regulation.of.amine.transport	104	4.696051e-69	6.065889e-65	5.832586e-67	3.762157e+0	CXCL12,TRH	MammalianAncestor	64.2171
GO.Biological.Process	GO:0033504	floor.plate.development	105	4.884909e-69	6.309837e-65	6.009369e-67	5.882629e+0	COBL	MammalianAncestor	64.2
GO.Biological.Process	GO:1904925	positive.regulation.of.mitophagy.in.response.to.mitochondrial.depolarization	106	2.622481e-68	3.387459e-64	3.195716e-66	2.298979e+1	HK2	MammalianAncestor	63.4701
GO.Biological.Process	GO:0002228	natural.killer.cell.mediated.immunity	107	2.972998e-68	3.840222e-64	3.588992e-66	7.679945e+0	GZMB,MICB,SLAMF7,VAMP7	MammalianAncestor	63.4156
GO.Biological.Process	GO:0010952	positive.regulation.of.peptidase.activity	108	1.525692e-67	1.970736e-63	1.824756e-65	2.190041e+0	AIM2,ALOX12,ANP32B,BAK1,BEX3,CARD8,CTSH,FASLG,FIS1,FN1,HIP1,IFI16,MAPT,NGF,NLRP1,NLRP12,NLRP3,PCOLCE,PDCD6,PMAIP1,RACK1,REST,RIPK1,XDH	MammalianAncestor	62.7054
GO.Biological.Process	GO:1904177	regulation.of.adipose.tissue.development	109	1.703721e-67	2.200696e-63	2.018988e-65	1.242858e+1	GHRL,SH3PXD2B	MammalianAncestor	62.6574
GO.Biological.Process	GO:0051122	hepoxilin.biosynthetic.process	110	2.580672e-67	3.333454e-63	3.030413e-65	2.373986e+1	ALOX12,ALOX12B,ALOX15,ALOX15B,ALOXE3	MammalianAncestor	62.4771
GO.Biological.Process	GO:0014912	negative.regulation.of.smooth.muscle.cell.migration	111	5.648560e-67	7.296245e-63	6.573194e-65	3.837679e+0	IGFBP3,MYOCD,SERPINE1	MammalianAncestor	62.1369
GO.Biological.Process	GO:0035786	protein.complex.oligomerization	112	5.663209e-67	7.315167e-63	6.531399e-65	1.889510e+1	BLM	MammalianAncestor	62.1358
GO.Biological.Process	GO:0002683	negative.regulation.of.immune.system.process	113	6.476890e-67	8.366199e-63	7.403716e-65	1.681007e+0	ALOX15,AMBP,APCS,APOA2,APOD,BTN2A2,CCL25,CD200,CD84,CD86,CEACAM1,CUEDC2,CXCL12,DLG1,DTX1,DUSP22,FCGR2B,FCRL3,FCRLB,GCSAM,HIST1H4H,HIST1H4I,HLA-DOB,HLA-G,HMGB3,IFI16,IL20RB,IL2RA,IL4R,KLF13,LILRB2,LILRB3,LTF,MICB,MNDA,NFKBID,NFKBIL1,NLRP2B,PARP14,PDCD1,PRNP,PVRIG,RHBDD3,RPS19,SCGB1A1,SERPINB9,SFTPD,SLAMF1,SPN,TARM1,TMEM178A,TNFRSF13B,TNFSF18,TNFSF4,TRIM27,TSC22D3	MammalianAncestor	62.0775
GO.Biological.Process	GO:0006109	regulation.of.carbohydrate.metabolic.process	114	1.536784e-66	1.985064e-62	1.741284e-64	2.135376e+0	ACTN3,CD244,DUSP12,HDAC4,IGFBP3,INSR,NUP205,NUP88,PFKFB1,PFKFB4,PMAIP1,POU1F1,PPP1R3F,RGN,SLC35B4,SORBS1	MammalianAncestor	61.7022
GO.Biological.Process	GO:0030166	proteoglycan.biosynthetic.process	115	1.606340e-66	2.074909e-62	1.804269e-64	2.457111e+0	B3GAT1,CHST13,CHST7,CHSY3,CSGALNACT1,CSGALNACT2,CSPG4,HS6ST1,PXYLP1,VANGL2,XYLT2	MammalianAncestor	61.683
GO.Biological.Process	GO:0043280	positive.regulation.of.cysteine-type.endopeptidase.activity.involved.in.apoptotic.process	116	1.372294e-65	1.772592e-61	1.528097e-63	2.412678e+0	ALOX12,ANP32B,BAK1,BEX3,CARD8,CTSH,FASLG,FIS1,HIP1,MAPT,NGF,NLRP1,NLRP12,NLRP3,PDCD6,PMAIP1,RACK1,REST,RIPK1,XDH	MammalianAncestor	60.7514
GO.Biological.Process	GO:0006805	xenobiotic.metabolic.process	117	2.539386e-64	3.280125e-60	2.803526e-62	2.954828e+0	AHRR,AIP,AKR1C1,CYP1B1,CYP2E1,CYP3A4,CYP3A5,CYP3A7,CYP3A7-CYP3A51P,EPHX2,GGT1,NAT1,NAT2,NQO2,SULT1A3,SULT1B1,UGT2B15,UGT2B28,UGT2B4	MammalianAncestor	59.4841
GO.Biological.Process	GO:0043405	regulation.of.MAP.kinase.activity	118	3.048746e-64	3.938065e-60	3.337343e-62	1.638195e+0	ADORA2B,ADRA2B,AKAP13,ARAF,ARHGEF5,CHRNA7,CRKL,CSPG4,CXCL17,DBNL,DUSP1,DUSP22,DUSP4,EGFR,EPHB2,ERCC6,ERN2,FCER1A,FPR1,GHRL,INAVA,INSR,IQGAP1,IRAK2,LPAR1,LRRK2,MAGED1,MAP2K4,MAP2K7,MAP3K2,MAP4K3,MAPK7,MUC20,NGF,NRG1,PIK3CB,PPP2R1A,RGS4,RIPK1,STK26,TDGF1,TGFA,TGFBR1,VANGL2	MammalianAncestor	59.4047
GO.Biological.Process	GO:0007624	ultradian.rhythm	119	3.357882e-64	4.337376e-60	3.644854e-62	1.726825e+1	ENOX2	MammalianAncestor	59.3628
GO.Biological.Process	GO:0050951	sensory.perception.of.temperature.stimulus	120	4.047509e-64	5.228167e-60	4.356806e-62	3.911485e+0	CXCL12	MammalianAncestor	59.2817
GO.Biological.Process	GO:0009101	glycoprotein.biosynthetic.process	121	9.089189e-64	1.174051e-59	9.702897e-62	1.662396e+0	A4GNT,ADAMTS7,ALG10,ALG10B,ALG1L,ALG1L2,ASGR1,ASGR2,B3GAT1,B4GAT1,C1GALT1,CHST13,CHST7,CHSY3,CSGALNACT1,CSGALNACT2,CSPG4,DAD1,FUT10,GALNT1,GALNT12,GOLPH3,HS6ST1,MGAT1,MUC12,MUC16,MUC17,MUC20,MUC21,MUC4,MUC7,OAS2,PARP14,PLOD3,POMK,PXYLP1,RPN2,SDF2L1,SPON1,TNKS,VANGL2,XYLT2	MammalianAncestor	58.9303
GO.Biological.Process	GO:2001201	regulation.of.transforming.growth.factor-beta.secretion	122	1.439176e-63	1.858984e-59	1.523757e-61	1.045500e+1	FN1	MammalianAncestor	58.7307
GO.Biological.Process	GO:0006405	RNA.export.from.nucleus	123	4.001698e-63	5.168993e-59	4.202434e-61	2.666004e+0	ATP6V1G2-DDX39B,NCBP2,NPAP1,NUP205,NUP88,NXF2,NXF2B,NXF3,NXF5,POM121L12,POM121L2,RBMX2	MammalianAncestor	58.2866
GO.Biological.Process	GO:2001056	positive.regulation.of.cysteine-type.endopeptidase.activity	124	4.837442e-63	6.248524e-59	5.039132e-61	2.306197e+0	AIM2,ALOX12,ANP32B,BAK1,BEX3,CARD8,CTSH,FASLG,FIS1,HIP1,IFI16,MAPT,NGF,NLRP1,NLRP12,NLRP3,PDCD6,PMAIP1,RACK1,REST,RIPK1,XDH	MammalianAncestor	58.2042
GO.Biological.Process	GO:0071466	cellular.response.to.xenobiotic.stimulus	125	9.546587e-63	1.233133e-58	9.865061e-61	2.901718e+0	AHRR,AIP,AKR1C1,CYP1B1,CYP2E1,CYP3A4,CYP3A5,CYP3A7,CYP3A7-CYP3A51P,EPHX2,GGT1,MCM7,NAT1,NAT2,NQO2,SULT1A3,SULT1B1,UGT2B15,UGT2B28,UGT2B4	MammalianAncestor	57.909
GO.Biological.Process	GO:0045742	positive.regulation.of.epidermal.growth.factor.receptor.signaling.pathway	126	1.932224e-62	2.495854e-58	1.980836e-60	4.032575e+0	ADRA2B,FASLG,HIP1,PLAUR,TGFA	MammalianAncestor	57.6028
GO.Biological.Process	GO:0045087	innate.immune.response	127	3.999618e-62	5.166307e-58	4.067958e-60	1.665095e+0	AIM2,APCS,B2M,CAMP,CCL24,CCL25,CCL26,CD1D,CD244,CD84,CD86,CLEC10A,CLU,DEFA1,DEFA3,DEFA4,DEFA5,DEFB1,DEFB107A,DEFB107B,DEFB108B,DEFB115,DEFB116,DEFB121,DEFB123,DEFB124,DEFB125,DEFB126,DEFB127,DEFB128,DEFB129,DEFB131B,DEFB132,DEFB134,DEFB135,ENSG00000259680,FCGR1A,FCGR1B,GZMB,HIST1H2BJ,HIST1H2BK,HLA-B,HLA-DQA1,HLA-DQA2,HLA-DQB2,HLA-DRA,HLA-DRB1,HLA-DRB5,HLA-F,HLA-G,HMGB3,IFI16,IGLL5,INAVA,IRF6,JCHAIN,LBP,LTF,LY9,MAVS,MICB,MID2,NLRP1,NLRP2B,NLRP3,NLRP9,NUB1,OAS1,OAS2,OAS3,PIK3CB,POLR3K,RELB,RNASE3,RNASE6,RNASE7,RNASE8,S100B,SERINC5,SFTPD,SIGLEC10,SIGLEC14,SLAMF1,SLAMF6,SLAMF7,TARM1,TDGF1,TRIM10,TRIM11,TRIM14,TRIM15,TRIM26,TRIM27,TRIM31,TRIM4,TRIM56,TYROBP,UBD,VAMP7,ZAP70	MammalianAncestor	57.2868
GO.Biological.Process	GO:0050710	negative.regulation.of.cytokine.secretion	128	8.163435e-62	1.054471e-57	8.238054e-60	2.982500e+0	APOA2,BTN2A2,CARD8,FCGR2B,FN1,GHRL,NLRP12,NLRP3,SLAMF1,TNFSF4,TRIM27	MammalianAncestor	56.977
GO.Biological.Process	GO:0052547	regulation.of.peptidase.activity	129	1.851584e-61	2.391691e-57	1.854024e-59	1.702247e+0	AIM2,ALOX12,AMBP,ANP32B,ANXA8,BAK1,BEX3,CARD8,COL28A1,CRIM1,CSN2,CST1,CST11,CST2,CST3,CST4,CST5,CST7,CST8,CST9,CST9L,CSTL1,CTSH,ENSG00000267748,FASLG,FIS1,FN1,FURIN,HIP1,IFI16,LTF,MAGEA3,MAPT,NGF,NLRP1,NLRP12,NLRP3,OPRPN,PAK2,PAX2,PCOLCE,PCSK1N,PDCD6,PLAUR,PMAIP1,RACK1,REST,RIPK1,SERPINB6,SERPINB8,SERPINB9,SERPIND1,SERPINE1,SPINK2,SPINK8,SPINT2,USP14,WNT9A,XDH,YWHAE	MammalianAncestor	56.6213
GO.Biological.Process	GO:0033622	integrin.activation	130	3.160690e-61	4.082663e-57	3.140510e-59	9.836944e+0	FN1	MammalianAncestor	56.3891
GO.Biological.Process	GO:0015015	heparan.sulfate.proteoglycan.biosynthetic.process,.enzymatic.modification	131	5.188680e-61	6.702218e-57	5.116197e-59	4.822990e+0	HS6ST1	MammalianAncestor	56.1738
GO.Biological.Process	GO:0060073	micturition	132	5.274085e-61	6.812536e-57	5.161012e-59	6.554669e+0	ADRA1A,CHRNA3,CHRNB4,TACR1	MammalianAncestor	56.1667
GO.Biological.Process	GO:2000328	regulation.of.T-helper.17.cell.lineage.commitment	133	5.655752e-61	7.305535e-57	5.492883e-59	9.195132e+0	TNFSF18	MammalianAncestor	56.1363
GO.Biological.Process	GO:0006636	unsaturated.fatty.acid.biosynthetic.process	134	7.884138e-61	1.018394e-56	7.599956e-59	3.615891e+0	AKR1C3,ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,ALOXE3,FCER1A,GGT1,GGT2,GGT6,GGTLC1,GGTLC2	MammalianAncestor	55.9921
GO.Biological.Process	GO:0045837	negative.regulation.of.membrane.potential	135	8.987681e-61	1.160939e-56	8.599546e-59	6.778391e+0	MAPT,PMAIP1	MammalianAncestor	55.9352
GO.Biological.Process	GO:1904231	positive.regulation.of.succinate.dehydrogenase.activity	136	1.165088e-60	1.504944e-56	1.106577e-58	1.071054e+1	FTMT	MammalianAncestor	55.8225
GO.Biological.Process	GO:1904234	positive.regulation.of.aconitate.hydratase.activity	136	1.165088e-60	1.504944e-56	1.106577e-58	1.071054e+1	FTMT	MammalianAncestor	55.8225
GO.Biological.Process	GO:0050777	negative.regulation.of.immune.response	138	1.177042e-60	1.520385e-56	1.101728e-58	2.330080e+0	ALOX15,AMBP,APOA2,CD84,CEACAM1,CUEDC2,DUSP22,FCGR2B,FCRLB,HLA-G,IFI16,IL20RB,IL2RA,IL4R,LILRB2,PARP14,RPS19,SERPINB9,SLAMF1,SPN,TNFSF18,TNFSF4,TRIM27	MammalianAncestor	55.818
GO.Biological.Process	GO:0016137	glycoside.metabolic.process	139	6.500784e-60	8.397063e-56	6.041052e-58	7.391449e+0	AKR1B1,AKR1C1,AKR1C2,AKR1C3,AKR1C4,GLA	MammalianAncestor	55.0759
GO.Biological.Process	GO:0071800	podosome.assembly	140	1.143256e-59	1.476744e-55	1.054817e-57	1.060605e+1	DBNL,SH3PXD2B	MammalianAncestor	54.8307
GO.Biological.Process	GO:0019370	leukotriene.biosynthetic.process	141	1.184750e-59	1.530342e-55	1.085349e-57	5.235298e+0	ALOX5,FCER1A,GGT1,GGT2,GGT6,GGTLC1,GGTLC2	MammalianAncestor	54.8152
GO.Biological.Process	GO:0048388	endosomal.lumen.acidification	142	1.386209e-59	1.790566e-55	1.260962e-57	1.413176e+1	FASLG	MammalianAncestor	54.747
GO.Biological.Process	GO:0001844	protein.insertion.into.mitochondrial.membrane.involved.in.apoptotic.signaling.pathway	143	2.306561e-59	2.979385e-55	2.083486e-57	8.030942e+0	PMAIP1	MammalianAncestor	54.5259
GO.Biological.Process	GO:0048660	regulation.of.smooth.muscle.cell.proliferation	144	9.979583e-59	1.289063e-54	8.951825e-57	2.056617e+0	AKR1B1,ALOX12,ANG,APOD,ATP6V1G2-DDX39B,EGFR,HDAC4,IGFBP3,MYOCD,NDRG2,NQO2,TACR1,VIPR2	MammalianAncestor	53.8897
GO.Biological.Process	GO:0030041	actin.filament.polymerization	145	1.145927e-58	1.480194e-54	1.020823e-56	4.115127e+0	ANG,COBL,HCLS1,WAS	MammalianAncestor	53.8297
GO.Biological.Process	GO:0003051	angiotensin-mediated.drinking.behavior	146	1.374745e-58	1.775758e-54	1.216273e-56	1.336810e+1	TACR1	MammalianAncestor	53.7506
GO.Biological.Process	GO:1990535	neuron.projection.maintenance	147	2.340423e-58	3.023124e-54	2.056547e-56	8.368356e+0	INSR,PRNP	MammalianAncestor	53.5195
GO.Biological.Process	GO:0072656	maintenance.of.protein.location.in.mitochondrion	148	3.524984e-58	4.553222e-54	3.076501e-56	1.618230e+1	HK2	MammalianAncestor	53.3417
GO.Biological.Process	GO:0035542	regulation.of.SNARE.complex.assembly	149	4.507274e-58	5.822046e-54	3.907413e-56	7.087872e+0	STXBP6	MammalianAncestor	53.2349
GO.Biological.Process	GO:0033108	mitochondrial.respiratory.chain.complex.assembly	150	6.780330e-58	8.758152e-54	5.838768e-56	3.104053e+0	AARS2,ACAD9,COA1,COA5,DMAC2,LYRM7,NDUFA10,NDUFAB1,NDUFB11,OXA1L,SDHAF1,TFAM	MammalianAncestor	53.0576
GO.Biological.Process	GO:0032930	positive.regulation.of.superoxide.anion.generation	151	8.891407e-58	1.148503e-53	7.605980e-56	8.137432e+0	CD177,CRP,EGFR,FPR2,ITGB2,MAPT	MammalianAncestor	52.9399
GO.Biological.Process	GO:1901317	regulation.of.flagellated.sperm.motility	152	1.025661e-57	1.324846e-53	8.716094e-56	5.541981e+0	DEFB1,RGN,RNASE10,RNASE9,TACR1,TEX101	MammalianAncestor	52.8778
GO.Biological.Process	GO:0043408	regulation.of.MAPK.cascade	153	1.578217e-57	2.038583e-53	1.332407e-55	1.406600e+0	ADORA2B,ADRA1A,ADRA2B,AKAP13,ALKAL2,ALOX12B,ALOX15,AMBP,ARAF,ARHGEF5,BMP15,CCL24,CCL25,CCL26,CEACAM1,CHRNA7,CRKL,CSPG4,CXCL17,DBNL,DLG1,DUSP1,DUSP22,DUSP4,EGFR,EPHB2,ERCC6,ERN2,FCER1A,FCGR2B,FCRL3,FLT4,FN1,FPR1,FPR2,GDF10,GHRL,HTR2C,IGFBP3,IL11,INAVA,INSR,IQGAP1,IRAK2,LPAR1,LRRK2,MAGED1,MAP2K4,MAP2K7,MAP3K2,MAP4K3,MAPK7,MUC20,NDRG2,NGF,NLRP12,NQO2,NRG1,PAK2,PDE8A,PER1,PIK3CB,PPP2R1A,RAMP3,RASSF2,RGS4,RIPK1,SCIMP,SEMA4C,SLAMF1,STK26,TDGF1,TGFA,TGFBR1,UNC5CL,VANGL2,WNT7A,XDH,ZMYND11	MammalianAncestor	52.6907
GO.Biological.Process	GO:0009408	response.to.heat	154	1.614522e-57	2.085478e-53	1.354207e-55	2.433270e+0	CXCL12,HSPA1A,HSPA1B,HSPA6,MAP2K7,MAPT,MICB,PDCD6,TACR1,TRPV2,YWHAE	MammalianAncestor	52.6808
GO.Biological.Process	GO:0042742	defense.response.to.bacterium	155	2.965455e-57	3.830478e-53	2.471276e-55	2.103602e+0	ACP5,CAMP,CD160,CRP,CST11,CTSG,DEFA1,DEFA3,DEFA4,DEFA5,DEFA6,DEFB1,DEFB103A,DEFB103B,DEFB107A,DEFB107B,DEFB108B,DEFB115,DEFB116,DEFB121,DEFB123,DEFB124,DEFB125,DEFB126,DEFB127,DEFB128,DEFB129,DEFB130A,DEFB130B,DEFB131B,DEFB132,DEFB134,DEFB135,DEFB136,DEFB4A,DEFB4B,ENSG00000259680,GALP,GNLY,HIST1H2BJ,HIST1H2BK,HTN1,HTN3,IGLL5,JCHAIN,KLK3,LBP,LTA,LTF,LYPD8,MAVS,NLRP1,NLRP3,REG3G,RNASE3,RNASE6,RNASE7,RNASE8,RPS19,SERPINE1,SFTPD,SPACA4,SPACA5,SPACA5B,SPN,STATH,VGF	MammalianAncestor	52.4167
GO.Biological.Process	GO:0035709	memory.T.cell.activation	156	3.194361e-57	4.126156e-53	2.644972e-55	2.157871e+1	TNFSF4	MammalianAncestor	52.3845
GO.Biological.Process	GO:0035712	T-helper.2.cell.activation	156	3.194361e-57	4.126156e-53	2.644972e-55	2.157871e+1	TNFSF4	MammalianAncestor	52.3845
GO.Biological.Process	GO:0035714	cellular.response.to.nitrogen.dioxide	156	3.194361e-57	4.126156e-53	2.644972e-55	2.157871e+1	TNFSF4	MammalianAncestor	52.3845
GO.Biological.Process	GO:0035783	CD4-positive,.alpha-beta.T.cell.costimulation	156	3.194361e-57	4.126156e-53	2.644972e-55	2.157871e+1	TNFSF4	MammalianAncestor	52.3845
GO.Biological.Process	GO:0071954	chemokine.(C-C.motif).ligand.11.production	156	3.194361e-57	4.126156e-53	2.644972e-55	2.157871e+1	TNFSF4	MammalianAncestor	52.3845
GO.Biological.Process	GO:1900281	positive.regulation.of.CD4-positive,.alpha-beta.T.cell.costimulation	156	3.194361e-57	4.126156e-53	2.644972e-55	2.157871e+1	TNFSF4	MammalianAncestor	52.3845
GO.Biological.Process	GO:2000572	positive.regulation.of.interleukin-4-dependent.isotype.switching.to.IgE.isotypes	156	3.194361e-57	4.126156e-53	2.644972e-55	2.157871e+1	TNFSF4	MammalianAncestor	52.3845
GO.Biological.Process	GO:0060716	labyrinthine.layer.blood.vessel.development	163	1.123596e-56	1.451349e-52	8.903981e-55	4.299333e+0	HS6ST1,NSDHL	MammalianAncestor	51.8382
GO.Biological.Process	GO:0072593	reactive.oxygen.species.metabolic.process	164	3.323282e-56	4.292683e-52	2.617490e-54	2.342840e+0	ALOX12,CCS,CYP1B1,DDAH2,DUOX1,DUOX2,EGFR,EPHX2,INAVA,LRRK2,PAX2,PMAIP1,PRDX6,SFTPD,SH3PXD2B,TPO	MammalianAncestor	51.3673
GO.Biological.Process	GO:0006953	acute-phase.response	165	3.542699e-56	4.576104e-52	2.773397e-54	3.909506e+0	APCS,CRP,FN1,LBP,MRGPRX1,ORM1,ORM2,REG3A,REG3G,TFR2	MammalianAncestor	51.3395
GO.Biological.Process	GO:1901030	positive.regulation.of.mitochondrial.outer.membrane.permeabilization.involved.in.apoptotic.signaling.pathway	166	9.623501e-56	1.243068e-51	7.488359e-54	3.596088e+0	BAK1,GZMB,PMAIP1,YWHAE	MammalianAncestor	50.9055
GO.Biological.Process	GO:0002688	regulation.of.leukocyte.chemotaxis	167	1.019611e-55	1.317032e-51	7.886416e-54	2.431956e+0	CXCL12,CXCL17,FPR2,LBP,SERPINE1,SLAMF1,TNFSF18	MammalianAncestor	50.8804
GO.Biological.Process	GO:0006690	icosanoid.metabolic.process	168	1.541368e-55	1.990985e-51	1.185110e-53	2.703295e+0	ABHD16A,AKR1C2,AKR1C3,ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,ALOXE3,CYP1B1,CYP2E1,CYP4F12,CYP4F2,CYP4F22,CYP4F3,CYP4F8,EPHX2,FAAH2,FCER1A,GGT1,GGT2,GGT6,GGTLC1,GGTLC2,PLA2G4C	MammalianAncestor	50.7009
GO.Biological.Process	GO:0016132	brassinosteroid.biosynthetic.process	169	2.499815e-55	3.229011e-51	1.910657e-53	1.504587e+1	DHCR7	MammalianAncestor	50.4909
GO.Biological.Process	GO:0002252	immune.effector.process	170	4.183751e-55	5.404151e-51	3.178912e-53	1.464985e+0	ACTR1B,AIRE,ALOX5,ARMC8,ASAH1,ATP8B4,B2M,BRK1,BTN3A2,BTN3A3,CAMP,CD177,CD207,CD244,CD86,CEACAM1,CEACAM3,CEACAM6,CEACAM8,CHRNB4,CLU,CRP,CST3,CTSB,CTSG,CTSH,CX3CR1,DBNL,DEFA1,DEFA3,DEFA4,DLG1,ENSG00000259680,FCGR1A,FCGR2A,FCGR2B,FCGR3A,FCGR3B,FPR1,FPR2,GLA,GZMB,HGSNAT,HSPA1A,HSPA1B,HSPA6,IFI16,IGLL5,IL4R,IMPDH1,IQGAP1,ITGAL,ITGB2,KCMF1,KDM5D,LAT,LBP,LILRB2,LILRB3,LIMK1,LTF,LY9,MAVS,MGAM,MICB,MNDA,MRGPRX2,MYO1G,NCK1,NEU1,NLRP3,NLRP9,OAS1,OAS2,OAS3,ORM1,ORM2,OSCAR,PFKL,PIK3CB,PLAUR,PMAIP1,PNP,POLR3K,PPIA,PRDX6,QPCT,RAB7A,RAB9B,RELB,RNASE2,RNASE3,RNASE6,RNF8,ROCK1,SCART1,SERINC5,SERPINB6,SERPINB9,SFTPA1,SIGLEC14,SIGLEC5,SIGLEC9,SLAMF1,SLAMF6,SLAMF7,SLC27A2,SNAP29,STK10,TARM1,TMEM179B,TNFSF18,TRIM11,TRIM56,TSPAN14,TYROBP,VAMP7,WAS,ZMYND11,ZNF175	MammalianAncestor	50.2673
GO.Biological.Process	GO:0008626	granzyme-mediated.apoptotic.signaling.pathway	171	4.709692e-55	6.083509e-51	3.557608e-53	1.097662e+1	GZMB	MammalianAncestor	50.2158
GO.Biological.Process	GO:0006751	glutathione.catabolic.process	172	1.116359e-54	1.442001e-50	8.383726e-53	6.057523e+0	GGT1,GGT2,GGT6,GGTLC1,GGTLC2	MammalianAncestor	49.841
GO.Biological.Process	GO:0010950	positive.regulation.of.endopeptidase.activity	173	1.676734e-54	2.165837e-50	1.251929e-52	2.153133e+0	AIM2,ALOX12,ANP32B,BAK1,BEX3,CARD8,CTSH,FASLG,FIS1,HIP1,IFI16,MAPT,NGF,NLRP1,NLRP12,NLRP3,PDCD6,PMAIP1,RACK1,REST,RIPK1,XDH	MammalianAncestor	49.6644
GO.Biological.Process	GO:0034021	response.to.silicon.dioxide	174	1.713953e-54	2.213913e-50	1.272364e-52	2.249782e+1	SCGB1A1	MammalianAncestor	49.6548
GO.Biological.Process	GO:1902667	regulation.of.axon.guidance	175	1.966367e-54	2.539956e-50	1.451404e-52	2.802661e+0	CXCL12,PLXNA1	MammalianAncestor	49.5952
GO.Biological.Process	GO:2000320	negative.regulation.of.T-helper.17.cell.differentiation	176	1.987490e-54	2.567241e-50	1.458660e-52	7.778891e+0	TNFSF18	MammalianAncestor	49.5905
GO.Biological.Process	GO:0042448	progesterone.metabolic.process	177	4.032777e-54	5.209138e-50	2.943016e-52	7.423498e+0	AKR1C1,AKR1C2,AKR1C3,SRD5A2	MammalianAncestor	49.2832
GO.Biological.Process	GO:0005989	lactose.biosynthetic.process	178	5.014385e-54	6.477081e-50	3.638810e-52	1.563305e+1	SLC2A1	MammalianAncestor	49.1886
GO.Biological.Process	GO:2000252	negative.regulation.of.feeding.behavior	179	5.814092e-54	7.510063e-50	4.195566e-52	6.381467e+0	MC4R,TRH	MammalianAncestor	49.1244
GO.Biological.Process	GO:0046456	icosanoid.biosynthetic.process	180	5.882744e-54	7.598740e-50	4.221522e-52	3.516405e+0	AKR1C3,ALOX12,ALOX15,ALOX5,FCER1A,GGT1,GGT2,GGT6,GGTLC1,GGTLC2	MammalianAncestor	49.1193
GO.Biological.Process	GO:0050974	detection.of.mechanical.stimulus.involved.in.sensory.perception	181	6.815726e-54	8.803873e-50	4.864018e-52	3.235262e+0	CXCL12,TMC2	MammalianAncestor	49.0553
GO.Biological.Process	GO:1900740	positive.regulation.of.protein.insertion.into.mitochondrial.membrane.involved.in.apoptotic.signaling.pathway	182	7.443370e-54	9.614601e-50	5.282748e-52	3.726216e+0	GZMB,PMAIP1,YWHAE	MammalianAncestor	49.0171
GO.Biological.Process	GO:1901186	positive.regulation.of.ERBB.signaling.pathway	183	1.041445e-53	1.345235e-49	7.351008e-52	3.553525e+0	ADRA2B,FASLG,HIP1,PLAUR,TGFA	MammalianAncestor	48.8712
GO.Biological.Process	GO:0052548	regulation.of.endopeptidase.activity	184	1.075457e-53	1.389168e-49	7.549825e-52	1.682967e+0	AIM2,ALOX12,AMBP,ANP32B,ANXA8,BAK1,BEX3,CARD8,COL28A1,CRIM1,CSN2,CST1,CST11,CST2,CST3,CST4,CST5,CST7,CST8,CST9,CST9L,CSTL1,CTSH,ENSG00000267748,FASLG,FIS1,FURIN,HIP1,IFI16,LTF,MAGEA3,MAPT,NGF,NLRP1,NLRP12,NLRP3,OPRPN,PAK2,PAX2,PCSK1N,PDCD6,PLAUR,PMAIP1,RACK1,REST,RIPK1,SERPINB6,SERPINB8,SERPINB9,SERPIND1,SERPINE1,SPINK2,SPINK8,SPINT2,USP14,WNT9A,XDH,YWHAE	MammalianAncestor	48.8572
GO.Biological.Process	GO:0044341	sodium-dependent.phosphate.transport	185	1.227925e-53	1.586111e-49	8.573571e-52	1.191831e+1	SLC17A1,SLC20A1,SLC20A2	MammalianAncestor	48.7997
GO.Biological.Process	GO:0002215	defense.response.to.nematode	186	2.507645e-53	3.239125e-49	1.741465e-51	1.843968e+1	TNFSF4	MammalianAncestor	48.4896
GO.Biological.Process	GO:0016129	phytosteroid.biosynthetic.process	187	3.897202e-53	5.034016e-49	2.691987e-51	1.256740e+1	DHCR7,FDFT1	MammalianAncestor	48.2981
GO.Biological.Process	GO:0030644	cellular.chloride.ion.homeostasis	188	5.028888e-53	6.495815e-49	3.455221e-51	1.142488e+1	FASLG	MammalianAncestor	48.1874
GO.Biological.Process	GO:0010890	positive.regulation.of.sequestering.of.triglyceride	189	6.309414e-53	8.149870e-49	4.312101e-51	1.008237e+1	APOC4,LPL,OSBPL11	MammalianAncestor	48.0888
GO.Biological.Process	GO:0008637	apoptotic.mitochondrial.changes	190	6.489300e-53	8.382229e-49	4.411699e-51	2.927373e+0	ATG3,BAK1,CLU,FIS1,HK2,MTRNR2L5,PMAIP1	MammalianAncestor	48.0766
GO.Biological.Process	GO:0008202	steroid.metabolic.process	191	1.166191e-52	1.506369e-48	7.886748e-51	1.920981e+0	AKR1B1,AKR1C1,AKR1C2,AKR1C3,AKR1C4,APOA2,APOC1,BAAT,CYP1B1,CYP2E1,CYP3A4,CYP3A5,CYP3A7,CYP3A7-CYP3A51P,DHCR7,EBP,FDFT1,HMGCS2,HSD17B7,HSD3B1,HSD3B2,LIPE,NSDHL,SLC27A2,SRD5A2,SULT1A3,SULT1A4,SULT1B1,SULT1E1,SULT2A1,SULT2B1,TNFSF4,UGT2B15,UGT2B17	MammalianAncestor	47.8221
GO.Biological.Process	GO:1902237	positive.regulation.of.endoplasmic.reticulum.stress-induced.intrinsic.apoptotic.signaling.pathway	192	1.668678e-52	2.155431e-48	1.122621e-50	5.622321e+0	NCK1,PMAIP1	MammalianAncestor	47.6665
GO.Biological.Process	GO:0010759	positive.regulation.of.macrophage.chemotaxis	193	1.984020e-52	2.562759e-48	1.327854e-50	4.955592e+0	CXCL17,SLAMF1,TNFSF18	MammalianAncestor	47.5913
GO.Biological.Process	GO:0002826	negative.regulation.of.T-helper.1.type.immune.response	194	2.136545e-52	2.759775e-48	1.422565e-50	9.736767e+0	IL4R,TNFSF4	MammalianAncestor	47.5591
GO.Biological.Process	GO:0045623	negative.regulation.of.T-helper.cell.differentiation	195	2.359270e-52	3.047469e-48	1.562805e-50	4.390082e+0	IL4R,TNFSF18,TNFSF4	MammalianAncestor	47.5161
GO.Biological.Process	GO:1905523	positive.regulation.of.macrophage.migration	196	5.092206e-52	6.577602e-48	3.355920e-50	4.915225e+0	CXCL17,SLAMF1,TNFSF18	MammalianAncestor	47.1819
GO.Biological.Process	GO:2000098	negative.regulation.of.smooth.muscle.cell-matrix.adhesion	197	5.172304e-52	6.681065e-48	3.391404e-50	3.053502e+1	APOD,SERPINE1	MammalianAncestor	47.1752
GO.Biological.Process	GO:0045663	positive.regulation.of.myoblast.differentiation	198	5.470736e-52	7.066550e-48	3.568964e-50	3.677277e+0	IGFBP3	MammalianAncestor	47.1508
GO.Biological.Process	GO:0044806	G-quadruplex.DNA.unwinding	199	5.832180e-52	7.533427e-48	3.785642e-50	7.489341e+0	BLM,WRN	MammalianAncestor	47.123
GO.Biological.Process	GO:0001909	leukocyte.mediated.cytotoxicity	200	8.541354e-52	1.103287e-47	5.516433e-50	4.998351e+0	CTSG,CTSH,GZMB,MICB,SLAMF7,VAMP7	MammalianAncestor	46.9573
GO.Biological.Process	GO:1902533	positive.regulation.of.intracellular.signal.transduction	201	8.642827e-52	1.116394e-47	5.554199e-50	1.342925e+0	ADORA2B,ADRA1A,ADRA2B,AKAP13,AKR1B1,AKR1C2,AKR1C3,ALKAL2,ALOX12B,ALOX15,ARAF,ARHGEF5,CCL24,CCL25,CCL26,CD86,CHP2,CHRNA7,CRKL,CSPG4,CXCL17,CYP1B1,DBNL,DUSP22,EGFR,ERCC6,ERN2,FAM110C,FASLG,FBXO18,FCER1A,FCGR2B,FCRL3,FGF7,FIS1,FLT4,FPR1,FPR2,GHRL,GOLPH3,GPR35,GPR89A,HCLS1,HCST,HINT1,HIP1,HSPA1A,HSPA1B,HTR2C,IGFBP3,IL11,INAVA,INSR,IQGAP1,IRAK2,LPAR1,LPAR4,LRRK2,LTF,MAGED1,MAP2K4,MAP2K7,MAP3K2,MAP4K3,MAVS,MID2,MUC20,NCK1,NGF,NLRP12,NOS1AP,NQO2,NRG1,PARP14,PDE8A,PIK3AP1,PIK3CB,PLXNB1,PMAIP1,PRKCB,PYHIN1,RACK1,RAMP3,RASGEF1A,RASSF2,RIPK1,RPL26,RRAGB,S100B,SCIMP,SEC13,SEMA4C,SHISA5,SLAMF1,SLC20A1,STK26,TDGF1,TGFA,TGFBR1,TNFSF18,TRIM15,UBD,UBE3A,UNC5CL,USP17L2,VANGL2,WNT7A,XDH,ZAP70,ZDHHC13	MammalianAncestor	46.9522
GO.Biological.Process	GO:0097091	synaptic.vesicle.clustering	202	9.274007e-52	1.197923e-47	5.930314e-50	6.991262e+0	SYNDIG1	MammalianAncestor	46.9216
GO.Biological.Process	GO:0048478	replication.fork.protection	203	1.438808e-51	1.858508e-47	9.155213e-50	9.006416e+0	BLM,FBXO18	MammalianAncestor	46.7308
GO.Biological.Process	GO:0008064	regulation.of.actin.polymerization.or.depolymerization	204	1.500617e-51	1.938347e-47	9.501701e-50	2.021194e+0	ADD2,ALOX15,BRK1,CCL24,CCL26,CDC42EP3,CXCL12,DLG1,FHOD3,HCLS1,KIRREL1,MAGEL2,MYADM,NCK1,TMOD1,TMSB4Y,TRIM27,WAS,WASHC1,WASHC2C	MammalianAncestor	46.7126
GO.Biological.Process	GO:2000319	regulation.of.T-helper.17.cell.differentiation	205	2.368324e-51	3.059164e-47	1.492275e-49	5.891444e+0	NLRP3,TNFSF18	MammalianAncestor	46.5144
GO.Biological.Process	GO:0010832	negative.regulation.of.myotube.differentiation	206	2.542505e-51	3.284154e-47	1.594249e-49	4.846929e+0	CEACAM5,HDAC4,MYOCD	MammalianAncestor	46.4836
GO.Biological.Process	GO:0019087	transformation.of.host.cell.by.virus	207	3.562461e-51	4.601631e-47	2.223010e-49	2.027087e+1	INSR	MammalianAncestor	46.3371
GO.Biological.Process	GO:0031100	animal.organ.regeneration	208	3.994499e-51	5.159694e-47	2.480622e-49	2.363994e+0	APOA2,BAAT,BAK1,CXCL12,EGFR,PFKFB1,PRPS1,PTPN3,RGN	MammalianAncestor	46.2874
GO.Biological.Process	GO:2000116	regulation.of.cysteine-type.endopeptidase.activity	209	4.051844e-51	5.233767e-47	2.504195e-49	1.820626e+0	AIM2,ALOX12,ANP32B,BAK1,BEX3,CARD8,CSN2,CST1,CST11,CST2,CST3,CST4,CST5,CST7,CST8,CST9,CST9L,CSTL1,CTSH,FASLG,FIS1,HIP1,IFI16,LTF,MAGEA3,MAPT,NGF,NLRP1,NLRP12,NLRP3,PAK2,PAX2,PDCD6,PLAUR,PMAIP1,RACK1,REST,RIPK1,SERPINB9,WNT9A,XDH,YWHAE	MammalianAncestor	46.2812
GO.Biological.Process	GO:0009100	glycoprotein.metabolic.process	210	6.562095e-51	8.476258e-47	4.036313e-49	1.536960e+0	A4GNT,ADAMTS7,ALG10,ALG10B,ALG1L,ALG1L2,ASGR1,ASGR2,B3GAT1,B4GAT1,C1GALT1,CHST13,CHST7,CHSY3,CSGALNACT1,CSGALNACT2,CSPG4,DAD1,FUT10,GALNT1,GALNT12,GOLPH3,GPC1,HS6ST1,MGAT1,MUC12,MUC16,MUC17,MUC20,MUC21,MUC4,MUC7,NEU4,OAS2,PARP14,PCSK6,PLOD3,POMK,PORCN,PXYLP1,RPN2,SDF2L1,SPON1,TNKS,VANGL2,XYLT2	MammalianAncestor	46.0718
GO.Biological.Process	GO:0015931	nucleobase-containing.compound.transport	211	8.732899e-51	1.128029e-46	5.346107e-49	1.958175e+0	AHCTF1,ATP6V1G2-DDX39B,EIF5AL1,NCBP2,NPAP1,NUP205,NUP88,NXF2,NXF2B,NXF3,NXF5,POM121L12,POM121L2,RBMX2,SEC13,SLC25A36,SLC28A1,SLC28A2,SLC29A2,SLC35B4,TNKS	MammalianAncestor	45.9477
GO.Biological.Process	GO:0048295	positive.regulation.of.isotype.switching.to.IgE.isotypes	212	9.861612e-51	1.273824e-46	6.008606e-49	1.659363e+1	TNFSF4	MammalianAncestor	45.8949
GO.Biological.Process	GO:0050829	defense.response.to.Gram-negative.bacterium	213	1.033050e-50	1.334391e-46	6.264745e-49	3.039898e+0	CD160,CST11,CTSG,DEFA4,DEFA5,DEFB1,DEFB103A,DEFB103B,DEFB126,DEFB127,DEFB128,DEFB132,DEFB4A,DEFB4B,HIST1H2BJ,HIST1H2BK,LBP,LTF,LYPD8,RNASE3,RNASE6,RNASE7,RNASE8,RPS19,SERPINE1,SPACA4,SPACA5,SPACA5B	MammalianAncestor	45.8747
GO.Biological.Process	GO:0043371	negative.regulation.of.CD4-positive,.alpha-beta.T.cell.differentiation	214	1.591864e-50	2.056211e-46	9.608461e-49	4.245514e+0	IL4R,TNFSF18,TNFSF4	MammalianAncestor	45.6869
GO.Biological.Process	GO:0030832	regulation.of.actin.filament.length	215	2.629305e-50	3.396273e-46	1.579662e-48	2.001171e+0	ADD2,ALOX15,BRK1,CCL24,CCL26,CDC42EP3,CXCL12,DLG1,FHOD3,HCLS1,KIRREL1,MAGEL2,MYADM,NCK1,TMOD1,TMSB4Y,TRIM27,WAS,WASHC1,WASHC2C	MammalianAncestor	45.469
GO.Biological.Process	GO:0007161	calcium-independent.cell-matrix.adhesion	216	2.975201e-50	3.843067e-46	1.779198e-48	7.347913e+0	FN1	MammalianAncestor	45.4153
GO.Biological.Process	GO:2000525	positive.regulation.of.T.cell.costimulation	217	5.019213e-50	6.483317e-46	2.987704e-48	1.612177e+1	TNFSF4	MammalianAncestor	45.1882
GO.Biological.Process	GO:0002260	lymphocyte.homeostasis	218	5.950689e-50	7.686505e-46	3.525920e-48	2.993187e+0	BAK1,IL2RA,LAT,PMAIP1,SLC46A2,TNFRSF13B	MammalianAncestor	45.1143
GO.Biological.Process	GO:1902108	regulation.of.mitochondrial.membrane.permeability.involved.in.apoptotic.process	219	6.074836e-50	7.846866e-46	3.583044e-48	3.930261e+0	MTRNR2L5,PMAIP1	MammalianAncestor	45.1053
GO.Biological.Process	GO:0006082	organic.acid.metabolic.process	220	8.020713e-50	1.036035e-45	4.709252e-48	1.381278e+0	AARS2,ABHD16A,ACAD9,ACADVL,AKR1C1,AKR1C2,AKR1C3,AKR1C4,ALDH18A1,ALDH1L1,ALDH3A2,ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,ALOXE3,ASNS,ASRGL1,B3GAT1,B4GAT1,BAAT,CBSL,CHST13,CHST7,CHSY3,CROT,CSGALNACT1,CSGALNACT2,CSPG4,CYP1B1,CYP2E1,CYP4F11,CYP4F12,CYP4F2,CYP4F22,CYP4F3,CYP4F8,DDAH2,ENSG00000277669,EPHX2,FAAH2,FCER1A,GATM,GGT1,GGT2,GGT6,GGTLC1,GGTLC2,GLUD1,GPC1,HK2,HS6ST1,IDH3B,LIPE,LPL,MAT1A,MINPP1,MSRA,MTHFD2,MTHFS,MUT,NANP,NDUFAB1,OLAH,PANK2,PC,PECR,PFAS,PFKFB1,PFKL,PGK1,PHGDH,PLA2G4C,PLOD3,PNP,PRKAB2,PRODH,PRPS1,PXYLP1,QPRT,RGN,RIMKLA,SDHA,SDHC,SEPHS2,SERINC5,SLC17A1,SLC17A3,SLC27A2,SLC2A1,SLC7A4,SORD,SRD5A2,SUCLG1,SULT1A3,SULT1A4,SULT1B1,SULT1E1,SULT2A1,SULT2B1,TARSL2,UGT2A1,UGT2A2,UGT2A3,UGT2B15,UGT2B17,UGT2B4,UGT2B7,UROC1,VANGL2,VARS,VARS2,XYLB,XYLT2	MammalianAncestor	44.9846
GO.Biological.Process	GO:0002227	innate.immune.response.in.mucosa	221	1.396159e-49	1.803419e-45	8.160265e-48	6.940760e+0	CAMP,DEFA1,DEFA3,DEFB1,HIST1H2BJ,HIST1H2BK,LTF,RNASE3	MammalianAncestor	44.7439
GO.Biological.Process	GO:0019233	sensory.perception.of.pain	222	1.803257e-49	2.329267e-45	1.049219e-47	2.257142e+0	ALOXE3,CXCL12,MRGPRX2,NDN,POMK,TACR1	MammalianAncestor	44.6328
GO.Biological.Process	GO:0060267	positive.regulation.of.respiratory.burst	223	1.922874e-49	2.483776e-45	1.113801e-47	9.217667e+0	INSR,JCHAIN,LBP,RPS19	MammalianAncestor	44.6049
GO.Biological.Process	GO:0032535	regulation.of.cellular.component.size	224	2.204903e-49	2.848073e-45	1.271461e-47	1.599502e+0	ADD2,ALOX15,ANXA7,BRK1,CCL24,CCL26,CDC42EP3,CXCL12,DLG1,FHOD3,FN1,FSTL4,HCLS1,KCNN4,KDM1A,KIRREL1,LIMK1,MAGEL2,MAPT,MYADM,NCK1,NRCAM,NRG1,PEX11G,PLXNA1,PRR16,SEMA4F,TMOD1,TMSB4Y,TRIM27,TRPV2,WAS,WASHC1,WASHC2C,WNT7A	MammalianAncestor	44.5454
GO.Biological.Process	GO:0032689	negative.regulation.of.interferon-gamma.production	225	2.959149e-49	3.822333e-45	1.698815e-47	3.323622e+0	IL20RB,PRNP,SCGB1A1,SLAMF1,TNFSF4	MammalianAncestor	44.4177
GO.Biological.Process	GO:0070376	regulation.of.ERK5.cascade	226	3.063516e-49	3.957144e-45	1.750949e-47	1.343178e+1	ALKAL2,MAPK7	MammalianAncestor	44.4026
GO.Biological.Process	GO:0051250	negative.regulation.of.lymphocyte.activation	227	3.931687e-49	5.078560e-45	2.237251e-47	2.047948e+0	BTN2A2,CEACAM1,DLG1,DTX1,DUSP22,FCGR2B,HLA-G,HMGB3,IL20RB,IL2RA,IL4R,LILRB2,MNDA,NFKBID,PRNP,RHBDD3,SCGB1A1,SFTPD,SPN,TARM1,TNFRSF13B,TNFSF18,TNFSF4	MammalianAncestor	44.2943
GO.Biological.Process	GO:0001706	endoderm.formation	228	6.547885e-49	8.457903e-45	3.709607e-47	2.391334e+0	DUSP1,DUSP4,FN1,HNF1B,ITGB2,LAMB1,POU5F1	MammalianAncestor	44.0727
GO.Biological.Process	GO:0060333	interferon-gamma-mediated.signaling.pathway	229	1.619225e-48	2.091553e-44	9.133419e-47	2.950358e+0	B2M,FCGR1A,FCGR1B,HLA-B,HLA-DQA1,HLA-DQA2,HLA-DQB2,HLA-DRA,HLA-DRB1,HLA-DRB5,HLA-F,HLA-G,IRF6,OAS1,OAS2,OAS3,TRIM26,TRIM31	MammalianAncestor	43.6795
GO.Biological.Process	GO:0043410	positive.regulation.of.MAPK.cascade	230	1.894409e-48	2.447008e-44	1.063917e-46	1.444765e+0	ADORA2B,ADRA1A,ADRA2B,AKAP13,ALKAL2,ALOX12B,ALOX15,ARAF,ARHGEF5,CCL24,CCL25,CCL26,CHRNA7,CRKL,CSPG4,CXCL17,DBNL,DUSP22,EGFR,ERCC6,ERN2,FCER1A,FCGR2B,FCRL3,FLT4,FPR1,FPR2,GHRL,HTR2C,IGFBP3,IL11,INAVA,INSR,IQGAP1,IRAK2,LPAR1,LRRK2,MAGED1,MAP2K4,MAP2K7,MAP3K2,MAP4K3,MUC20,NGF,NQO2,NRG1,PDE8A,PIK3CB,RAMP3,RASSF2,RIPK1,SCIMP,SEMA4C,SLAMF1,STK26,TDGF1,TGFA,TGFBR1,UNC5CL,VANGL2,WNT7A,XDH	MammalianAncestor	43.6114
GO.Biological.Process	GO:0032902	nerve.growth.factor.production	231	2.231697e-48	2.882683e-44	1.247915e-46	1.666162e+1	FURIN,PCSK6	MammalianAncestor	43.5402
GO.Biological.Process	GO:1901661	quinone.metabolic.process	232	8.187599e-48	1.057592e-43	4.558587e-46	4.269044e+0	AKR1B1,AKR1C1,AKR1C2,AKR1C3,AKR1C4,CYP4F11,CYP4F2,VKORC1L1	MammalianAncestor	42.9757
GO.Biological.Process	GO:0003016	respiratory.system.process	233	8.574700e-48	1.107594e-43	4.753622e-46	5.628644e+0	CCBE1,FLT4,NDN	MammalianAncestor	42.9556
GO.Biological.Process	GO:2001303	lipoxin.A4.biosynthetic.process	234	1.178802e-47	1.522659e-43	6.507088e-46	2.330258e+1	ALOX12,ALOX15	MammalianAncestor	42.8174
GO.Biological.Process	GO:0010676	positive.regulation.of.cellular.carbohydrate.metabolic.process	235	1.253559e-47	1.619222e-43	6.890307e-46	2.610383e+0	ACTN3,CD244,DUSP12,INSR,PFKFB1,PMAIP1,POU1F1,RGN,SORBS1	MammalianAncestor	42.7907
GO.Biological.Process	GO:1901028	regulation.of.mitochondrial.outer.membrane.permeabilization.involved.in.apoptotic.signaling.pathway	236	1.273134e-47	1.644507e-43	6.968251e-46	3.159872e+0	BAK1,GZMB,HSPA1A,PMAIP1,YWHAE	MammalianAncestor	42.784
GO.Biological.Process	GO:0032981	mitochondrial.respiratory.chain.complex.I.assembly	237	2.255563e-47	2.913511e-43	1.229329e-45	3.402344e+0	ACAD9,COA1,DMAC2,NDUFA10,NDUFAB1,NDUFB11,OXA1L	MammalianAncestor	42.5356
GO.Biological.Process	GO:0097527	necroptotic.signaling.pathway	238	2.671515e-47	3.450796e-43	1.449914e-45	9.098605e+0	FASLG,RIPK1	MammalianAncestor	42.4621
GO.Biological.Process	GO:1903037	regulation.of.leukocyte.cell-cell.adhesion	239	2.688850e-47	3.473188e-43	1.453217e-45	1.600153e+0	BTLA,BTN2A2,CCL25,CD1D,CD244,CD86,CEACAM1,CLPTM1,CXCL12,DLG1,DTX1,DUSP22,FANCD2,FCGR2B,HLA-DQA1,HLA-DQA2,HLA-DQB2,HLA-DRA,HLA-DRB1,HLA-DRB5,HLA-G,ICOSLG,IL20RB,IL2RA,IL4R,KIRREL1,LAT,LILRB2,NCK1,NFKBID,NLRP3,PAK2,PDCD1,PNP,PRNP,SCGB1A1,SFTPD,SLAMF1,SLC46A2,SPN,TARM1,TNFSF18,TNFSF4,ZAP70	MammalianAncestor	42.4593
GO.Biological.Process	GO:0086103	G-protein.coupled.receptor.signaling.pathway.involved.in.heart.process	240	3.175575e-47	4.101890e-43	1.709121e-45	4.580407e+0	AKAP13,RAMP3	MammalianAncestor	42.387
GO.Biological.Process	GO:0055064	chloride.ion.homeostasis	241	4.963192e-47	6.410955e-43	2.660147e-45	9.371803e+0	FASLG	MammalianAncestor	42.1931
GO.Biological.Process	GO:0051204	protein.insertion.into.mitochondrial.membrane	242	5.897961e-47	7.618396e-43	3.148098e-45	5.913861e+0	PMAIP1	MammalianAncestor	42.1181
GO.Biological.Process	GO:0042997	negative.regulation.of.Golgi.to.plasma.membrane.protein.transport	243	1.139238e-46	1.471554e-42	6.055777e-45	8.750420e+0	PKDCC	MammalianAncestor	41.8322
GO.Biological.Process	GO:0032897	negative.regulation.of.viral.transcription	244	1.530389e-46	1.976803e-42	8.101654e-45	4.237756e+0	MID2,REST,TRIM11,TRIM14,TRIM27,TRIM31	MammalianAncestor	41.704
GO.Biological.Process	GO:0055114	oxidation-reduction.process	245	1.534067e-46	1.981554e-42	8.087977e-45	1.380242e+0	AAED1,ACAD9,ACADVL,AIFM3,AKR1B1,AKR1C1,AKR1C2,AKR1C3,AKR1C4,AKR1E2,ALDH18A1,ALDH1L1,ALDH3A2,ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,ALOXE3,APOA2,BDH1,BLVRA,C20orf96,CCS,CHCHD4,CHCHD5,COX5B,COX6B1,COX7A1,CROT,CYP1B1,CYP2E1,CYP3A4,CYP3A43,CYP3A5,CYP3A7,CYP3A7-CYP3A51P,CYP4F11,CYP4F12,CYP4F2,CYP4F22,CYP4F3,CYP4F8,DHCR7,DHRS7C,DUOX1,DUOX2,ENOX2,FAM213A,FAR1,FAR2,FDFT1,FMO5,FTMT,GLUD1,GPX5,GPX6,GSR,HK2,HSD17B7,HSD3B1,HSD3B2,IDH3B,IMPDH1,KDM1A,KDM5D,KDM7A,KDM8,LYRM7,MC4R,MSRA,MTHFD2,NDUFA10,NDUFAB1,NDUFB11,NLRP11,NQO2,NSDHL,OXA1L,PANK2,PAX2,PDIA4,PECR,PFKL,PGK1,PHGDH,PLOD3,PPP1R2,PRDX6,PRODH,SCCPDH,SDHA,SDHC,SDR39U1,SH3PXD2B,SLC27A2,SORD,SQOR,SRD5A2,SUCLG1,TBRG4,TMLHE,TPO,TXNRD3,TYW1,UQCRFS1,VKORC1L1,XDH	MammalianAncestor	41.703
GO.Biological.Process	GO:0033559	unsaturated.fatty.acid.metabolic.process	246	1.665869e-46	2.151803e-42	8.747167e-45	2.443630e+0	ABHD16A,AKR1C2,AKR1C3,ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,ALOXE3,CYP1B1,CYP2E1,CYP4F12,CYP4F2,CYP4F3,CYP4F8,EPHX2,FAAH2,FCER1A,GGT1,GGT2,GGT6,GGTLC1,GGTLC2,PLA2G4C	MammalianAncestor	41.6672
GO.Biological.Process	GO:0019835	cytolysis	247	1.786508e-46	2.307632e-42	9.342641e-45	4.257543e+0	BAK1,GZMB,GZMH,MICB,REG3G	MammalianAncestor	41.6368
GO.Biological.Process	GO:0002443	leukocyte.mediated.immunity	248	3.062142e-46	3.955369e-42	1.594907e-44	1.533451e+0	ACTR1B,AIRE,ALOX5,ARMC8,ASAH1,ATP8B4,B2M,BTN3A2,BTN3A3,CAMP,CD177,CEACAM1,CEACAM3,CEACAM6,CEACAM8,CHRNB4,CLU,CST3,CTSB,CTSG,CTSH,DBNL,DEFA1,DEFA4,DLG1,ENSG00000259680,FCGR2A,FCGR2B,FCGR3B,FPR1,FPR2,GLA,GZMB,HGSNAT,HSPA1A,HSPA1B,HSPA6,IGLL5,IL4R,IMPDH1,IQGAP1,ITGAL,ITGB2,KCMF1,KDM5D,LAT,LILRB2,LILRB3,LTF,MGAM,MICB,MNDA,MRGPRX2,MYO1G,NEU1,ORM1,ORM2,OSCAR,PFKL,PLAUR,PNP,PPIA,PRDX6,QPCT,RAB7A,RAB9B,RNASE2,RNASE3,RNF8,ROCK1,SCART1,SERPINB6,SERPINB9,SIGLEC14,SIGLEC5,SIGLEC9,SLAMF1,SLAMF7,SLC27A2,SNAP29,STK10,TARM1,TMEM179B,TSPAN14,TYROBP,VAMP7	MammalianAncestor	41.4028
GO.Biological.Process	GO:0008361	regulation.of.cell.size	249	3.354243e-46	4.332676e-42	1.740030e-44	1.766151e+0	ANXA7,CXCL12,FN1,FSTL4,KCNN4,KDM1A,LIMK1,MAPT,NRCAM,NRG1,PLXNA1,PRR16,SEMA4F,TRPV2	MammalianAncestor	41.3632
GO.Biological.Process	GO:2001021	negative.regulation.of.response.to.DNA.damage.stimulus	250	4.296321e-46	5.549558e-42	2.219823e-44	2.645910e+0	ATP6V1G2-DDX39B,CLU,CXCL12,FBXO18,KDM1A,POLQ,PTTG1IP,TAF9B	MammalianAncestor	41.2557
GO.Biological.Process	GO:1902903	regulation.of.supramolecular.fiber.organization	251	5.336572e-46	6.893250e-42	2.746315e-44	1.641457e+0	ADD2,AKAP13,ALMS1,ALOX15,ARHGEF15,ARHGEF5,BRK1,CAMSAP2,CCL24,CCL26,CDC42EP3,CXCL12,DLG1,FHOD3,HCLS1,HDAC6,HSPA1A,HSPA1B,KIRREL1,LIMK1,LPAR1,MAGEL2,MAPT,MYADM,NCK1,ROCK1,SH3PXD2B,TACR1,TGFBR1,TMOD1,TMSB4Y,TRIM27,WAS,WASHC1,WASHC2C	MammalianAncestor	41.1616
GO.Biological.Process	GO:0007162	negative.regulation.of.cell.adhesion	252	6.854215e-46	8.853590e-42	3.513329e-44	1.665756e+0	ALOX12,APOD,BTN2A2,CCL25,CEACAM1,COL1A1,CXCL12,CYP1B1,DLG1,DTX1,DUSP22,EPB41L5,FCGR2B,FXYD5,HLA-G,IL20RB,IL2RA,IL4R,LILRB2,MAPK7,MUC21,MYADM,NFKBID,PLXNB1,PLXND1,PRNP,SCGB1A1,SERPINE1,SFTPD,SPINT2,SPN,TARM1,TNFSF18,TNFSF4	MammalianAncestor	41.0529
GO.Biological.Process	GO:0090280	positive.regulation.of.calcium.ion.import	253	7.287797e-46	9.413647e-42	3.720809e-44	2.602348e+0	CASR,CXCL12,RAMP3,TRPV2	MammalianAncestor	41.0262
GO.Biological.Process	GO:1902093	positive.regulation.of.flagellated.sperm.motility	254	8.889096e-46	1.148205e-41	4.520490e-44	5.217642e+0	DEFB1,RNASE10,RNASE9,TACR1	MammalianAncestor	40.94
GO.Biological.Process	GO:0001818	negative.regulation.of.cytokine.production	255	1.078872e-45	1.393579e-41	5.465016e-44	1.762118e+0	ACP5,APOA2,APOD,BTN2A2,CARD8,CD84,CEACAM1,CHRNA7,CUEDC2,FCGR2B,FN1,FURIN,GHRL,IL20RB,LBP,LTF,MAVS,NDRG2,NFKBIL1,NLRP12,NLRP3,ORM1,PRNP,RELB,RNF216,SCGB1A1,SFTPD,SLAMF1,TNFSF4,TRIM27	MammalianAncestor	40.8559
GO.Biological.Process	GO:0032461	positive.regulation.of.protein.oligomerization	256	1.157005e-45	1.494503e-41	5.837904e-44	3.877301e+0	AIM2,CLU,JCHAIN,PMAIP1,RACK1,TRABD2A	MammalianAncestor	40.8255
GO.Biological.Process	GO:0061387	regulation.of.extent.of.cell.growth	257	1.258532e-45	1.625646e-41	6.325470e-44	1.914528e+0	CXCL12,FN1,FSTL4,LIMK1,MAPT,NRCAM,NRG1,PLXNA1,SEMA4F,TRPV2	MammalianAncestor	40.789
GO.Biological.Process	GO:0002695	negative.regulation.of.leukocyte.activation	258	1.352714e-45	1.747301e-41	6.772483e-44	1.910344e+0	BTN2A2,CD200,CD84,CEACAM1,DLG1,DTX1,DUSP22,FCGR2B,HLA-G,HMGB3,IL20RB,IL2RA,IL4R,LILRB2,MNDA,NFKBID,PRNP,RHBDD3,SCGB1A1,SFTPD,SPN,TARM1,TNFRSF13B,TNFSF18,TNFSF4	MammalianAncestor	40.7576
GO.Biological.Process	GO:0048668	collateral.sprouting	259	2.374713e-45	3.067417e-41	1.184331e-43	3.797011e+0	COBL,HDAC6	MammalianAncestor	40.5132
GO.Biological.Process	GO:0033489	cholesterol.biosynthetic.process.via.desmosterol	260	3.113326e-45	4.021483e-41	1.546724e-43	9.173961e+0	DHCR7,EBP	MammalianAncestor	40.3956
GO.Biological.Process	GO:0033490	cholesterol.biosynthetic.process.via.lathosterol	260	3.113326e-45	4.021483e-41	1.546724e-43	9.173961e+0	DHCR7,EBP	MammalianAncestor	40.3956
GO.Biological.Process	GO:0032956	regulation.of.actin.cytoskeleton.organization	262	4.247120e-45	5.486005e-41	2.093895e-43	1.619606e+0	ADD2,AKAP13,ALMS1,ALOX15,ARHGAP44,ARHGEF15,ARHGEF5,BRK1,CCL24,CCL26,CDC42EP3,CXCL12,DLG1,F11R,FHOD3,FSCN1,HCLS1,KIRREL1,LIMK1,LPAR1,MAGEL2,MYADM,NCK1,ODAM,RHOD,ROCK1,SH3PXD2B,TACR1,TGFBR1,TMOD1,TMSB4Y,TRIM27,VANGL2,WAS,WASHC1,WASHC2C	MammalianAncestor	40.2607
GO.Biological.Process	GO:0050772	positive.regulation.of.axonogenesis	263	9.561944e-45	1.235116e-40	4.696260e-43	2.003401e+0	CXCL12,FN1,LIMK1,MAPT,NGF,NRG1,PLXNB1,PLXND1,ROBO2,TRPV2	MammalianAncestor	39.9083
GO.Biological.Process	GO:0070378	positive.regulation.of.ERK5.cascade	264	2.798926e-44	3.615373e-40	1.369459e-42	1.272303e+1	ALKAL2	MammalianAncestor	39.4418
GO.Biological.Process	GO:2000097	regulation.of.smooth.muscle.cell-matrix.adhesion	265	3.695366e-44	4.773304e-40	1.801247e-42	2.045755e+1	APOD,SERPINE1	MammalianAncestor	39.3212
GO.Biological.Process	GO:0042219	cellular.modified.amino.acid.catabolic.process	266	4.749050e-44	6.134348e-40	2.306146e-42	3.554709e+0	ALDH1L1,GGT1,GGT2,GGT6,GGTLC1,GGTLC2,MTHFS,PRODH	MammalianAncestor	39.2122
GO.Biological.Process	GO:0001836	release.of.cytochrome.c.from.mitochondria	267	7.267789e-44	9.387803e-40	3.516031e-42	4.321956e+0	BAK1,CLU,FIS1,PMAIP1	MammalianAncestor	39.0274
GO.Biological.Process	GO:0051881	regulation.of.mitochondrial.membrane.potential	268	9.639885e-44	1.245184e-39	4.646209e-42	2.786818e+0	ALOX12,BAK1,CLIC1,LRRK2,MAPT,PANK2,PMAIP1,RACK1,SLC25A36	MammalianAncestor	38.9048
GO.Biological.Process	GO:0043436	oxoacid.metabolic.process	269	1.240916e-43	1.602891e-39	5.958703e-42	1.357221e+0	AARS2,ABHD16A,ACAD9,ACADVL,AKR1C1,AKR1C2,AKR1C3,AKR1C4,ALDH18A1,ALDH1L1,ALDH3A2,ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,ALOXE3,ASNS,ASRGL1,B3GAT1,B4GAT1,BAAT,CBSL,CHST13,CHST7,CHSY3,CROT,CSGALNACT1,CSGALNACT2,CSPG4,CYP1B1,CYP2E1,CYP4F11,CYP4F12,CYP4F2,CYP4F22,CYP4F3,CYP4F8,DDAH2,ENSG00000277669,EPHX2,FAAH2,FCER1A,GATM,GGT1,GGT2,GGT6,GGTLC1,GGTLC2,GLUD1,GPC1,HK2,HS6ST1,IDH3B,LIPE,LPL,MAT1A,MINPP1,MSRA,MTHFD2,MTHFS,MUT,NANP,NDUFAB1,OLAH,PANK2,PC,PECR,PFAS,PFKFB1,PFKL,PGK1,PHGDH,PLA2G4C,PLOD3,PRKAB2,PRODH,PXYLP1,QPRT,RGN,RIMKLA,SDHA,SDHC,SEPHS2,SERINC5,SLC27A2,SLC2A1,SLC7A4,SORD,SRD5A2,SUCLG1,SULT1A3,SULT1A4,SULT1B1,SULT1E1,SULT2A1,SULT2B1,TARSL2,UGT2A1,UGT2A2,UGT2A3,UGT2B15,UGT2B17,UGT2B4,UGT2B7,UROC1,VANGL2,VARS,VARS2,XYLB,XYLT2	MammalianAncestor	38.7951
GO.Biological.Process	GO:0090066	regulation.of.anatomical.structure.size	270	1.618719e-43	2.090899e-39	7.744072e-42	1.455227e+0	ADD2,ADORA2B,ADRA1A,ADRA1D,ADRA2B,ALOX15,ANXA7,BRK1,CASR,CCL24,CCL26,CDC42EP3,CHRM1,CXCL12,DLG1,EGFR,FHOD3,FN1,FSTL4,HCLS1,HNF1B,KCNN4,KDM1A,KIRREL1,LIMK1,LRRK2,MAGEL2,MAPT,MYADM,NCK1,NRCAM,NRG1,PAX2,PEX11G,PLOD3,PLXNA1,PRR16,SEMA4F,SLC8A1,TACR1,TMOD1,TMSB4Y,TRIM27,TRPV2,WAS,WASHC1,WASHC2C,WNT7A	MammalianAncestor	38.6797
GO.Biological.Process	GO:0010758	regulation.of.macrophage.chemotaxis	271	1.733738e-43	2.239469e-39	8.263725e-42	4.127340e+0	CXCL17,SLAMF1,TNFSF18	MammalianAncestor	38.6499
GO.Biological.Process	GO:0045907	positive.regulation.of.vasoconstriction	272	3.294874e-43	4.255989e-39	1.564702e-41	3.093043e+0	ADRA1A,ADRA1D,CASR,EGFR,TACR1	MammalianAncestor	38.371
GO.Biological.Process	GO:2000515	negative.regulation.of.CD4-positive,.alpha-beta.T.cell.activation	273	4.281182e-43	5.530003e-39	2.025642e-41	3.673737e+0	IL4R,TARM1,TNFSF18,TNFSF4	MammalianAncestor	38.2573
GO.Biological.Process	GO:0042149	cellular.response.to.glucose.starvation	274	5.570202e-43	7.195030e-39	2.625923e-41	3.176042e+0	ASNS,IFI16,PMAIP1,SLC2A1	MammalianAncestor	38.143
GO.Biological.Process	GO:0090279	regulation.of.calcium.ion.import	275	1.251133e-42	1.616088e-38	5.876685e-41	1.975591e+0	CASR,CLIC2,CXCL12,DHRS7C,FCRL3,PRNP,RAMP3,SLC8A1,TRIM27,TRPV2	MammalianAncestor	37.7915
GO.Biological.Process	GO:0008210	estrogen.metabolic.process	276	2.781695e-42	3.593115e-38	1.301853e-40	4.149321e+0	CYP1B1,HSD17B7,HSD3B1,SULT1E1,UGT2B4	MammalianAncestor	37.4445
GO.Biological.Process	GO:0034418	urate.biosynthetic.process	277	3.729989e-42	4.818027e-38	1.739360e-40	2.239126e+1	PNP,PRPS1	MammalianAncestor	37.3171
GO.Biological.Process	GO:0007588	excretion	278	3.798109e-42	4.906017e-38	1.764754e-40	3.039924e+0	ADORA2B,ADRA1A,CHRNA3,CHRNB4,CLCN5,GUCA2B,KIRREL1,TACR1	MammalianAncestor	37.3093
GO.Biological.Process	GO:1905521	regulation.of.macrophage.migration	279	4.557340e-42	5.886716e-38	2.109934e-40	4.005502e+0	CXCL17,SLAMF1,TNFSF18	MammalianAncestor	37.2301
GO.Biological.Process	GO:0042147	retrograde.transport,.endosome.to.Golgi	280	4.721047e-42	6.098176e-38	2.177920e-40	2.590361e+0	AP1S1,ARL1,EHD3,ENSG00000280433,MAGEL2,RAB6C,RAB7A,RAB9B,RBSN,TBC1D10B,TRIM27,WASHC1,WASHC2A,WASHC2C	MammalianAncestor	37.2148
GO.Biological.Process	GO:0034983	peptidyl-lysine.deacetylation	281	8.218123e-42	1.061535e-37	3.777704e-40	5.686770e+0	HDAC4,HDAC6	MammalianAncestor	36.9741
GO.Biological.Process	GO:0050927	positive.regulation.of.positive.chemotaxis	282	9.894562e-42	1.278081e-37	4.532201e-40	2.780794e+0	CASR,CXCL12	MammalianAncestor	36.8934
GO.Biological.Process	GO:0046351	disaccharide.biosynthetic.process	283	1.227813e-41	1.585966e-37	5.604120e-40	9.772196e+0	SLC2A1	MammalianAncestor	36.7997
GO.Biological.Process	GO:0042796	snRNA.transcription.from.RNA.polymerase.III.promoter	284	1.438323e-41	1.857882e-37	6.541837e-40	6.556906e+0	ICE1	MammalianAncestor	36.731
GO.Biological.Process	GO:0072531	pyrimidine-containing.compound.transmembrane.transport	285	1.469417e-41	1.898046e-37	6.659810e-40	4.791266e+0	SLC25A36,SLC28A1,SLC35B4	MammalianAncestor	36.7217
GO.Biological.Process	GO:0090200	positive.regulation.of.release.of.cytochrome.c.from.mitochondria	286	1.837677e-41	2.373727e-37	8.299746e-40	4.101547e+0	BAK1,PLAUR,PMAIP1	MammalianAncestor	36.6246
GO.Biological.Process	GO:0035106	operant.conditioning	287	1.999944e-41	2.583328e-37	9.001142e-40	7.620055e+0	TACR1	MammalianAncestor	36.5878
GO.Biological.Process	GO:0042996	regulation.of.Golgi.to.plasma.membrane.protein.transport	288	4.122382e-41	5.324881e-37	1.848917e-39	6.649902e+0	PKDCC,RACK1	MammalianAncestor	36.2737
GO.Biological.Process	GO:0045793	positive.regulation.of.cell.size	289	4.495615e-41	5.806986e-37	2.009338e-39	3.944739e+0	KDM1A,PRR16	MammalianAncestor	36.236
GO.Biological.Process	GO:0045590	negative.regulation.of.regulatory.T.cell.differentiation	290	6.170188e-41	7.970032e-37	2.748287e-39	1.106242e+1	TNFSF4	MammalianAncestor	36.0985
GO.Biological.Process	GO:2001243	negative.regulation.of.intrinsic.apoptotic.signaling.pathway	291	7.829297e-41	1.011310e-36	3.475293e-39	2.385249e+0	CLU,CXCL12,HSPA1A,KDM1A,LRRK2,MAGEA3,MAPK7,PLAUR,PTTG1IP,TAF9B	MammalianAncestor	35.9951
GO.Biological.Process	GO:0070837	dehydroascorbic.acid.transport	292	9.513156e-41	1.228814e-36	4.208268e-39	9.440344e+0	SLC2A1	MammalianAncestor	35.9105
GO.Biological.Process	GO:0005984	disaccharide.metabolic.process	293	1.161551e-40	1.500375e-36	5.120735e-39	7.553526e+0	MGAM,SLC2A1	MammalianAncestor	35.8238
GO.Biological.Process	GO:0090656	t-circle.formation	294	1.218849e-40	1.574387e-36	5.355059e-39	5.444527e+0	BLM,SLX1B,WRN	MammalianAncestor	35.8029
GO.Biological.Process	GO:0061370	testosterone.biosynthetic.process	295	1.328604e-40	1.716158e-36	5.817484e-39	7.410195e+0	AKR1C3,SRD5A2	MammalianAncestor	35.7654
GO.Biological.Process	GO:0034629	cellular.protein.complex.localization	296	1.657735e-40	2.141296e-36	7.234109e-39	3.613515e+0	DLG1,EXOC3,EXOC8,GPN1,STXBP6	MammalianAncestor	35.6693
GO.Biological.Process	GO:0002698	negative.regulation.of.immune.effector.process	297	1.935716e-40	2.500364e-36	8.418735e-39	2.210754e+0	APOA2,CD84,CEACAM1,CUEDC2,DUSP22,FCGR2B,FCRL3,IL20RB,IL2RA,IL4R,MICB,RPS19,SERPINB9,SLAMF1,SPN,TNFSF18,TNFSF4	MammalianAncestor	35.602
GO.Biological.Process	GO:0032928	regulation.of.superoxide.anion.generation	298	2.241738e-40	2.895653e-36	9.716956e-39	5.037420e+0	ACP5,CD177,CRP,EGFR,FPR2,ITGB2,MAPT	MammalianAncestor	35.5383
GO.Biological.Process	GO:0050926	regulation.of.positive.chemotaxis	299	3.222123e-40	4.162016e-36	1.391979e-38	2.717799e+0	CASR,CXCL12	MammalianAncestor	35.3807
GO.Biological.Process	GO:0009615	response.to.virus	300	3.447897e-40	4.453649e-36	1.484550e-38	1.818452e+0	AP1S1,CD207,CD86,CLU,CXCL12,DEFA1,DEFA3,DUOX2,IFI16,MAVS,NLRP3,NLRP9,OAS1,OAS2,OAS3,PMAIP1,POLR3K,RNASE2,RNASE6,SERINC5,TNFSF4,TRIM11,TRIM56,ZMYND11,ZNF175	MammalianAncestor	35.3513
GO.Biological.Process	GO:1905477	positive.regulation.of.protein.localization.to.membrane	301	3.530362e-40	4.560169e-36	1.515006e-38	1.985552e+0	DLG1,EGFR,EPHB2,FIS1,GZMB,PDZK1,PMAIP1,PRNP,RACK1,RAMP3,RANGRF,SORBS1,TCAF1,TCAF2,YWHAE	MammalianAncestor	35.341
GO.Biological.Process	GO:0021842	chemorepulsion.involved.in.interneuron.migration.from.the.subpallium.to.the.cortex	302	4.745868e-40	6.130238e-36	2.029880e-38	4.540714e+0	NRG1,NRG3	MammalianAncestor	35.2125
GO.Biological.Process	GO:2000107	negative.regulation.of.leukocyte.apoptotic.process	303	5.076483e-40	6.557293e-36	2.164123e-38	2.570622e+0	AURKB,CXCL12,HCLS1,SLC46A2,TSC22D3	MammalianAncestor	35.1833
GO.Biological.Process	GO:0032656	regulation.of.interleukin-13.production	304	7.354397e-40	9.499675e-36	3.124893e-38	3.911238e+0	IL17RA,NLRP3,SCGB1A1,TNFSF4	MammalianAncestor	35.0223
GO.Biological.Process	GO:0002830	positive.regulation.of.type.2.immune.response	305	7.900899e-40	1.020559e-35	3.346095e-38	4.830298e+0	CD86,IL4R,NLRP3,TNFSF4	MammalianAncestor	34.9912
GO.Biological.Process	GO:1900053	negative.regulation.of.retinoic.acid.biosynthetic.process	306	8.104228e-40	1.046823e-35	3.420991e-38	2.970671e+1	AKR1C3	MammalianAncestor	34.9801
GO.Biological.Process	GO:0042446	hormone.biosynthetic.process	307	8.332332e-40	1.076287e-35	3.505822e-38	2.631158e+0	AKR1B1,DHCR7,DUOX1,DUOX2,HSD17B7,HSD3B1,HSD3B2,SRD5A2,TPO	MammalianAncestor	34.9681
GO.Biological.Process	GO:0006601	creatine.biosynthetic.process	308	1.196733e-39	1.545820e-35	5.018896e-38	3.155989e+1	GATM	MammalianAncestor	34.8108
GO.Biological.Process	GO:0032455	nerve.growth.factor.processing	309	1.540840e-39	1.990303e-35	6.441110e-38	5.848963e+0	FURIN,NGF,PCSK6	MammalianAncestor	34.7011
GO.Biological.Process	GO:0002035	brain.renin-angiotensin.system	310	2.207990e-39	2.852061e-35	9.200196e-38	7.107745e+0	TACR1	MammalianAncestor	34.5448
GO.Biological.Process	GO:0046878	positive.regulation.of.saliva.secretion	311	2.255738e-39	2.913737e-35	9.368929e-38	7.105483e+0	TACR1	MammalianAncestor	34.5355
GO.Biological.Process	GO:0002250	adaptive.immune.response	312	3.805484e-39	4.915544e-35	1.575495e-37	1.715812e+0	ADGRE1,AIRE,BTLA,BTN3A1,BTN3A2,BTN3A3,BTNL8,CD1A,CD1E,CD244,CD79A,CD84,CD86,CLEC10A,CLU,CTSH,DBNL,DLG1,ENSG00000259680,FCGR1B,FCGR2B,FCRL4,ICOSLG,IGLL5,IL4R,JCHAIN,KDM5D,LAT,LILRA6,LILRB2,LILRB3,LILRB5,LY9,MARCH8,MICB,MYO1G,PIK3CB,PRKCB,RELB,RNF8,SCART1,SIGLEC10,SLAMF1,SLAMF6,SLAMF7,TAP2,TARM1,TNFRSF13B,TNFSF18,ZAP70	MammalianAncestor	34.3084
GO.Biological.Process	GO:0009822	alkaloid.catabolic.process	313	4.526460e-39	5.846828e-35	1.867996e-37	1.979613e+1	CYP3A4,CYP3A5	MammalianAncestor	34.2331
GO.Biological.Process	GO:0050866	negative.regulation.of.cell.activation	314	5.396979e-39	6.971278e-35	2.220152e-37	1.783666e+0	ALOX12,BTN2A2,CD200,CD84,CEACAM1,DLG1,DTX1,DUSP22,FCGR2B,HLA-G,HMGB3,IL20RB,IL2RA,IL4R,LILRB2,MNDA,NFKBID,PRNP,RHBDD3,SCGB1A1,SFTPD,SPN,TARM1,TNFRSF13B,TNFSF18,TNFSF4	MammalianAncestor	34.1567
GO.Biological.Process	GO:0002275	myeloid.cell.activation.involved.in.immune.response	315	5.431991e-39	7.016503e-35	2.227461e-37	1.545754e+0	ACTR1B,ALOX5,ARMC8,ASAH1,ATP8B4,B2M,CAMP,CD177,CEACAM1,CEACAM3,CEACAM6,CEACAM8,CHRNB4,CST3,CTSB,CTSG,CTSH,CX3CR1,DBNL,DEFA1,DEFA4,FCGR2A,FCGR3B,FPR1,FPR2,GLA,HGSNAT,HSPA1A,HSPA1B,HSPA6,IMPDH1,IQGAP1,ITGAL,ITGB2,KCMF1,LAT,LBP,LILRB2,LILRB3,LTF,MGAM,MNDA,MRGPRX2,NEU1,ORM1,ORM2,OSCAR,PFKL,PLAUR,PNP,PPIA,PRDX6,QPCT,RAB7A,RAB9B,RNASE2,RNASE3,ROCK1,SERPINB6,SIGLEC14,SIGLEC5,SIGLEC9,SLAMF1,SLC27A2,SNAP29,STK10,TARM1,TMEM179B,TSPAN14,TYROBP,VAMP7	MammalianAncestor	34.1539
GO.Biological.Process	GO:1902430	negative.regulation.of.beta-amyloid.formation	316	5.813142e-39	7.508836e-35	2.376214e-37	5.893151e+0	CHRNA7,CLU,PRNP	MammalianAncestor	34.1244
GO.Biological.Process	GO:0002051	osteoblast.fate.commitment	317	8.318311e-39	1.074476e-34	3.389515e-37	6.450727e+0	SH3PXD2B	MammalianAncestor	33.9688
GO.Biological.Process	GO:0022617	extracellular.matrix.disassembly	318	8.499085e-39	1.097827e-34	3.452286e-37	2.437800e+0	CAPNS1,CMA1,CTSG,CTSV,EXOC8,FN1,FURIN,KLK2,KLK7,SH3PXD2B,WASHC1	MammalianAncestor	33.9595
GO.Biological.Process	GO:0019082	viral.protein.processing	319	1.395519e-38	1.802592e-34	5.650758e-37	3.160141e+1	FURIN	MammalianAncestor	33.7441
GO.Biological.Process	GO:0090472	dibasic.protein.processing	319	1.395519e-38	1.802592e-34	5.650758e-37	3.160141e+1	FURIN	MammalianAncestor	33.7441
GO.Biological.Process	GO:0008207	C21-steroid.hormone.metabolic.process	321	1.456782e-38	1.881725e-34	5.862073e-37	3.992192e+0	AKR1B1,AKR1C1,AKR1C2,AKR1C3,SRD5A2	MammalianAncestor	33.7254
GO.Biological.Process	GO:0045780	positive.regulation.of.bone.resorption	322	2.284737e-38	2.951195e-34	9.165201e-37	3.349761e+0	EGFR,MC4R,PLEKHM1	MammalianAncestor	33.53
GO.Biological.Process	GO:1903901	negative.regulation.of.viral.life.cycle	323	2.464202e-38	3.183010e-34	9.854519e-37	2.603251e+0	APCS,IFI16,LTF,MAVS,MID2,OAS1,OAS3,REST,TRIM10,TRIM11,TRIM14,TRIM15,TRIM26,TRIM27,TRIM31	MammalianAncestor	33.4972
GO.Biological.Process	GO:0030200	heparan.sulfate.proteoglycan.catabolic.process	324	2.719593e-38	3.512898e-34	1.084228e-36	1.253343e+1	GPC1	MammalianAncestor	33.4543
GO.Biological.Process	GO:0044273	sulfur.compound.catabolic.process	325	4.781982e-38	6.176886e-34	1.900580e-36	2.694297e+0	CSPG4,GGT1,GGT2,GGT6,GGTLC1,GGTLC2,GPC1,MAT1A	MammalianAncestor	33.2092
GO.Biological.Process	GO:0006703	estrogen.biosynthetic.process	326	5.036108e-38	6.505141e-34	1.995442e-36	6.198570e+0	HSD17B7,HSD3B1	MammalianAncestor	33.1867
GO.Biological.Process	GO:0032703	negative.regulation.of.interleukin-2.production	327	5.686694e-38	7.345503e-34	2.246331e-36	3.199649e+0	IL20RB,PRNP,SFTPD,TRIM27	MammalianAncestor	33.134
GO.Biological.Process	GO:0072643	interferon-gamma.secretion	328	8.203076e-38	1.059591e-33	3.230461e-36	5.989322e+0	BTN3A1,BTN3A2,TRIM27	MammalianAncestor	32.9749
GO.Biological.Process	GO:0022029	telencephalon.cell.migration	329	9.096525e-38	1.174998e-33	3.571423e-36	1.937518e+0	CX3CR1,CXCL12,EGFR,FUT10,LAMB1,LRRK2,NRG1,NRG3,SRGAP2C	MammalianAncestor	32.93
GO.Biological.Process	GO:0002765	immune.response-inhibiting.signal.transduction	330	1.691101e-37	2.184395e-33	6.619379e-36	6.881218e+0	HLA-G,IL20RB,LILRB2	MammalianAncestor	32.6607
GO.Biological.Process	GO:0070474	positive.regulation.of.uterine.smooth.muscle.contraction	331	2.225895e-37	2.875189e-33	8.686370e-36	5.293017e+0	ADRA2B,TACR1	MammalianAncestor	32.5413
GO.Biological.Process	GO:0008154	actin.polymerization.or.depolymerization	332	2.988484e-37	3.860225e-33	1.162718e-35	2.800980e+0	ANG,COBL,GHRL,HCLS1,WAS	MammalianAncestor	32.4134
GO.Biological.Process	GO:0002819	regulation.of.adaptive.immune.response	333	3.464192e-37	4.474697e-33	1.343753e-35	1.957034e+0	ALOX15,APLF,B2M,CD48,CEACAM1,DUSP22,FCER1A,FCGR2B,IL20RB,IL4R,LTA,NLRP3,PVR,SLAMF1,SPN,TNFSF18,TNFSF4,TRIM27,WAS	MammalianAncestor	32.3492
GO.Biological.Process	GO:0006686	sphingomyelin.biosynthetic.process	334	7.751892e-37	1.001312e-32	2.997940e-35	6.834366e+0	SGMS1	MammalianAncestor	31.9994
GO.Biological.Process	GO:0046597	negative.regulation.of.viral.entry.into.host.cell	335	8.018190e-37	1.035710e-32	3.091670e-35	5.726762e+0	APCS,MID2,TRIM10,TRIM11,TRIM26,TRIM31	MammalianAncestor	31.9848
GO.Biological.Process	GO:0002385	mucosal.immune.response	336	9.030539e-37	1.166475e-32	3.471651e-35	4.882076e+0	CAMP,DEFA1,DEFA3,DEFB1,HIST1H2BJ,HIST1H2BK,LTF,RNASE3	MammalianAncestor	31.9331
GO.Biological.Process	GO:2000316	regulation.of.T-helper.17.type.immune.response	337	1.069979e-36	1.382092e-32	4.101163e-35	4.144798e+0	NLRP3,TNFSF18	MammalianAncestor	31.8595
GO.Biological.Process	GO:0014059	regulation.of.dopamine.secretion	338	1.176053e-36	1.519108e-32	4.494401e-35	2.493184e+0	CHRNA6,CXCL12,OR13F1	MammalianAncestor	31.8184
GO.Biological.Process	GO:0006694	steroid.biosynthetic.process	339	1.212848e-36	1.566636e-32	4.621344e-35	2.102885e+0	AKR1B1,AKR1C3,AKR1C4,BAAT,CYP3A4,DHCR7,EBP,FDFT1,HMGCS2,HSD17B7,HSD3B1,HSD3B2,NSDHL,SLC27A2,SRD5A2	MammalianAncestor	31.805
GO.Biological.Process	GO:0097011	cellular.response.to.granulocyte.macrophage.colony-stimulating.factor.stimulus	340	1.372398e-36	1.772726e-32	5.213901e-35	6.355690e+0	ETV3	MammalianAncestor	31.7514
GO.Biological.Process	GO:0006790	sulfur.compound.metabolic.process	341	1.392253e-36	1.798373e-32	5.273822e-35	1.504324e+0	B3GAT1,B4GAT1,BAAT,CBSL,CHST13,CHST7,CHSY3,CSGALNACT1,CSGALNACT2,CSPG4,FAR1,FAR2,GGT1,GGT2,GGT6,GGTLC1,GGTLC2,GPC1,GSR,HS6ST1,MAT1A,MSRA,MUT,NAT8,PAX8,PC,PPT2,PXYLP1,SQOR,SULT1A3,SULT1A4,SULT1B1,SULT1E1,SULT2A1,SULT2B1,TPK1,VANGL2,XYLT2	MammalianAncestor	31.7451
GO.Biological.Process	GO:0060588	negative.regulation.of.lipoprotein.lipid.oxidation	342	1.537433e-36	1.985902e-32	5.806732e-35	2.949815e+1	APOD	MammalianAncestor	31.702
GO.Biological.Process	GO:0032147	activation.of.protein.kinase.activity	343	1.556475e-36	2.010499e-32	5.861512e-35	1.498002e+0	ACVR2B,ADCY1,ADORA2B,ADRA2B,ANG,ARAF,CHRNA3,CHRNA7,CRKL,CSPG4,CXCL17,DBNL,DLG1,EGFR,ERCC6,ERN2,FCER1A,FPR1,GHRL,INAVA,INSR,IRAK2,ITGB3,LPAR1,LRRK2,MAP2K4,MAP2K7,MAP3K2,MAP4K3,MUC20,NGF,NRG1,NRG3,PIK3CB,PILRB,PRNP,RIPK1,STK10,STK26,TDGF1,TGFA,TGFBR1	MammalianAncestor	31.6967
GO.Biological.Process	GO:0002274	myeloid.leukocyte.activation	344	2.285275e-36	2.951890e-32	8.581075e-35	1.483767e+0	ACTR1B,ALOX5,ARMC8,ASAH1,ATP8B4,B2M,CAMP,CD177,CD244,CD86,CEACAM1,CEACAM3,CEACAM6,CEACAM8,CHRNB4,CLU,CRTC3,CST3,CTSB,CTSG,CTSH,CX3CR1,DBNL,DEFA1,DEFA4,FCGR2A,FCGR3B,FPR1,FPR2,GLA,HGSNAT,HSPA1A,HSPA1B,HSPA6,IMPDH1,IQGAP1,ITGAL,ITGB2,KCMF1,LAT,LBP,LILRB2,LILRB3,LTF,MAPT,MGAM,MNDA,MRGPRX2,NEU1,ORM1,ORM2,OSCAR,PFKL,PLAUR,PNP,PPIA,PRDX6,QPCT,RAB7A,RAB9B,RELB,RNASE2,RNASE3,ROCK1,SERPINB6,SIGLEC14,SIGLEC5,SIGLEC9,SLAMF1,SLC27A2,SNAP29,STK10,TARM1,TMEM179B,TSPAN14,TYROBP,UBD,VAMP7	MammalianAncestor	31.5299
GO.Biological.Process	GO:0050982	detection.of.mechanical.stimulus	345	2.593375e-36	3.349862e-32	9.709746e-35	2.459691e+0	CXCL12,PKD1L1,TMC2	MammalianAncestor	31.475
GO.Biological.Process	GO:0043496	regulation.of.protein.homodimerization.activity	346	2.746046e-36	3.547068e-32	1.025164e-34	2.922527e+0	BAK1,NRG1,TNFSF18	MammalianAncestor	31.4501
GO.Biological.Process	GO:0010907	positive.regulation.of.glucose.metabolic.process	347	3.051620e-36	3.941778e-32	1.135959e-34	2.678050e+0	ACTN3,INSR,PMAIP1,RGN,SORBS1	MammalianAncestor	31.4043
GO.Biological.Process	GO:0014894	response.to.denervation.involved.in.regulation.of.muscle.adaptation	348	3.527231e-36	4.556124e-32	1.309231e-34	4.753812e+0	ACTN3,HDAC4	MammalianAncestor	31.3414
GO.Biological.Process	GO:0007006	mitochondrial.membrane.organization	349	4.081608e-36	5.272213e-32	1.510663e-34	2.061148e+0	BAK1,CHCHD6,GZMB,HK2,HSPA1A,HSPA4,MTRNR2L5,PMAIP1,YWHAE	MammalianAncestor	31.278
GO.Biological.Process	GO:0042445	hormone.metabolic.process	350	5.350265e-36	6.910937e-32	1.974554e-34	1.759080e+0	AKR1B1,AKR1C1,AKR1C2,AKR1C3,AKR1C4,CMA1,CTSG,CYP1B1,CYP3A4,DHCR7,DUOX1,DUOX2,FOXE1,FURIN,HSD17B7,HSD3B1,HSD3B2,KLK6,NGF,PCSK1N,PCSK6,SRD5A2,SULT1B1,SULT1E1,TPO,UGT2B4,UGT2B7	MammalianAncestor	31.1605
GO.Biological.Process	GO:0002506	polysaccharide.assembly.with.MHC.class.II.protein.complex	351	6.540374e-36	8.448201e-32	2.406895e-34	2.446102e+1	HLA-DRA,HLA-DRB1	MammalianAncestor	31.0732
GO.Biological.Process	GO:0031338	regulation.of.vesicle.fusion	352	7.422780e-36	9.588005e-32	2.723865e-34	2.251496e+0	EVI5L,SGSM1,SLAMF1,STXBP6,TBC1D10B,TBC1D12,TBC1D2,TBC1D22B,TBC1D25,TBC1D26,TBC1D2B,TBC1D3K,TBC1D8B,USP6	MammalianAncestor	31.0183
GO.Biological.Process	GO:0072757	cellular.response.to.camptothecin	353	1.011356e-35	1.306369e-31	3.700761e-34	5.990615e+0	BLM,SPIDR	MammalianAncestor	30.8839
GO.Biological.Process	GO:0035335	peptidyl-tyrosine.dephosphorylation	354	1.053360e-35	1.360625e-31	3.843574e-34	1.859305e+0	ACP1,CDC25A,DUSP1,DUSP11,DUSP12,DUSP22,DUSP23,DUSP4,MTMR8,PTPN18,PTPN20,PTPN3,PTPN4,PTPN5,PTPRA,TPTE	MammalianAncestor	30.8663
GO.Biological.Process	GO:0038158	granulocyte.colony-stimulating.factor.signaling.pathway	355	1.081109e-35	1.396468e-31	3.933714e-34	2.996349e+1	CEACAM1	MammalianAncestor	30.855
GO.Biological.Process	GO:0010827	regulation.of.glucose.transport	356	1.098697e-35	1.419187e-31	3.986480e-34	2.235981e+0	CAPN10,GRB10,HK2,INSR,ITLN1,PRKCB,SLC2A1,SORBS1	MammalianAncestor	30.848
GO.Biological.Process	GO:1904923	regulation.of.mitophagy.in.response.to.mitochondrial.depolarization	357	1.172456e-35	1.514461e-31	4.242189e-34	7.144760e+0	HK2	MammalianAncestor	30.8197
GO.Biological.Process	GO:0021885	forebrain.cell.migration	358	1.647866e-35	2.128549e-31	5.945666e-34	1.892490e+0	CX3CR1,CXCL12,EGFR,FUT10,LAMB1,LRRK2,NRG1,NRG3,SRGAP2C	MammalianAncestor	30.6719
GO.Biological.Process	GO:0060674	placenta.blood.vessel.development	359	1.870242e-35	2.415792e-31	6.729224e-34	2.958027e+0	HS6ST1,NSDHL	MammalianAncestor	30.6169
GO.Biological.Process	GO:1904016	response.to.Thyroglobulin.triiodothyronine	360	1.907271e-35	2.463622e-31	6.843394e-34	7.658850e+0	SLC2A1	MammalianAncestor	30.6084
GO.Biological.Process	GO:0014870	response.to.muscle.inactivity	361	1.950684e-35	2.519699e-31	6.979774e-34	4.654086e+0	ACTN3,HDAC4	MammalianAncestor	30.5987
GO.Biological.Process	GO:0086023	adrenergic.receptor.signaling.pathway.involved.in.heart.process	362	2.208426e-35	2.852624e-31	7.880176e-34	4.365771e+0	AKAP13	MammalianAncestor	30.5448
GO.Biological.Process	GO:0042167	heme.catabolic.process	363	2.369494e-35	3.060675e-31	8.431613e-34	1.087324e+1	AMBP,BLVRA	MammalianAncestor	30.5142
GO.Biological.Process	GO:0042130	negative.regulation.of.T.cell.proliferation	364	2.811918e-35	3.632154e-31	9.978446e-34	2.436206e+0	BTN2A2,DLG1,HLA-G,IL20RB,IL2RA,LILRB2,PRNP,SCGB1A1,SFTPD,SPN	MammalianAncestor	30.4398
GO.Biological.Process	GO:0031640	killing.of.cells.of.other.organism	365	2.942087e-35	3.800294e-31	1.041176e-33	3.133114e+0	CAMP,CST11,CTSG,DEFA1,DEFA3,DEFA4,DEFA5,DEFA6,DEFB103A,DEFB103B,DEFB128,DEFB132,DEFB4A,DEFB4B,GNLY,HIST1H2BJ,HIST1H2BK,HTN1,HTN3,LTF,MUC7,REG3G,RPS19	MammalianAncestor	30.4202
GO.Biological.Process	GO:0003365	establishment.of.cell.polarity.involved.in.ameboidal.cell.migration	366	2.964363e-35	3.829068e-31	1.046193e-33	6.909698e+0	AMOT	MammalianAncestor	30.4169
GO.Biological.Process	GO:0061820	telomeric.D-loop.disassembly	367	3.220985e-35	4.160546e-31	1.133664e-33	4.669248e+0	BLM,SLX1B,WRN	MammalianAncestor	30.3808
GO.Biological.Process	GO:0019369	arachidonic.acid.metabolic.process	368	3.565185e-35	4.605149e-31	1.251399e-33	2.963324e+0	AKR1C3,ALOX12,ALOX12B,ALOX15,ALOX15B,ALOXE3,CYP1B1,CYP2E1,CYP4F12,CYP4F2,EPHX2,FAAH2,PLA2G4C	MammalianAncestor	30.3368
GO.Biological.Process	GO:0043163	cell.envelope.organization	369	3.586128e-35	4.632202e-31	1.255339e-33	1.444052e+1	TGM3	MammalianAncestor	30.3342
GO.Biological.Process	GO:1905664	regulation.of.calcium.ion.import.across.plasma.membrane	370	3.794472e-35	4.901319e-31	1.324681e-33	5.958787e+0	PRNP,RAMP3	MammalianAncestor	30.3097
GO.Biological.Process	GO:0006968	cellular.defense.response	371	4.696106e-35	6.065960e-31	1.635030e-33	3.058090e+0	ADORA2B,CCR5,CD160,CD5L,CX3CR1,GAGE1,GNLY,HLA-G,LBP,LILRB2,MNDA,PAGE1,SPN,TYROBP	MammalianAncestor	30.2171
GO.Biological.Process	GO:1990519	mitochondrial.pyrimidine.nucleotide.import	372	5.674799e-35	7.330138e-31	1.970467e-33	1.138727e+1	SLC25A36	MammalianAncestor	30.1349
GO.Biological.Process	GO:0006863	purine.nucleobase.transport	373	5.754323e-35	7.432859e-31	1.992724e-33	6.287913e+0	SLC28A1,VDAC3	MammalianAncestor	30.1288
GO.Biological.Process	GO:0045622	regulation.of.T-helper.cell.differentiation	374	5.974338e-35	7.717052e-31	2.063383e-33	2.841805e+0	CD86,IL4R,NLRP3,TNFSF18,TNFSF4	MammalianAncestor	30.1125
GO.Biological.Process	GO:0072711	cellular.response.to.hydroxyurea	375	5.980092e-35	7.724485e-31	2.059863e-33	3.965255e+0	BLM,NSMCE3,SPIDR	MammalianAncestor	30.1121
GO.Biological.Process	GO:0018279	protein.N-linked.glycosylation.via.asparagine	376	5.980162e-35	7.724575e-31	2.054408e-33	2.537853e+0	ASGR1,ASGR2,DAD1,RPN2	MammalianAncestor	30.1121
GO.Biological.Process	GO:1901184	regulation.of.ERBB.signaling.pathway	377	6.141380e-35	7.932821e-31	2.104196e-33	1.907062e+0	ADRA2B,CEACAM1,EGFR,EPN1,FASLG,HIP1,NRG1,PLAUR,PTPN18,PTPN3,RAB7A,RNF115,TGFA	MammalianAncestor	30.1006
GO.Biological.Process	GO:0072655	establishment.of.protein.localization.to.mitochondrion	378	7.537794e-35	9.736569e-31	2.575812e-33	2.504681e+0	AIP,CHCHD4,FIS1,HK2,HSPA4,PMAIP1,TIMM17B,TIMM44,TOMM40L	MammalianAncestor	30.0116
GO.Biological.Process	GO:0002709	regulation.of.T.cell.mediated.immunity	379	9.471451e-35	1.223427e-30	3.228040e-33	2.611606e+0	B2M,CEACAM1,DUSP22,FCGR2B,IL20RB,NLRP3,PVR,SLAMF1,SPN,TNFSF4,WAS	MammalianAncestor	29.9124
GO.Biological.Process	GO:0060133	somatotropin.secreting.cell.development	380	9.778020e-35	1.263027e-30	3.323755e-33	9.397649e+0	POU1F1	MammalianAncestor	29.8986
GO.Biological.Process	GO:0001580	detection.of.chemical.stimulus.involved.in.sensory.perception.of.bitter.taste	381	1.023296e-34	1.321791e-30	3.469269e-33	4.184034e+0	AZGP1,CST1,CST2,CST4,RTP3,RTP5,TAS2R3,TAS2R38,TAS2R4,TAS2R5	MammalianAncestor	29.8788
GO.Biological.Process	GO:0043318	negative.regulation.of.cytotoxic.T.cell.degranulation	382	1.080396e-34	1.395548e-30	3.653266e-33	2.405191e+1	CEACAM1,FCGR2B	MammalianAncestor	29.8553
GO.Biological.Process	GO:1901563	response.to.camptothecin	383	1.117239e-34	1.443138e-30	3.767983e-33	5.781119e+0	BLM,SPIDR	MammalianAncestor	29.8407
GO.Biological.Process	GO:0048011	neurotrophin.TRK.receptor.signaling.pathway	384	1.229870e-34	1.588623e-30	4.137039e-33	4.350211e+0	NDN,NGF	MammalianAncestor	29.799
GO.Biological.Process	GO:2000568	positive.regulation.of.memory.T.cell.activation	385	1.522835e-34	1.967046e-30	5.109210e-33	8.418591e+0	TNFSF4	MammalianAncestor	29.7062
GO.Biological.Process	GO:0006705	mineralocorticoid.biosynthetic.process	386	1.727149e-34	2.230958e-30	5.779685e-33	1.190409e+1	HSD3B1,HSD3B2	MammalianAncestor	29.6515
GO.Biological.Process	GO:0007044	cell-substrate.junction.assembly	387	1.822335e-34	2.353910e-30	6.082455e-33	2.755468e+0	ACTN3,ENSG00000259753,FN1,ITGB3,RHOD,SORBS1	MammalianAncestor	29.6282
GO.Biological.Process	GO:2000379	positive.regulation.of.reactive.oxygen.species.metabolic.process	388	2.100077e-34	2.712669e-30	6.991416e-33	2.079957e+0	AKR1C3,CD177,CLU,CRP,DDAH2,EGFR,FPR2,HDAC4,INSR,ITGB2,MAPT,NOS1AP,NQO2,RGN,RIPK1,XDH	MammalianAncestor	29.5666
GO.Biological.Process	GO:0000578	embryonic.axis.specification	389	2.391744e-34	3.089416e-30	7.941943e-33	2.411268e+0	COBL,EPB41L5,PCSK6,TDGF1,WNT7A	MammalianAncestor	29.5101
GO.Biological.Process	GO:0001976	neurological.system.process.involved.in.regulation.of.systemic.arterial.blood.pressure	390	2.418732e-34	3.124276e-30	8.010964e-33	3.349567e+0	ADRA1A,CHRNA7,TACR1	MammalianAncestor	29.5053
GO.Biological.Process	GO:0016488	farnesol.catabolic.process	391	2.478579e-34	3.201580e-30	8.188185e-33	2.061705e+1	AKR1C3	MammalianAncestor	29.4946
GO.Biological.Process	GO:0033345	asparagine.catabolic.process.via.L-aspartate	392	2.804317e-34	3.622336e-30	9.240654e-33	3.812120e+1	ASRGL1	MammalianAncestor	29.441
GO.Biological.Process	GO:0006880	intracellular.sequestering.of.iron.ion	393	2.893566e-34	3.737619e-30	9.510481e-33	4.976992e+0	FTMT	MammalianAncestor	29.4274
GO.Biological.Process	GO:1903556	negative.regulation.of.tumor.necrosis.factor.superfamily.cytokine.production	394	3.008983e-34	3.886703e-30	9.864729e-33	2.860784e+0	ACP5,CHRNA7,GHRL,LBP,LTF,NFKBIL1,ORM1,SLAMF1,TRIM27	MammalianAncestor	29.4104
GO.Biological.Process	GO:0090657	telomeric.loop.disassembly	395	3.041542e-34	3.928760e-30	9.946227e-33	4.539093e+0	BLM,SLX1B,WRN	MammalianAncestor	29.4057
GO.Biological.Process	GO:0060083	smooth.muscle.contraction.involved.in.micturition	396	3.150570e-34	4.069591e-30	1.027675e-32	5.941143e+0	TACR1	MammalianAncestor	29.3904
GO.Biological.Process	GO:0006029	proteoglycan.metabolic.process	397	3.322928e-34	4.292226e-30	1.081165e-32	1.774244e+0	B3GAT1,CHST13,CHST7,CHSY3,CSGALNACT1,CSGALNACT2,CSPG4,GPC1,HS6ST1,PXYLP1,VANGL2,XYLT2	MammalianAncestor	29.3673
GO.Biological.Process	GO:0000302	response.to.reactive.oxygen.species	398	3.375509e-34	4.360145e-30	1.095514e-32	1.759404e+0	AKR1B1,AKR1C3,APOD,BAK1,COL1A1,CST3,CYP1B1,CYP2E1,DUSP1,EGFR,ERCC6,HDAC6,MAPK7,PAX2,SCGB1A1,SLC8A1,STK26,TACR1,TXNIP,TXNRD3,UBE3A	MammalianAncestor	29.3605
GO.Biological.Process	GO:0018196	peptidyl-asparagine.modification	399	5.124673e-34	6.619540e-30	1.659033e-32	2.499366e+0	ASGR1,ASGR2,DAD1,RPN2	MammalianAncestor	29.1792
GO.Biological.Process	GO:2001300	lipoxin.metabolic.process	400	6.047235e-34	7.811213e-30	1.952803e-32	7.071586e+0	ALOX12,ALOX15,ALOX5	MammalianAncestor	29.1073
GO.Biological.Process	GO:0050832	defense.response.to.fungus	401	6.213571e-34	8.026070e-30	2.001514e-32	4.722259e+0	CTSG,DEFA1,DEFA3,DEFA4,DEFA5,DEFA6,GNLY,HTN1,HTN3,IL17RA,LTF,RNASE7,RNASE8	MammalianAncestor	29.0955
GO.Biological.Process	GO:0097345	mitochondrial.outer.membrane.permeabilization	402	6.584571e-34	8.505290e-30	2.115744e-32	4.192692e+0	PMAIP1	MammalianAncestor	29.0703
GO.Biological.Process	GO:2001199	negative.regulation.of.dendritic.cell.differentiation	403	6.675165e-34	8.622311e-30	2.139531e-32	1.154394e+1	FCGR2B,HLA-G	MammalianAncestor	29.0644
GO.Biological.Process	GO:0034310	primary.alcohol.catabolic.process	404	7.411911e-34	9.573965e-30	2.369793e-32	4.711313e+0	AKR1C3,SULT1A3,SULT1B1,SULT1E1,SULT2A1	MammalianAncestor	29.0189
GO.Biological.Process	GO:0072710	response.to.hydroxyurea	405	8.155337e-34	1.053425e-29	2.601049e-32	3.851505e+0	BLM,NSMCE3,SPIDR	MammalianAncestor	28.9774
GO.Biological.Process	GO:0071875	adrenergic.receptor.signaling.pathway	406	1.038399e-33	1.341300e-29	3.303695e-32	2.709628e+0	ADRA1A,ADRA1D,ADRA2B,AKAP13	MammalianAncestor	28.8725
GO.Biological.Process	GO:0070885	negative.regulation.of.calcineurin-NFAT.signaling.cascade	407	1.146187e-33	1.480530e-29	3.637665e-32	9.447246e+0	ACTN3,PRNP	MammalianAncestor	28.8296
GO.Biological.Process	GO:0009258	10-formyltetrahydrofolate.catabolic.process	408	1.275577e-33	1.647663e-29	4.038389e-32	1.441618e+1	ALDH1L1	MammalianAncestor	28.7831
GO.Biological.Process	GO:0034443	negative.regulation.of.lipoprotein.oxidation	409	1.432611e-33	1.850504e-29	4.524459e-32	2.379007e+1	APOD	MammalianAncestor	28.7327
GO.Biological.Process	GO:0006060	sorbitol.metabolic.process	410	1.470558e-33	1.899520e-29	4.632975e-32	1.658092e+1	AKR1B1,SORD	MammalianAncestor	28.7214
GO.Biological.Process	GO:0046370	fructose.biosynthetic.process	410	1.470558e-33	1.899520e-29	4.632975e-32	1.658092e+1	AKR1B1,SORD	MammalianAncestor	28.7214
GO.Biological.Process	GO:0030320	cellular.monovalent.inorganic.anion.homeostasis	412	1.480293e-33	1.912094e-29	4.641006e-32	4.668555e+0	FASLG,GPCPD1	MammalianAncestor	28.7185
GO.Biological.Process	GO:0043299	leukocyte.degranulation	413	1.488791e-33	1.923071e-29	4.656347e-32	1.508855e+0	ACTR1B,ALOX5,ARMC8,ASAH1,ATP8B4,B2M,CAMP,CD177,CEACAM1,CEACAM3,CEACAM6,CEACAM8,CHRNB4,CST3,CTSB,CTSG,CTSH,DBNL,DEFA1,DEFA4,FCGR2A,FCGR3B,FPR1,FPR2,GLA,HGSNAT,HSPA1A,HSPA1B,HSPA6,IMPDH1,IQGAP1,ITGAL,ITGB2,KCMF1,LAT,LILRB2,LILRB3,LTF,MGAM,MNDA,MRGPRX2,NEU1,ORM1,ORM2,OSCAR,PFKL,PLAUR,PNP,PPIA,PRDX6,QPCT,RAB7A,RAB9B,RNASE2,RNASE3,ROCK1,SERPINB6,SIGLEC14,SIGLEC5,SIGLEC9,SLC27A2,SNAP29,STK10,TARM1,TMEM179B,TSPAN14,TYROBP,VAMP7	MammalianAncestor	28.716
GO.Biological.Process	GO:0030307	positive.regulation.of.cell.growth	414	1.585781e-33	2.048353e-29	4.947713e-32	1.686791e+0	ADNP2,ALOX12,ATP6V1G2-DDX39B,CXCL12,EGFR,FN1,IGFBP1,IL9R,LIMK1,MAPT,NRG1,TAF9B,TGFBR1,TRPV2	MammalianAncestor	28.6886
GO.Biological.Process	GO:0050654	chondroitin.sulfate.proteoglycan.metabolic.process	415	2.569968e-33	3.319628e-29	7.999103e-32	2.200367e+0	B3GAT1,CHST13,CHST7,CHSY3,CSGALNACT1,CSGALNACT2,CSPG4,PXYLP1,XYLT2	MammalianAncestor	28.4789
GO.Biological.Process	GO:0042743	hydrogen.peroxide.metabolic.process	416	2.661962e-33	3.438456e-29	8.265520e-32	3.609682e+0	DUOX1,DUOX2,EGFR,PRDX6,TPO	MammalianAncestor	28.4636
GO.Biological.Process	GO:0050748	negative.regulation.of.lipoprotein.metabolic.process	417	2.774692e-33	3.584070e-29	8.594891e-32	1.247636e+1	APOD,ITGB3	MammalianAncestor	28.4456
GO.Biological.Process	GO:0070585	protein.localization.to.mitochondrion	418	3.532959e-33	4.563523e-29	1.091752e-31	2.353494e+0	AIP,CHCHD4,FIS1,HK2,HSPA4,LRRK2,PMAIP1,TIMM17B,TIMM44,TOMM40L	MammalianAncestor	28.3407
GO.Biological.Process	GO:0070933	histone.H4.deacetylation	419	3.910652e-33	5.051389e-29	1.205582e-31	4.206007e+0	HDAC4,REST	MammalianAncestor	28.2966
GO.Biological.Process	GO:0090073	positive.regulation.of.protein.homodimerization.activity	420	5.279754e-33	6.819858e-29	1.623776e-31	4.338123e+0	TNFSF18	MammalianAncestor	28.1662
GO.Biological.Process	GO:1902992	negative.regulation.of.amyloid.precursor.protein.catabolic.process	421	5.502404e-33	7.107455e-29	1.688232e-31	4.886865e+0	CHRNA7,CLU,PRNP	MammalianAncestor	28.1483
GO.Biological.Process	GO:0050860	negative.regulation.of.T.cell.receptor.signaling.pathway	422	5.794088e-33	7.484223e-29	1.773513e-31	3.930677e+0	CEACAM1,DUSP22,PRNP,PVRIG	MammalianAncestor	28.1259
GO.Biological.Process	GO:0031284	positive.regulation.of.guanylate.cyclase.activity	423	7.596204e-33	9.812017e-29	2.319626e-31	4.864985e+0	ADORA2B,ENSG00000214732,GUCA1B,GUCA2A,GUCA2B	MammalianAncestor	28.0082
GO.Biological.Process	GO:0002366	leukocyte.activation.involved.in.immune.response	424	7.720683e-33	9.972806e-29	2.352077e-31	1.435443e+0	ACTR1B,ALOX5,ARMC8,ASAH1,ATP8B4,B2M,CAMP,CD177,CD244,CD86,CEACAM1,CEACAM3,CEACAM6,CEACAM8,CHRNB4,CST3,CTSB,CTSG,CTSH,CX3CR1,DBNL,DEFA1,DEFA4,FCGR2A,FCGR2B,FCGR3B,FPR1,FPR2,GLA,HGSNAT,HSPA1A,HSPA1B,HSPA6,IMPDH1,IQGAP1,ITGAL,ITGB2,KCMF1,LAT,LBP,LILRB2,LILRB3,LTF,LY9,MGAM,MNDA,MRGPRX2,NEU1,ORM1,ORM2,OSCAR,PFKL,PLAUR,PNP,PPIA,PRDX6,QPCT,RAB7A,RAB9B,RELB,RNASE2,RNASE3,RNF8,ROCK1,SERPINB6,SIGLEC14,SIGLEC5,SIGLEC9,SLAMF1,SLAMF6,SLC27A2,SNAP29,STK10,TARM1,TMEM179B,TNFSF18,TSPAN14,TYROBP,VAMP7	MammalianAncestor	28.0012
GO.Biological.Process	GO:0032700	negative.regulation.of.interleukin-17.production	425	7.811560e-33	1.009019e-28	2.374163e-31	4.069641e+0	PRNP,TNFSF4	MammalianAncestor	27.9961
GO.Biological.Process	GO:0046006	regulation.of.activated.T.cell.proliferation	426	8.903313e-33	1.150041e-28	2.699627e-31	2.965368e+0	BTN2A2,CD86,ICOSLG,IL2RA,PRNP,SLAMF1,TNFSF4	MammalianAncestor	27.9393
GO.Biological.Process	GO:0001787	natural.killer.cell.proliferation	427	1.200106e-32	1.550177e-28	3.630391e-31	1.361259e+1	SLAMF1,SLAMF6	MammalianAncestor	27.8096
GO.Biological.Process	GO:1905710	positive.regulation.of.membrane.permeability	428	1.819557e-32	2.350322e-28	5.491406e-31	3.556996e+0	DEFA5,PMAIP1	MammalianAncestor	27.6289
GO.Biological.Process	GO:0046639	negative.regulation.of.alpha-beta.T.cell.differentiation	429	2.526466e-32	3.263436e-28	7.607077e-31	2.972179e+0	IL4R,TNFSF18,TNFSF4	MammalianAncestor	27.4863
GO.Biological.Process	GO:0031282	regulation.of.guanylate.cyclase.activity	430	2.687332e-32	3.471227e-28	8.072620e-31	4.779959e+0	ADORA2B,ENSG00000214732,GUCA1B,GUCA2A,GUCA2B	MammalianAncestor	27.4595
GO.Biological.Process	GO:0019372	lipoxygenase.pathway	431	2.772438e-32	3.581158e-28	8.308952e-31	4.942058e+0	ALOX12,ALOX12B,ALOX15,ALOX15B,ALOX5,ALOXE3	MammalianAncestor	27.446
GO.Biological.Process	GO:0032012	regulation.of.ARF.protein.signal.transduction	432	2.840095e-32	3.668551e-28	8.492016e-31	3.803183e+0	PSD3	MammalianAncestor	27.4355
GO.Biological.Process	GO:0010025	wax.biosynthetic.process	433	2.998967e-32	3.873766e-28	8.946341e-31	5.460531e+0	FAR1,FAR2	MammalianAncestor	27.4119
GO.Biological.Process	GO:1903514	calcium.ion.transport.from.endoplasmic.reticulum.to.cytosol	434	3.024545e-32	3.906805e-28	9.001854e-31	5.054046e+0	CCR5,FASLG	MammalianAncestor	27.4082
GO.Biological.Process	GO:0016267	O-glycan.processing,.core.1	435	3.217667e-32	4.156260e-28	9.554622e-31	7.964248e+0	C1GALT1	MammalianAncestor	27.3813
GO.Biological.Process	GO:0009607	response.to.biotic.stimulus	436	3.682139e-32	4.756219e-28	1.090876e-30	1.353634e+0	ACP5,AP1S1,B2M,BAK1,CAMP,CCR5,CD160,CD1D,CD207,CD86,CLU,CRP,CST11,CST9,CTSG,CX3CR1,CXCL12,DEFA1,DEFA3,DEFA4,DEFA5,DEFA6,DEFB1,DEFB103A,DEFB103B,DEFB107A,DEFB107B,DEFB108B,DEFB115,DEFB116,DEFB121,DEFB123,DEFB124,DEFB125,DEFB126,DEFB127,DEFB128,DEFB129,DEFB130A,DEFB130B,DEFB131B,DEFB132,DEFB134,DEFB135,DEFB136,DEFB4A,DEFB4B,DUOX2,ENSG00000259680,ENSG00000283758,FASLG,FBXO18,FCGR2B,GALP,GNLY,HIST1H2BJ,HIST1H2BK,HTN1,HTN3,IFI16,IGLL5,IL17RA,IL4R,INAVA,IRAK2,ITLN1,JCHAIN,KLK3,LBP,LILRB2,LTA,LTF,LYPD8,MAVS,NCK1,NFKBIL1,NLRP1,NLRP3,NLRP9,OAS1,OAS2,OAS3,PMAIP1,POLR3K,PRRT1,REG3A,REG3G,RNASE2,RNASE3,RNASE6,RNASE7,RNASE8,RPS19,SCGB1A1,SERINC5,SERPINB9,SERPINE1,SFTPD,SPACA4,SPACA5,SPACA5B,SPN,STATH,SYNDIG1,TNFSF4,TRIM11,TRIM56,TUSC5,TXNIP,VGF,ZMYND11,ZNF175	MammalianAncestor	27.3227
GO.Biological.Process	GO:1902722	positive.regulation.of.prolactin.secretion	437	5.702596e-32	7.366043e-28	1.685593e-30	9.777991e+0	EGFR	MammalianAncestor	27.1328
GO.Biological.Process	GO:0006055	CMP-N-acetylneuraminate.biosynthetic.process	438	5.884145e-32	7.600550e-28	1.735285e-30	3.132285e+1	NANS	MammalianAncestor	27.1192
GO.Biological.Process	GO:0000187	activation.of.MAPK.activity	439	5.912304e-32	7.636923e-28	1.739618e-30	1.706342e+0	ADORA2B,ADRA2B,CHRNA7,CSPG4,CXCL17,DBNL,ERCC6,ERN2,FCER1A,FPR1,GHRL,INAVA,INSR,IRAK2,LPAR1,LRRK2,MAP2K4,MAP2K7,MAP3K2,MUC20,NRG1,PIK3CB,RIPK1,TDGF1,TGFA	MammalianAncestor	27.1171
GO.Biological.Process	GO:0070231	T.cell.apoptotic.process	440	5.921572e-32	7.648895e-28	1.738385e-30	3.970725e+0	BAK1,FASLG,IL2RA,RIPK1	MammalianAncestor	27.1164
GO.Biological.Process	GO:1903205	regulation.of.hydrogen.peroxide-induced.cell.death	441	7.137113e-32	9.219009e-28	2.090478e-30	2.932432e+0	HDAC6,LRRK2,PDE8A,RACK1,RIPK1,STK26	MammalianAncestor	27.0353
GO.Biological.Process	GO:0006702	androgen.biosynthetic.process	442	7.367425e-32	9.516503e-28	2.153055e-30	4.712886e+0	HSD3B1,HSD3B2,SRD5A2	MammalianAncestor	27.0215
GO.Biological.Process	GO:0051349	positive.regulation.of.lyase.activity	443	7.990267e-32	1.032103e-27	2.329803e-30	2.085168e+0	ADCY1,ADORA2B,CRHR1,ENSG00000214732,FTMT,GUCA1B,GUCA2A,GUCA2B,VIPR2	MammalianAncestor	26.9863
GO.Biological.Process	GO:1900041	negative.regulation.of.interleukin-2.secretion	444	8.845111e-32	1.142523e-27	2.573250e-30	6.999558e+0	TRIM27	MammalianAncestor	26.9421
GO.Biological.Process	GO:0002251	organ.or.tissue.specific.immune.response	445	9.072903e-32	1.171947e-27	2.633588e-30	4.220505e+0	CAMP,DEFA1,DEFA3,DEFB1,HIST1H2BJ,HIST1H2BK,LTF,RNASE3	MammalianAncestor	26.9311
GO.Biological.Process	GO:0033235	positive.regulation.of.protein.sumoylation	446	1.231298e-31	1.590468e-27	3.566071e-30	4.279946e+0	HDAC4,PIAS3	MammalianAncestor	26.7985
GO.Biological.Process	GO:0051339	regulation.of.lyase.activity	447	1.314069e-31	1.697383e-27	3.797277e-30	1.845157e+0	ADCY1,ADORA2B,CRHR1,ENSG00000214732,FPR2,FTMT,GABBR1,GABBR2,GUCA1B,GUCA2A,GUCA2B,OR13F1,VIPR2	MammalianAncestor	26.7702
GO.Biological.Process	GO:0032673	regulation.of.interleukin-4.production	448	1.399693e-31	1.807983e-27	4.035677e-30	2.829026e+0	CD86,IL20RB,NLRP3,SCGB1A1,TNFSF4	MammalianAncestor	26.7428
GO.Biological.Process	GO:0051187	cofactor.catabolic.process	449	1.482144e-31	1.914485e-27	4.263887e-30	3.988483e+0	ALDH1L1,AMBP,BLVRA,CYP4F11,CYP4F2,MTHFS	MammalianAncestor	26.7179
GO.Biological.Process	GO:0006711	estrogen.catabolic.process	450	1.590500e-31	2.054449e-27	4.565442e-30	1.391336e+1	SULT1E1,UGT2B4	MammalianAncestor	26.6873
GO.Biological.Process	GO:1902110	positive.regulation.of.mitochondrial.membrane.permeability.involved.in.apoptotic.process	451	1.773054e-31	2.290254e-27	5.078168e-30	3.917852e+0	PMAIP1	MammalianAncestor	26.6401
GO.Biological.Process	GO:1902235	regulation.of.endoplasmic.reticulum.stress-induced.intrinsic.apoptotic.signaling.pathway	452	2.565118e-31	3.313363e-27	7.330449e-30	3.070929e+0	HSPA1A,LRRK2,MAGEA3,NCK1,PMAIP1	MammalianAncestor	26.4797
GO.Biological.Process	GO:0050913	sensory.perception.of.bitter.taste	453	2.617890e-31	3.381529e-27	7.464743e-30	3.812536e+0	AZGP1,CST1,CST2,CST4,RTP3,RTP5,TAS2R3,TAS2R38,TAS2R4,TAS2R5	MammalianAncestor	26.4709
GO.Biological.Process	GO:0006059	hexitol.metabolic.process	454	3.330357e-31	4.301822e-27	9.475379e-30	1.429394e+1	AKR1B1,SORD	MammalianAncestor	26.3663
GO.Biological.Process	GO:0010951	negative.regulation.of.endopeptidase.activity	455	3.484930e-31	4.501484e-27	9.893372e-30	1.682209e+0	AMBP,ANXA8,BEX3,CARD8,COL28A1,CRIM1,CSN2,CST1,CST11,CST2,CST3,CST4,CST5,CST7,CST8,CST9,CST9L,CSTL1,ENSG00000267748,FURIN,IFI16,LTF,MAGEA3,NGF,OPRPN,PAK2,PAX2,PCSK1N,PLAUR,SERPINB6,SERPINB8,SERPINB9,SERPIND1,SERPINE1,SPINK2,SPINK8,SPINT2,USP14,WNT9A,YWHAE	MammalianAncestor	26.3466
GO.Biological.Process	GO:0002859	negative.regulation.of.natural.killer.cell.mediated.cytotoxicity.directed.against.tumor.cell.target	456	3.749772e-31	4.843580e-27	1.062189e-29	2.133253e+1	CEACAM1	MammalianAncestor	26.3148
GO.Biological.Process	GO:0043029	T.cell.homeostasis	457	3.916207e-31	5.058565e-27	1.106907e-29	3.289058e+0	IL2RA,PMAIP1,SLC46A2	MammalianAncestor	26.296
GO.Biological.Process	GO:0006024	glycosaminoglycan.biosynthetic.process	458	4.443771e-31	5.740019e-27	1.253279e-29	1.711091e+0	B3GAT1,B4GAT1,CHST13,CHST7,CHSY3,CSGALNACT1,CSGALNACT2,CSPG4,GPC1,HAS1,HS3ST2,HS3ST3A1,HS6ST1,PXYLP1,XYLT2	MammalianAncestor	26.2411
GO.Biological.Process	GO:0040016	embryonic.cleavage	459	4.615303e-31	5.961587e-27	1.298821e-29	4.855922e+0	PIK3CB,TPRA1	MammalianAncestor	26.2246
GO.Biological.Process	GO:0050858	negative.regulation.of.antigen.receptor-mediated.signaling.pathway	460	4.999912e-31	6.458386e-27	1.403997e-29	3.371399e+0	CEACAM1,DUSP22,FCRL3,PRNP,PVRIG	MammalianAncestor	26.1899
GO.Biological.Process	GO:0050830	defense.response.to.Gram-positive.bacterium	461	5.038923e-31	6.508777e-27	1.411882e-29	2.347202e+0	ACP5,CAMP,CRP,CTSG,DEFA1,DEFA3,DEFA4,DEFA5,DEFB1,DEFB103A,DEFB103B,DEFB128,DEFB4A,DEFB4B,HIST1H2BJ,HIST1H2BK,LBP,LTA,NLRP3,REG3G,RNASE3,RNASE6,RNASE7,RNASE8,SPACA4,SPACA5,SPACA5B	MammalianAncestor	26.1865
GO.Biological.Process	GO:0006023	aminoglycan.biosynthetic.process	462	5.293323e-31	6.837385e-27	1.479954e-29	1.709781e+0	B3GAT1,B4GAT1,CHST13,CHST7,CHSY3,CSGALNACT1,CSGALNACT2,CSPG4,GPC1,HAS1,HS3ST2,HS3ST3A1,HS6ST1,PXYLP1,XYLT2	MammalianAncestor	26.1651
GO.Biological.Process	GO:0048525	negative.regulation.of.viral.process	463	5.505381e-31	7.111301e-27	1.535918e-29	2.317261e+0	APCS,IFI16,LTF,MAVS,MID2,OAS1,OAS3,REST,TRIM10,TRIM11,TRIM14,TRIM15,TRIM26,TRIM27,TRIM31	MammalianAncestor	26.1481
GO.Biological.Process	GO:0001978	regulation.of.systemic.arterial.blood.pressure.by.carotid.sinus.baroreceptor.feedback	464	5.635347e-31	7.279178e-27	1.568788e-29	6.164869e+0	ADRA1A,CHRNA7	MammalianAncestor	26.1379
GO.Biological.Process	GO:0043517	positive.regulation.of.DNA.damage.response,.signal.transduction.by.p53.class.mediator	465	5.977759e-31	7.721471e-27	1.660531e-29	3.669952e+0	PMAIP1,PYHIN1,RPL26	MammalianAncestor	26.1123
GO.Biological.Process	GO:0044272	sulfur.compound.biosynthetic.process	466	6.007798e-31	7.760273e-27	1.665295e-29	1.622382e+0	B3GAT1,B4GAT1,CBSL,CHST13,CHST7,CHSY3,CSGALNACT1,CSGALNACT2,CSPG4,GGT1,GGT2,GGT6,GGTLC1,GGTLC2,HS6ST1,MAT1A,PPT2,PXYLP1,TPK1,VANGL2,XYLT2	MammalianAncestor	26.1101
GO.Biological.Process	GO:0045628	regulation.of.T-helper.2.cell.differentiation	467	1.028623e-30	1.328672e-26	2.845123e-29	3.777443e+0	CD86,IL4R,NLRP3,TNFSF4	MammalianAncestor	25.8766
GO.Biological.Process	GO:0015851	nucleobase.transport	468	2.167477e-30	2.799730e-26	5.982329e-29	5.320812e+0	SLC28A1,VDAC3	MammalianAncestor	25.5529
GO.Biological.Process	GO:1905475	regulation.of.protein.localization.to.membrane	469	2.776514e-30	3.586423e-26	7.646958e-29	1.689110e+0	DLG1,EGFR,EPHB2,FIS1,GZMB,PDZK1,PKDCC,PMAIP1,PRNP,RACK1,RAMP3,RANGRF,SORBS1,TCAF1,TCAF2,USP17L2,VAMP7,YWHAE	MammalianAncestor	25.4453
GO.Biological.Process	GO:0002263	cell.activation.involved.in.immune.response	470	3.210788e-30	4.147375e-26	8.824202e-29	1.411731e+0	ACTR1B,ALOX5,ARMC8,ASAH1,ATP8B4,B2M,CAMP,CD177,CD244,CD86,CEACAM1,CEACAM3,CEACAM6,CEACAM8,CHRNB4,CST3,CTSB,CTSG,CTSH,CX3CR1,DBNL,DEFA1,DEFA4,FCGR2A,FCGR2B,FCGR3B,FPR1,FPR2,GLA,HGSNAT,HSPA1A,HSPA1B,HSPA6,IMPDH1,IQGAP1,ITGAL,ITGB2,KCMF1,LAT,LBP,LILRB2,LILRB3,LTF,LY9,MGAM,MNDA,MRGPRX2,NEU1,ORM1,ORM2,OSCAR,PFKL,PLAUR,PNP,PPIA,PRDX6,QPCT,RAB7A,RAB9B,RELB,RNASE2,RNASE3,RNF8,ROCK1,SERPINB6,SIGLEC14,SIGLEC5,SIGLEC9,SLAMF1,SLAMF6,SLC27A2,SNAP29,STK10,TARM1,TMEM179B,TNFSF18,TSPAN14,TYROBP,VAMP7	MammalianAncestor	25.3822
GO.Biological.Process	GO:0002232	leukocyte.chemotaxis.involved.in.inflammatory.response	471	3.933350e-30	5.080708e-26	1.078707e-28	1.400426e+1	LBP,SLAMF1	MammalianAncestor	25.2941
GO.Biological.Process	GO:0045213	neurotransmitter.receptor.metabolic.process	472	4.069898e-30	5.257087e-26	1.113790e-28	5.266942e+0	FNTA,NRG1	MammalianAncestor	25.2793
GO.Biological.Process	GO:0060456	positive.regulation.of.digestive.system.process	473	4.288581e-30	5.539560e-26	1.171154e-28	5.121380e+0	TACR1	MammalianAncestor	25.2565
GO.Biological.Process	GO:0006925	inflammatory.cell.apoptotic.process	474	5.061127e-30	6.537458e-26	1.379210e-28	5.176896e+0	FASLG	MammalianAncestor	25.1846
GO.Biological.Process	GO:0002399	MHC.class.II.protein.complex.assembly	475	5.627232e-30	7.268696e-26	1.530252e-28	1.622469e+1	HLA-DRA,HLA-DRB1	MammalianAncestor	25.1385
GO.Biological.Process	GO:0014854	response.to.inactivity	476	6.002691e-30	7.753676e-26	1.628924e-28	3.963005e+0	ACTN3,HDAC4	MammalianAncestor	25.1105
GO.Biological.Process	GO:0015074	DNA.integration	477	6.090928e-30	7.867652e-26	1.649403e-28	5.815029e+0	KRBA2,ZBED9	MammalianAncestor	25.1042
GO.Biological.Process	GO:0002444	myeloid.leukocyte.mediated.immunity	478	6.131902e-30	7.920578e-26	1.657025e-28	1.470248e+0	ACTR1B,ALOX5,ARMC8,ASAH1,ATP8B4,B2M,CAMP,CD177,CEACAM1,CEACAM3,CEACAM6,CEACAM8,CHRNB4,CST3,CTSB,CTSG,CTSH,DBNL,DEFA1,DEFA4,FCGR2A,FCGR3B,FPR1,FPR2,GLA,HGSNAT,HSPA1A,HSPA1B,HSPA6,IMPDH1,IQGAP1,ITGAL,ITGB2,KCMF1,LAT,LILRB2,LILRB3,LTF,MGAM,MNDA,MRGPRX2,NEU1,ORM1,ORM2,OSCAR,PFKL,PLAUR,PNP,PPIA,PRDX6,QPCT,RAB7A,RAB9B,RNASE2,RNASE3,ROCK1,SERPINB6,SERPINB9,SIGLEC14,SIGLEC5,SIGLEC9,SLC27A2,SNAP29,STK10,TARM1,TMEM179B,TSPAN14,TYROBP,VAMP7	MammalianAncestor	25.1012
GO.Biological.Process	GO:0070472	regulation.of.uterine.smooth.muscle.contraction	479	6.215834e-30	8.028993e-26	1.676199e-28	4.213683e+0	ADRA2B,TACR1	MammalianAncestor	25.0953
GO.Biological.Process	GO:0043152	induction.of.bacterial.agglutination	480	6.778301e-30	8.755531e-26	1.824069e-28	7.879899e+0	RNASE3,SFTPD	MammalianAncestor	25.0577
GO.Biological.Process	GO:0050433	regulation.of.catecholamine.secretion	481	7.048909e-30	9.105076e-26	1.892947e-28	2.055773e+0	ADRA2B,CHRNA6,CHRNA7,CXCL12,OR13F1	MammalianAncestor	25.0407
GO.Biological.Process	GO:0007321	sperm.displacement	482	7.644822e-30	9.874817e-26	2.048717e-28	4.400745e+1	EDDM3A	MammalianAncestor	25.0055
GO.Biological.Process	GO:0002933	lipid.hydroxylation	483	7.945645e-30	1.026339e-25	2.124925e-28	1.065863e+1	CYP3A4,CYP3A5,CYP3A7,CYP3A7-CYP3A51P	MammalianAncestor	24.9887
GO.Biological.Process	GO:0050672	negative.regulation.of.lymphocyte.proliferation	484	8.351980e-30	1.078825e-25	2.228978e-28	2.106037e+0	BTN2A2,DLG1,FCGR2B,HLA-G,IL20RB,IL2RA,LILRB2,MNDA,PRNP,SCGB1A1,SFTPD,SPN,TNFRSF13B	MammalianAncestor	24.967
GO.Biological.Process	GO:0050912	detection.of.chemical.stimulus.involved.in.sensory.perception.of.taste	485	8.393162e-30	1.084145e-25	2.235350e-28	3.655570e+0	AZGP1,CST1,CST2,CST4,RTP3,RTP5,TAS2R3,TAS2R38,TAS2R4,TAS2R5	MammalianAncestor	24.9649
GO.Biological.Process	GO:0045760	positive.regulation.of.action.potential	486	9.559372e-30	1.234784e-25	2.540708e-28	3.551343e+0	ADRA1A,NOS1AP,TACR1	MammalianAncestor	24.9084
GO.Biological.Process	GO:0042129	regulation.of.T.cell.proliferation	487	1.099907e-29	1.420750e-25	2.917351e-28	1.733764e+0	BTN2A2,CD1D,CD244,CD86,DLG1,HLA-G,ICOSLG,IL20RB,IL2RA,LILRB2,NCK1,PNP,PRNP,SCGB1A1,SFTPD,SLAMF1,SPN,TNFSF18,TNFSF4,ZAP70	MammalianAncestor	24.8475
GO.Biological.Process	GO:0032660	regulation.of.interleukin-17.production	488	1.114779e-29	1.439960e-25	2.950738e-28	2.933326e+0	LY9,PRNP,SLAMF6,TNFSF4	MammalianAncestor	24.8416
GO.Biological.Process	GO:0002710	negative.regulation.of.T.cell.mediated.immunity	489	1.164811e-29	1.504586e-25	3.076864e-28	3.640953e+0	CEACAM1,DUSP22,FCGR2B,IL20RB,SLAMF1,SPN	MammalianAncestor	24.8226
GO.Biological.Process	GO:0002396	MHC.protein.complex.assembly	490	1.171361e-29	1.513047e-25	3.087851e-28	1.586700e+1	HLA-DRA,HLA-DRB1	MammalianAncestor	24.8201
GO.Biological.Process	GO:0071346	cellular.response.to.interferon-gamma	491	1.314857e-29	1.698401e-25	3.459065e-28	2.018849e+0	B2M,CCL24,CCL25,CCL26,FCGR1A,FCGR1B,HLA-B,HLA-DQA1,HLA-DQA2,HLA-DQB2,HLA-DRA,HLA-DRB1,HLA-DRB5,HLA-F,HLA-G,IRF6,OAS1,OAS2,OAS3,TDGF1,TRIM26,TRIM31	MammalianAncestor	24.77
GO.Biological.Process	GO:0006684	sphingomyelin.metabolic.process	492	1.331867e-29	1.720373e-25	3.496692e-28	5.029968e+0	SGMS1,SMPD4	MammalianAncestor	24.7644
GO.Biological.Process	GO:0019852	L-ascorbic.acid.metabolic.process	493	2.713103e-29	3.504515e-25	7.108550e-28	5.665173e+0	RGN,SLC2A1	MammalianAncestor	24.4554
GO.Biological.Process	GO:0033590	response.to.cobalamin	494	2.969592e-29	3.835822e-25	7.764822e-28	8.499583e+0	EGFR	MammalianAncestor	24.4161
GO.Biological.Process	GO:0061098	positive.regulation.of.protein.tyrosine.kinase.activity	495	3.095674e-29	3.998682e-25	8.078146e-28	2.334726e+0	ADRA2B,ALKAL2,ERCC6,GHRL,PAK2,PRNP,TGFA	MammalianAncestor	24.3981
GO.Biological.Process	GO:0002767	immune.response-inhibiting.cell.surface.receptor.signaling.pathway	496	3.255060e-29	4.204561e-25	8.476938e-28	9.289301e+0	HLA-G,LILRB2	MammalianAncestor	24.3763
GO.Biological.Process	GO:0042058	regulation.of.epidermal.growth.factor.receptor.signaling.pathway	497	5.656334e-29	7.306287e-25	1.470078e-27	1.912715e+0	ADRA2B,CEACAM1,EGFR,EPN1,FASLG,HIP1,PLAUR,PTPN3,RAB7A,RNF115,TGFA	MammalianAncestor	24.1363
GO.Biological.Process	GO:0048521	negative.regulation.of.behavior	498	7.011204e-29	9.056372e-25	1.818549e-27	3.210358e+0	GHRL,MC4R,TRH	MammalianAncestor	24.043
GO.Biological.Process	GO:0006195	purine.nucleotide.catabolic.process	499	7.645645e-29	9.875880e-25	1.979134e-27	2.210924e+0	HINT1,NUDT10,NUDT11,PDE8A,PNP,XDH	MammalianAncestor	24.0054
GO.Biological.Process	GO:0048293	regulation.of.isotype.switching.to.IgE.isotypes	500	9.680888e-29	1.250480e-24	2.500961e-27	6.512416e+0	TNFSF4	MammalianAncestor	23.9029
#.GO.Biological.Process	12917	1	1000	MammalianAncestor	inf